{"id":1089,"date":"2020-04-16T00:00:23","date_gmt":"2020-04-16T04:00:23","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1089"},"modified":"2021-01-27T01:56:05","modified_gmt":"2021-01-27T06:56:05","slug":"genetics-of-hearing-loss-wells-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/","title":{"rendered":"Hearing Loss (Wells, 2019)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty (Hearing Loss) in UK Biobank<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 44 genetic variants associated with age-related hearing impairment.<\/p>\n\n\n\n

DESCRIPTION: <\/strong>Hearing loss is one of the most common age-associated medical conditions. It has been associated with social isolation, depression, and can be a risk factor for dementia. Though believed to be highly heritable, the genetic factors associated with a predisposition to age-related hearing impairment (ARHI) remain largely unknown. This genome-wide association study discovered 44 variants associated with ARHI after examining more than 250,000 individuals of European ancestry aged 40 to 65. Many of these variants are near genes that play a role in development and function of the inner ear. Some of the variants have been previously associated with multiple personality disorder and psychological traits. These variants explain 10-20% of the heritability of ARHI.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Depending on the severity of the hearing loss, you can use hearing aids, cochlear implants, bone anchored hearing systems, assistive listening devices, and learn how to lip or speech read. [SOURCE<\/a>]<\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>.<\/p>\n\n\n\n

\"This<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

VARIANTS ASSOCIATED WITH HEARING LOSS:<\/strong> rs36062310, rs6453022, rs759016271, rs6890164, rs7951935, rs35186928, rs9493627, rs132929, rs5756795, rs1566129, rs35414371, rs12225399, rs55635402, rs62033400, rs13277721, rs62188635, rs2236401, rs4947828, rs6597883, rs34442808, rs835267, rs4948502, rs10824108, rs12027345, rs217289, rs13093972, rs62015206, rs10475169, rs17671352, rs7525101, rs12938775, rs76837345, rs9366417, rs3890736, rs143282422, rs9691831, rs141403654, rs4611552, rs12552, rs10927035<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
Hearing Loss Prevention<\/a>
The Ear<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> October 6, 2019<\/p>\n\n\n\n


<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty (Hearing Loss) in UK Biobank SUMMARY: Identification of 44 genetic variants associated with age-related hearing impairment. DESCRIPTION: Hearing loss is one of the most common age-associated …<\/p>\n

Hearing Loss (Wells, 2019)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1090,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1089","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe genetics of hearing loss (Wells, 2019)<\/title>\n<meta name=\"description\" content=\"Upload your DNA data to explore genetic variants linked to hearing loss (Wells, 2019) and discover your polygenic score on Nebula Genomics.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The genetics of hearing loss (Wells, 2019)\" \/>\n<meta property=\"og:description\" content=\"Upload your DNA data to explore genetic variants linked to hearing loss (Wells, 2019) and discover your polygenic score on Nebula Genomics.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/\" \/>\n<meta property=\"og:site_name\" content=\"Nebula Genomics Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/nebulagenomics\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-16T04:00:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-27T06:56:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/freshh-connection-tKNB4iW3GT8-unsplash-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"616\" \/>\n\t<meta property=\"og:image:height\" content=\"924\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Garrett Dunlap, B.S.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:site\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Garrett Dunlap, B.S.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/\"},\"author\":{\"name\":\"Garrett Dunlap, B.S.\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\"},\"headline\":\"Hearing Loss (Wells, 2019)\",\"datePublished\":\"2020-04-16T04:00:23+00:00\",\"dateModified\":\"2021-01-27T06:56:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/\"},\"wordCount\":240,\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"articleSection\":[\"Reports\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/\",\"url\":\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/\",\"name\":\"The genetics of hearing loss (Wells, 2019)\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/#website\"},\"datePublished\":\"2020-04-16T04:00:23+00:00\",\"dateModified\":\"2021-01-27T06:56:05+00:00\",\"description\":\"Upload your DNA data to explore genetic variants linked to hearing loss (Wells, 2019) and discover your polygenic score on Nebula Genomics.\",\"breadcrumb\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/nebula.org\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hearing Loss (Wells, 2019)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/nebula.org\/blog\/#website\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"name\":\"Nebula Genomics Blog\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/nebula.org\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/nebula.org\/blog\/#organization\",\"name\":\"Nebula Genomics\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Nebula Genomics\"},\"image\":{\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/facebook.com\/nebulagenomics\",\"https:\/\/twitter.com\/nebulagenomics\",\"https:\/\/www.instagram.com\/nebulagenomics\/\",\"https:\/\/www.linkedin.com\/company\/nebula-genomics\/\",\"https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\",\"name\":\"Garrett Dunlap, B.S.\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"caption\":\"Garrett Dunlap, B.S.\"},\"description\":\"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.\",\"sameAs\":[\"https:\/\/nebula.org\/whole-genome-sequencing\/\"],\"url\":\"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The genetics of hearing loss (Wells, 2019)","description":"Upload your DNA data to explore genetic variants linked to hearing loss (Wells, 2019) and discover your polygenic score on Nebula Genomics.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/","og_locale":"en_US","og_type":"article","og_title":"The genetics of hearing loss (Wells, 2019)","og_description":"Upload your DNA data to explore genetic variants linked to hearing loss (Wells, 2019) and discover your polygenic score on Nebula Genomics.","og_url":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/","og_site_name":"Nebula Genomics Blog","article_publisher":"https:\/\/facebook.com\/nebulagenomics","article_published_time":"2020-04-16T04:00:23+00:00","article_modified_time":"2021-01-27T06:56:05+00:00","og_image":[{"width":616,"height":924,"url":"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/freshh-connection-tKNB4iW3GT8-unsplash-scaled.jpg","type":"image\/jpeg"}],"author":"Garrett Dunlap, B.S.","twitter_card":"summary_large_image","twitter_creator":"@nebulagenomics","twitter_site":"@nebulagenomics","twitter_misc":{"Written by":"Garrett Dunlap, B.S.","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/#article","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/"},"author":{"name":"Garrett Dunlap, B.S.","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e"},"headline":"Hearing Loss (Wells, 2019)","datePublished":"2020-04-16T04:00:23+00:00","dateModified":"2021-01-27T06:56:05+00:00","mainEntityOfPage":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/"},"wordCount":240,"publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"articleSection":["Reports"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/","url":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/","name":"The genetics of hearing loss (Wells, 2019)","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/#website"},"datePublished":"2020-04-16T04:00:23+00:00","dateModified":"2021-01-27T06:56:05+00:00","description":"Upload your DNA data to explore genetic variants linked to hearing loss (Wells, 2019) and discover your polygenic score on Nebula Genomics.","breadcrumb":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/nebula.org\/blog\/genetics-of-hearing-loss-wells-2019\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/nebula.org\/blog\/"},{"@type":"ListItem","position":2,"name":"Hearing Loss (Wells, 2019)"}]},{"@type":"WebSite","@id":"https:\/\/nebula.org\/blog\/#website","url":"https:\/\/nebula.org\/blog\/","name":"Nebula Genomics Blog","description":"","publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nebula.org\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nebula.org\/blog\/#organization","name":"Nebula Genomics","url":"https:\/\/nebula.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Nebula Genomics"},"image":{"@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/facebook.com\/nebulagenomics","https:\/\/twitter.com\/nebulagenomics","https:\/\/www.instagram.com\/nebulagenomics\/","https:\/\/www.linkedin.com\/company\/nebula-genomics\/","https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics"]},{"@type":"Person","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e","name":"Garrett Dunlap, B.S.","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","caption":"Garrett Dunlap, B.S."},"description":"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/comments?post=1089"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1089\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media\/1090"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media?parent=1089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/categories?post=1089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/tags?post=1089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}