{"id":1077,"date":"2020-04-09T22:07:00","date_gmt":"2020-04-10T02:07:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1077"},"modified":"2021-04-16T18:54:35","modified_gmt":"2021-04-16T22:54:35","slug":"genetics-of-kawasaki-disease-onouchi-2012","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/","title":{"rendered":"Kawasaki Disease (Onouchi, 2012)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>A genome-wide association study identifies three new risk loci for Kawasaki disease <\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 3 genetic variants associated with Kawasaki disease, which causes inflammation and swelling of blood vessels.<\/p>\n\n\n\n

OVERVIEW: \u00a0<\/strong>Kawasaki disease is characterized by sudden inflammation and swelling of blood vessels throughout the body that typically persists for several days. It primarily affects children under the age of 5, but cases of the disease in adults have also been described. A typical symptom of the disease is redness that affects various parts of the body including eyes, tongue, and skin.\u00a0Kawasaki disease is common in parts of East Asia, particularly Japan. By examining almost 4,000 children of Japanese ancestry, this genome-wide association study identified 3 genetic variants associated with the disease. Two of these genetic variants are within genomic regions previously associated with autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus<\/a>.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> For children in the United States, Kawasaki disease is the leading cause of acquired heart disease. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"kawasaki<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

KAWASAKI DISEASE-ASSOCIATED VARIANTS:<\/strong> rs2254546, rs2857151, rs4813003<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
What is Kawasaki disease?<\/a> (Video)
Kawasaki Disease <\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> January 23, 2020<\/p>\n\n\n\n


<\/p>\n\n\n\n


<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: A genome-wide association study identifies three new risk loci for Kawasaki disease SUMMARY: Identification of 3 genetic variants associated with Kawasaki disease, which causes inflammation and swelling of blood vessels. OVERVIEW: \u00a0Kawasaki disease is characterized by sudden inflammation …<\/p>\n

Kawasaki Disease (Onouchi, 2012)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1078,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1077","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe genetics of Kawasaki disease (Onouchi, 2012)<\/title>\n<meta name=\"description\" content=\"Upload your DNA data, explore genetic variants linked to Kawasaki disease (Onouchi, 2012), and discover your polygenic score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The genetics of Kawasaki disease (Onouchi, 2012)\" \/>\n<meta property=\"og:description\" content=\"Upload your DNA data, explore genetic variants linked to Kawasaki disease (Onouchi, 2012), and discover your polygenic score.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/\" \/>\n<meta property=\"og:site_name\" content=\"Nebula Genomics Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/nebulagenomics\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-10T02:07:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-16T22:54:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/kelly-sikkema-JRVxgAkzIsM-unsplash-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"924\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Garrett Dunlap, B.S.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:site\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Garrett Dunlap, B.S.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/\"},\"author\":{\"name\":\"Garrett Dunlap, B.S.\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\"},\"headline\":\"Kawasaki Disease (Onouchi, 2012)\",\"datePublished\":\"2020-04-10T02:07:00+00:00\",\"dateModified\":\"2021-04-16T22:54:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/\"},\"wordCount\":195,\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"articleSection\":[\"Reports\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/\",\"url\":\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/\",\"name\":\"The genetics of Kawasaki disease (Onouchi, 2012)\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/#website\"},\"datePublished\":\"2020-04-10T02:07:00+00:00\",\"dateModified\":\"2021-04-16T22:54:35+00:00\",\"description\":\"Upload your DNA data, explore genetic variants linked to Kawasaki disease (Onouchi, 2012), and discover your polygenic score.\",\"breadcrumb\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/nebula.org\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Kawasaki Disease (Onouchi, 2012)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/nebula.org\/blog\/#website\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"name\":\"Nebula Genomics Blog\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/nebula.org\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/nebula.org\/blog\/#organization\",\"name\":\"Nebula Genomics\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Nebula Genomics\"},\"image\":{\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/facebook.com\/nebulagenomics\",\"https:\/\/twitter.com\/nebulagenomics\",\"https:\/\/www.instagram.com\/nebulagenomics\/\",\"https:\/\/www.linkedin.com\/company\/nebula-genomics\/\",\"https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\",\"name\":\"Garrett Dunlap, B.S.\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"caption\":\"Garrett Dunlap, B.S.\"},\"description\":\"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.\",\"sameAs\":[\"https:\/\/nebula.org\/whole-genome-sequencing\/\"],\"url\":\"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The genetics of Kawasaki disease (Onouchi, 2012)","description":"Upload your DNA data, explore genetic variants linked to Kawasaki disease (Onouchi, 2012), and discover your polygenic score.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/","og_locale":"en_US","og_type":"article","og_title":"The genetics of Kawasaki disease (Onouchi, 2012)","og_description":"Upload your DNA data, explore genetic variants linked to Kawasaki disease (Onouchi, 2012), and discover your polygenic score.","og_url":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/","og_site_name":"Nebula Genomics Blog","article_publisher":"https:\/\/facebook.com\/nebulagenomics","article_published_time":"2020-04-10T02:07:00+00:00","article_modified_time":"2021-04-16T22:54:35+00:00","og_image":[{"width":924,"height":612,"url":"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/kelly-sikkema-JRVxgAkzIsM-unsplash-scaled.jpg","type":"image\/jpeg"}],"author":"Garrett Dunlap, B.S.","twitter_card":"summary_large_image","twitter_creator":"@nebulagenomics","twitter_site":"@nebulagenomics","twitter_misc":{"Written by":"Garrett Dunlap, B.S.","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/#article","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/"},"author":{"name":"Garrett Dunlap, B.S.","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e"},"headline":"Kawasaki Disease (Onouchi, 2012)","datePublished":"2020-04-10T02:07:00+00:00","dateModified":"2021-04-16T22:54:35+00:00","mainEntityOfPage":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/"},"wordCount":195,"publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"articleSection":["Reports"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/","url":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/","name":"The genetics of Kawasaki disease (Onouchi, 2012)","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/#website"},"datePublished":"2020-04-10T02:07:00+00:00","dateModified":"2021-04-16T22:54:35+00:00","description":"Upload your DNA data, explore genetic variants linked to Kawasaki disease (Onouchi, 2012), and discover your polygenic score.","breadcrumb":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/nebula.org\/blog\/genetics-of-kawasaki-disease-onouchi-2012\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/nebula.org\/blog\/"},{"@type":"ListItem","position":2,"name":"Kawasaki Disease (Onouchi, 2012)"}]},{"@type":"WebSite","@id":"https:\/\/nebula.org\/blog\/#website","url":"https:\/\/nebula.org\/blog\/","name":"Nebula Genomics Blog","description":"","publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nebula.org\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nebula.org\/blog\/#organization","name":"Nebula Genomics","url":"https:\/\/nebula.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Nebula Genomics"},"image":{"@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/facebook.com\/nebulagenomics","https:\/\/twitter.com\/nebulagenomics","https:\/\/www.instagram.com\/nebulagenomics\/","https:\/\/www.linkedin.com\/company\/nebula-genomics\/","https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics"]},{"@type":"Person","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e","name":"Garrett Dunlap, B.S.","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","caption":"Garrett Dunlap, B.S."},"description":"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/comments?post=1077"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1077\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media\/1078"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media?parent=1077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/categories?post=1077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/tags?post=1077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}