{"id":13566,"date":"2021-01-31T22:14:55","date_gmt":"2021-02-01T03:14:55","guid":{"rendered":"https:\/\/nebula.org\/blog\/suscetibilidade-sars-cov-2\/"},"modified":"2021-02-20T20:56:20","modified_gmt":"2021-02-21T01:56:20","slug":"suscetibilidade-sars-cov-2","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/suscetibilidade-sars-cov-2\/","title":{"rendered":"COVID-19 e o surto de SARS de 2003"},"content":{"rendered":"\n

Introdu\u00e7\u00e3o ao SARS<\/strong><\/h2>\n\n

A s\u00edndrome respirat\u00f3ria aguda grave coronav\u00edrus (SARS-CoV) surgiu em 2003<\/a> na China. Seguiu-se uma epidemia que se espalhou por 26 pa\u00edses e infectou mais de 8.000 pessoas antes de o v\u00edrus ser contido. Os sintomas t\u00edpicos da SARS s\u00e3o semelhantes aos da gripe, incluindo febre, dor de cabe\u00e7a e sensa\u00e7\u00e3o geral de desconforto. Casos graves da doen\u00e7a eram comuns, resultando em uma taxa de mortalidade de quase 10%. Devido \u00e0 gravidade dos sintomas, foi poss\u00edvel<\/a> para identificar aqueles infectados com SARS-CoV e isol\u00e1-los. Medidas de sa\u00fade p\u00fablica como distanciamento social<\/a> tiveram sucesso em conter o surto. <\/p>\n\n

SARS e a pandemia COVID-19<\/strong><\/h2>\n\n

A situa\u00e7\u00e3o \u00e9 diferente com hoje Pandemia do covid-19<\/a> . Este novo coronav\u00edrus (SARS-CoV-2) pode infectar pessoas que permanecem em grande parte assintom\u00e1tico<\/a> . Isso torna muito mais dif\u00edcil identificar e conter os infectados que continuam a espalhar a doen\u00e7a. Embora a taxa de mortalidade de COVID-19 seja estimado<\/a> sendo 5 a 10 vezes menor do que o SARS, o n\u00famero total de mortes j\u00e1 ultrapassou o surto de SARS devido \u00e0 falha em conter a pandemia. <\/p>\n\n

No entanto, SARS-CoV e SARS-CoV-2 tamb\u00e9m compartilham muitos semelhan\u00e7as<\/a> . Ambos os v\u00edrus se originaram em morcegos e compartilham 80% de seu c\u00f3digo gen\u00e9tico. Al\u00e9m disso, ambos os v\u00edrus infectam o trato respirat\u00f3rio usando o mesmo mecanismo<\/a> , e eles causam sintomas semelhantes. <\/p>\n\n

Enquanto nosso entendimento do COVID-19<\/a> ainda est\u00e1 faltando, muitas pesquisas sobre SARS foram produzidas nos anos ap\u00f3s 2003. Os pesquisadores identificaram variantes gen\u00e9ticas que est\u00e3o associadas \u00e0 suscetibilidade \u00e0 infec\u00e7\u00e3o pelo SARS-CoV. Permanece uma quest\u00e3o em aberto se as mesmas variantes gen\u00e9ticas tamb\u00e9m est\u00e3o associadas \u00e0 suscetibilidade \u00e0 infec\u00e7\u00e3o por SARS-CoV-2, dadas as semelhan\u00e7as entre os dois coronav\u00edrus. <\/p>\n\n

Para informar nossos usu\u00e1rios sobre pesquisas anteriores sobre coronav\u00edrus, adicionamos 3 estudos sobre infec\u00e7\u00e3o por coronav\u00edrus por SARS ao Nebula Research Library<\/a> . Esses estudos nos d\u00e3o alguma compreens\u00e3o das liga\u00e7\u00f5es entre a gen\u00e9tica humana e a infec\u00e7\u00e3o por coronav\u00edrus.<\/p>\n\n

\"Casos
O n\u00famero de casos COVID-19 ultrapassou o n\u00famero de casos de SARS no in\u00edcio de fevereiro de 2020. Fonte: statista \/ CDC<\/a> .<\/figcaption><\/figure>\n\n

<\/p>\n\n

Entradas da biblioteca de nebulosa em SARS<\/strong><\/h2>\n\n

Infec\u00e7\u00e3o por coronav\u00edrus SARS (Hamano, 2005)<\/h4>\n\n

Este estudo explorou dados gen\u00e9ticos de indiv\u00edduos vietnamitas e identificou uma variante gen\u00e9tica na OAS-1<\/em> gene que est\u00e1 associado \u00e0 suscetibilidade \u00e0 infec\u00e7\u00e3o pelo coronav\u00edrus SARS.<\/p>\n\n

Infec\u00e7\u00e3o por coronav\u00edrus SARS (Ching, 2010)<\/h4>\n\n

Este estudo usou dados gen\u00e9ticos de indiv\u00edduos chineses para demonstrar que uma variante gen\u00e9tica est\u00e1 ligada a uma diminui\u00e7\u00e3o da suscetibilidade \u00e0 infec\u00e7\u00e3o por coronav\u00edrus SARS. Esta variante \u00e9 encontrada perto de MxA<\/em> gene, que normalmente desempenha um papel na inibi\u00e7\u00e3o da replica\u00e7\u00e3o dos coronav\u00edrus SARS.<\/p>\n\n

Infec\u00e7\u00e3o por coronav\u00edrus SARS (Tu, 2015)<\/h4>\n\n

Este estudo examinou os dados gen\u00e9ticos de pacientes chineses com SARS para identificar variantes em 2 genes que levam a um risco aumentado de infec\u00e7\u00e3o. Uma variante est\u00e1 no CCL2<\/em> gene, que desempenha um papel na atra\u00e7\u00e3o de macr\u00f3fagos para um local de infec\u00e7\u00e3o. A outra variante est\u00e1 no MBL<\/em> gene, que ajuda o sistema imunol\u00f3gico a reconhecer padr\u00f5es moleculares comumente encontrados na superf\u00edcie de muitos v\u00edrus e bact\u00e9rias.<\/p>\n\n

Nova pesquisa COVID-19<\/strong><\/h2>\n\n

Em breve, estudos sobre a suscetibilidade \u00e0 SARS-CoV-2 e o papel da gen\u00e9tica ser\u00e3o publicados. Aqui na Nebula, estamos monitorando a pesquisa sobre o COVID-19 e forneceremos aos nossos usu\u00e1rios atualiza\u00e7\u00f5es oportunas. Voc\u00ea pode ficar atualizado com as \u00faltimas descobertas das pesquisas adquirindo nosso sequenciamento do genoma completo<\/a> ou enviando o seu Dados 23andMe ou AncestryDNA<\/a> .<\/p>\n\n

Para atualiza\u00e7\u00f5es sobre a gen\u00e9tica de COVID-19, visite: https:\/\/nebula.org\/blog\/category\/science\/<\/a><\/p>\n\n

Voc\u00ea tamb\u00e9m pode aprender mais sobre os testes de coronav\u00edrus nesta postagem do blog.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Introdu\u00e7\u00e3o ao SARS A s\u00edndrome respirat\u00f3ria aguda grave coronav\u00edrus (SARS-CoV) surgiu em 2003 na China. Seguiu-se uma epidemia que se espalhou por 26 pa\u00edses e infectou mais de 8.000 pessoas antes de o v\u00edrus ser contido. Os sintomas t\u00edpicos da …<\/p>\n

COVID-19 e o surto de SARS de 2003<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":11,"featured_media":13569,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[5002],"tags":[],"class_list":["post-13566","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-pt-br"],"yoast_head":"\nSuscetibilidade 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