{"id":1140,"date":"2020-04-09T23:22:00","date_gmt":"2020-04-10T03:22:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1140"},"modified":"2021-01-27T01:56:07","modified_gmt":"2021-01-27T06:56:07","slug":"genetics-of-nasal-polyps-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/","title":{"rendered":"Nasal Polyps (Kristjansson, 2019)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 10 genetic variants associated with the development of nasal polyps.<\/p>\n\n\n\n

OVERVIEW:  <\/strong>Nasal polyps are growths that form along the lining of the nasal cavity. While not cancerous, they can eventually cause blockage of the nasal passage leading to breathing problems and a loss of smell. At the time of the publication of this study, no genetic risk factors for nasal polyp were known. This study examined the genomes of over 700,000 individuals of European descent and discovered 10 genetic variants, many near genes that play a role in inflammation. It was previously reported that chronic nasal inflammation increases the risk of developing nasal polyps. The findings of this study shed some light on this connection.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Because dry air can trigger inflammation of the nasal cavity, the use of a humidifier may help prevent recurring inflammation and the development of polyps. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the\u00a0Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"nasal<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

POLYP-ASSOCIATED VARIANTS:<\/strong> rs1391371, rs1888909, rs1837253, rs34210653, rs1444782, rs17718444, rs338598, rs6543124, rs174535, rs1050152<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
Nasal Polyps<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> December 26, 2019<\/p>\n\n\n\n


<\/p>\n\n\n\n


<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis SUMMARY: Identification of 10 genetic variants associated with the development of nasal polyps. OVERVIEW:  Nasal polyps are growths that form along the lining of the nasal …<\/p>\n

Nasal Polyps (Kristjansson, 2019)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1142,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1140","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe genetics of nasal polyps (Kristjansson, 2019)<\/title>\n<meta name=\"description\" content=\"Upload your DNA data, explore genetic variants linked to nasal polyps (Kristjansson, 2019), and discover your polygenic score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The genetics of nasal polyps (Kristjansson, 2019)\" \/>\n<meta property=\"og:description\" content=\"Upload your DNA data, explore genetic variants linked to nasal polyps (Kristjansson, 2019), and discover your polygenic score.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/\" \/>\n<meta property=\"og:site_name\" content=\"Nebula Genomics Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/nebulagenomics\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-10T03:22:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-27T06:56:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/alexander-krivitskiy-ELzGgp2wOkE-unsplash-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"616\" \/>\n\t<meta property=\"og:image:height\" content=\"924\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Garrett Dunlap, B.S.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:site\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Garrett Dunlap, B.S.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/\"},\"author\":{\"name\":\"Garrett Dunlap, B.S.\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\"},\"headline\":\"Nasal Polyps (Kristjansson, 2019)\",\"datePublished\":\"2020-04-10T03:22:00+00:00\",\"dateModified\":\"2021-01-27T06:56:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/\"},\"wordCount\":190,\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"articleSection\":[\"Reports\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/\",\"url\":\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/\",\"name\":\"The genetics of nasal polyps (Kristjansson, 2019)\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/#website\"},\"datePublished\":\"2020-04-10T03:22:00+00:00\",\"dateModified\":\"2021-01-27T06:56:07+00:00\",\"description\":\"Upload your DNA data, explore genetic variants linked to nasal polyps (Kristjansson, 2019), and discover your polygenic score.\",\"breadcrumb\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/nebula.org\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Nasal Polyps (Kristjansson, 2019)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/nebula.org\/blog\/#website\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"name\":\"Nebula Genomics Blog\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/nebula.org\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/nebula.org\/blog\/#organization\",\"name\":\"Nebula Genomics\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Nebula Genomics\"},\"image\":{\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/facebook.com\/nebulagenomics\",\"https:\/\/twitter.com\/nebulagenomics\",\"https:\/\/www.instagram.com\/nebulagenomics\/\",\"https:\/\/www.linkedin.com\/company\/nebula-genomics\/\",\"https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\",\"name\":\"Garrett Dunlap, B.S.\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"caption\":\"Garrett Dunlap, B.S.\"},\"description\":\"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.\",\"sameAs\":[\"https:\/\/nebula.org\/whole-genome-sequencing\/\"],\"url\":\"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The genetics of nasal polyps (Kristjansson, 2019)","description":"Upload your DNA data, explore genetic variants linked to nasal polyps (Kristjansson, 2019), and discover your polygenic score.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/","og_locale":"en_US","og_type":"article","og_title":"The genetics of nasal polyps (Kristjansson, 2019)","og_description":"Upload your DNA data, explore genetic variants linked to nasal polyps (Kristjansson, 2019), and discover your polygenic score.","og_url":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/","og_site_name":"Nebula Genomics Blog","article_publisher":"https:\/\/facebook.com\/nebulagenomics","article_published_time":"2020-04-10T03:22:00+00:00","article_modified_time":"2021-01-27T06:56:07+00:00","og_image":[{"width":616,"height":924,"url":"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/alexander-krivitskiy-ELzGgp2wOkE-unsplash-scaled.jpg","type":"image\/jpeg"}],"author":"Garrett Dunlap, B.S.","twitter_card":"summary_large_image","twitter_creator":"@nebulagenomics","twitter_site":"@nebulagenomics","twitter_misc":{"Written by":"Garrett Dunlap, B.S.","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/#article","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/"},"author":{"name":"Garrett Dunlap, B.S.","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e"},"headline":"Nasal Polyps (Kristjansson, 2019)","datePublished":"2020-04-10T03:22:00+00:00","dateModified":"2021-01-27T06:56:07+00:00","mainEntityOfPage":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/"},"wordCount":190,"publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"articleSection":["Reports"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/","url":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/","name":"The genetics of nasal polyps (Kristjansson, 2019)","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/#website"},"datePublished":"2020-04-10T03:22:00+00:00","dateModified":"2021-01-27T06:56:07+00:00","description":"Upload your DNA data, explore genetic variants linked to nasal polyps (Kristjansson, 2019), and discover your polygenic score.","breadcrumb":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/nebula.org\/blog\/genetics-of-nasal-polyps-2019\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/nebula.org\/blog\/"},{"@type":"ListItem","position":2,"name":"Nasal Polyps (Kristjansson, 2019)"}]},{"@type":"WebSite","@id":"https:\/\/nebula.org\/blog\/#website","url":"https:\/\/nebula.org\/blog\/","name":"Nebula Genomics Blog","description":"","publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nebula.org\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nebula.org\/blog\/#organization","name":"Nebula Genomics","url":"https:\/\/nebula.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Nebula Genomics"},"image":{"@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/facebook.com\/nebulagenomics","https:\/\/twitter.com\/nebulagenomics","https:\/\/www.instagram.com\/nebulagenomics\/","https:\/\/www.linkedin.com\/company\/nebula-genomics\/","https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics"]},{"@type":"Person","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e","name":"Garrett Dunlap, B.S.","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","caption":"Garrett Dunlap, B.S."},"description":"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/comments?post=1140"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1140\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media\/1142"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media?parent=1140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/categories?post=1140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/tags?post=1140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}