{"id":13540,"date":"2021-01-31T22:14:42","date_gmt":"2021-02-01T03:14:42","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-colite-ulcerativa-anderson-2011\/"},"modified":"2021-02-20T20:42:49","modified_gmt":"2021-02-21T01:42:49","slug":"genetica-de-colite-ulcerativa-anderson-2011","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-colite-ulcerativa-anderson-2011\/","title":{"rendered":"Colite Ulcerativa (Anderson, 2011)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> A meta-an\u00e1lise identifica 29 loci de risco de colite ulcerativa adicional, aumentando o n\u00famero de associa\u00e7\u00f5es confirmadas para 47<\/a><\/p>\n\n

RESUMO:<\/strong> Variantes gen\u00e9ticas ligadas \u00e0 inflama\u00e7\u00e3o e morte celular programada podem afetar o risco de colite ulcerosa.<\/p>\n\n

DESCRI\u00c7\u00c3O:<\/strong> A colite ulcerativa (CU) \u00e9 uma doen\u00e7a inflamat\u00f3ria intestinal que ocorre quando feridas se desenvolvem no c\u00f3lon devido a uma inflama\u00e7\u00e3o cont\u00ednua. Sintomas como diarreia, dor abdominal e fadiga geralmente se desenvolvem com o tempo. A UC tamb\u00e9m \u00e9 conhecida por ser heredit\u00e1ria, mas os fatores gen\u00e9ticos subjacentes a isso n\u00e3o s\u00e3o bem compreendidos. Este estudo examinou mais de 40.000 indiv\u00edduos de ascend\u00eancia europeia e descobriu 29 novas variantes gen\u00e9ticas associadas \u00e0 UC. Muitas dessas variantes estavam anteriormente associadas \u00e0 morte celular programada e ao sistema imunol\u00f3gico, em particular a inflama\u00e7\u00e3o. Estima-se que as novas variantes explicam 16% da herdabilidade para UC, com todas as variantes significativas explicando 28% de sua herdabilidade.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Para reduzir os sintomas da colite ulcerosa, beba bastante \u00e1gua, limite os latic\u00ednios e fa\u00e7a exerc\u00edcios regularmente. [ FONTE<\/a> ]<\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> .<\/p>\n\n

\"Relatório<\/a><\/figure>\n\n

VARIANTES ASSOCIADOS \u00c0 UC:<\/strong> rs9268853, rs6426833, rs11209026, rs10758669, rs2836878, rs6871626, rs6584283, rs6017342, rs1801274, rs10781499, rs16940202, rs9822268, rs3024505, rs6920220, rs17085007, rs7134599, rs4510766, rs2155219, rs798502, rs7608910, rs678170, rs7524102, rs7554511, rs1297265, rs2310173, rs941823, rs4246905, rs267939, rs2872507, rs2838519, rs4676406, rs11676348, rs907611, rs2297441, rs943072, rs12261843, rs254560, rs6451493 *, rs734999, rs35675666, rs6911490, rs4728142, rs11739663, rs6499188, rs3194051<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong> Colite Ulcerativa – Sintomas e Causas<\/a>Morte celular programada (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 30 de agosto de 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: A meta-an\u00e1lise identifica 29 loci de risco de colite ulcerativa adicional, aumentando o n\u00famero de associa\u00e7\u00f5es confirmadas para 47 RESUMO: Variantes gen\u00e9ticas ligadas \u00e0 inflama\u00e7\u00e3o e morte celular programada podem afetar o risco de colite ulcerosa. DESCRI\u00c7\u00c3O: …<\/p>\n

Colite Ulcerativa (Anderson, 2011)<\/span> Leia mais 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