{"id":1014,"date":"2020-04-09T21:34:00","date_gmt":"2020-04-10T01:34:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1014"},"modified":"2021-01-27T01:56:08","modified_gmt":"2021-01-27T06:56:08","slug":"genetics-of-breast-cancer-fachal-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-breast-cancer-fachal-2020\/","title":{"rendered":"Breast Cancer (Fachal, 2020)"},"content":{"rendered":"\n<p><strong>STUDY TITLE: <\/strong> <a href=\"https:\/\/www.nature.com\/articles\/s41588-019-0537-1\">Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.<\/a><\/p>\n\n\n\n<p><strong>SUMMARY:<\/strong> Identification of 206 genetic variants associated with a risk of developing breast cancer.<\/p>\n\n\n\n<p><strong>OVERVIEW:<\/strong> Breast cancer is currently the second most common cancer among women (behind skin cancer), affecting nearly 1 in 8 during their lifetime. Nearly 10% of all cases of breast cancer are thought to be hereditary. This study examined genetic data from over 215,000 women of European ancestry to identify genetic regions associated with an increased risk of developing breast cancer. The analysis discovered 206 variants across 129 genomic regions strongly associated with breast cancer risk. Collectively these genetic variants explain over 20% of the hereditary cancer risk. Many of the discovered variants are near genes that are related to the immune system, which indicates its importance in protecting us against cancer.<br><\/p>\n\n\n\n<p><strong>DID YOU KNOW?<\/strong>  Research suggests that long-term exposure to some plastics may increase the risk of developing breast cancer. In particular, plastics that contain bisphenol A (BPA). It is believed to interfere with the hormone system by mimicking the female sex hormone, estrogen. Look for the \u201cBPA free\u201d label on plastics and consider switching to a reusable water bottle made of metal or glass. [<a href=\"https:\/\/www.breastcancer.org\/risk\/factors\/plastic\">SOURCE<\/a>]<\/p>\n\n\n\n<p><strong>SAMPLE RESULTS:<\/strong>  Learn more about the\u00a0<a href=\"https:\/\/nebula.org\/blog\/nebula-library-unlocking-genetic-research\/\">Nebula Research Library<\/a>. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><img decoding=\"async\" width=\"1024\" height=\"375\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-1024x375.png\" alt=\"breast cancer sample results\" class=\"wp-image-1128\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-1024x375.png 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-300x110.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-768x281.png 768w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-1536x562.png 1536w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3.png 924w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>ANALYZED VARIANTS: <\/strong>rs4784227, rs10941679, rs4442975, rs11249433, rs186430430, rs659713, rs62355902, rs7297051, rs10995201, rs1353783, rs10069690, rs138522813, rs35378451, rs2403907, rs754416, rs17356907, rs244321, rs1352944, rs60037937, rs620315, rs2307561, rs45631563, rs199660865, rs55872725, rs4951401, rs78540526, rs66987842, rs8105994, rs7098100, rs851984, rs31864, rs34133739, rs12173562, rs7664956, rs5838651, rs657244, rs7465364, rs9938021, rs657686, rs12881240, rs9421409, rs56344893, rs2736107, rs10816625, rs11373454, rs2478777, rs6787391, rs2992756, rs35263707, rs13294895, rs4849879, rs10762851, rs4286946, rs5995543, rs7813150, rs2003526, rs11571833, rs9925952, rs13153426, rs143384623, rs71403627, rs62334412, rs4950774, rs2016394, rs984113, rs3769821, rs56387622, rs35422, rs78955132, rs405447, rs12706954, rs2059891, rs12250948, rs7625643, rs12048493, rs1964292, rs28539243, rs527616, rs56722914, rs9952980, rs12594752, rs7796917, rs1057941, rs11341843, rs190443933, rs72755295, rs548082010, rs1882155, rs13294352, rs848088, rs7017073, rs12039667, rs4076654, rs35409891, rs138026227, rs35961416, rs148509105, rs17879961, rs4871411, rs74174203, rs17625845, rs419018, rs150957507, rs6854739, rs571173399, rs17617028, rs745382, rs78105464, rs7763102, rs1879854, rs112497245, rs10034903, rs200835870, rs71973726, rs61862474, rs78440108, rs67397200, rs6973318, rs62485509, rs58847541, rs506186, rs10096351, rs117618124, rs2328531, rs5997389, rs6569648, rs7541276, rs12422552, rs2822999, rs11448973, rs11102701, rs373575834, rs34810249, rs10641009, rs671888, rs1600346, rs10184522, rs11117754, rs7785971, rs537267133, rs199661266, rs12652713, rs2587505, rs13015648, rs2384061, rs12970390, rs2012709, rs7589172, rs1469713, rs3819405, rs35383942, rs7971, rs7081544, rs11382527, rs2981578, rs79309050, rs13020413, rs4800749, rs17303163, rs184486140, rs9619765, rs8137282, rs11583393, rs13267382, rs4066743, rs7529522, rs6500580, rs62070949, rs555060306, rs150804576, rs17513613, rs59867004, rs201000337, rs8063564, rs13066793, rs200366104, rs78269692, rs16991615, rs11704298, rs368848598, rs11067765, rs3846498, rs17432750, rs7730210, rs9573140, rs180952292, rs149934734, rs2363956, rs35054928, rs79388591, rs9918437, rs144101714, rs7899765, rs66496128, rs17467658, rs4587, rs184070480, rs10472097, rs72764096, rs7740686, rs7763637<\/p>\n\n\n\n<p><strong>ADDITIONAL RESOURCES:<\/strong><br><a href=\"https:\/\/www.cancer.org\/cancer\/breast-cancer\/about\/what-is-breast-cancer.html\">Breast cancer<\/a><\/p>\n\n\n\n<p><strong>WEEKLY UPDATE:<\/strong> January 17, 2020<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STUDY TITLE: Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. SUMMARY: Identification of 206 genetic variants associated with a risk of developing breast cancer. OVERVIEW: Breast cancer is currently the second most common cancer among women &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/genetics-of-breast-cancer-fachal-2020\/\"> <span class=\"screen-reader-text\">Breast Cancer (Fachal, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1054,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1014","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"<!-- 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