{"id":1186,"date":"2020-04-09T23:52:00","date_gmt":"2020-04-10T03:52:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1186"},"modified":"2021-01-27T01:56:07","modified_gmt":"2021-01-27T06:56:07","slug":"genetics-of-resting-heart-rate-eppinga-2016","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/","title":{"rendered":"Resting Heart Rate (Eppinga, 2016)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality<\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 64 genetic loci that are associated with resting heart rate, a key predictor of cardiovascular health.<\/p>\n\n\n\n

OVERVIEW: \u00a0<\/strong>The heart rate is the number of times that the heart beats per minute. In adults, the resting heart rate is typically 60 to 100 beats per minute. A lower resting heart rate indicates a more efficient function of the heart and better health. People who are physically very fit, for example professional runners, may have a resting heart rate as low as 40 beats per minute! Conversely, an elevated resting heart rate can be a predictor of high blood pressure, heart disease, and heart failure. This study aimed to better understand the genetic influence on the trait by analyzing the genomes of over 265,000 individuals of various ancestries. The study identified 64 genetic loci, including 46 novel loci, that correlate with resting heart rate. Together, all the identified genetic variants explain around 2.5% of the total variance in the trait. The study also found that an elevated resting heart rate is linked to an increased mortality risk. A fast genetically predicted heart rate was associated with a reduction of life expectancy by multiple years.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Physical activity, such as running, biking, or swimming, is an effective waya to decrease resting heart rate. Get your heart pumping today to decrease your resting heart rate and potentially live a longer, healthier life! [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the\u00a0Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"resting<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

RESTING HEART RATE-ASSOCIATED VARIANTS:<\/strong> rs422068, rs151041685, rs6123471, rs1320761, rs3951016, rs4963772, rs17881696, rs1994135, rs7173389, rs41317993, rs174536, rs17201923, rs7612445, rs272564, rs180239, rs907683, rs1288967, rs2283274, rs867400, rs17180489, rs73158705, rs7194801, rs2152735, rs3915499, rs13002735, rs75190942, rs138186803, rs4868243, rs1260326, rs2076028, rs62172372, rs10739663, rs236349, rs56233017, rs12501032, rs1483890, rs61735998, rs6845865, rs79121763, rs1468333, rs3749237, rs11920570, rs12576326, rs4608502, rs58437978, rs16974196, rs11454451, rs41312411, rs145358377, rs13165531, rs12721051, rs11563648, rs12579753, rs564190295, rs11083258, rs10880689, rs1050288, rs10841486, rs2358740, rs4900069, rs41748, rs12713404, rs17265513, rs748802, rs11081761, rs1549118<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
The Heart (Video)<\/a>
Heart Rate<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> December 19, 2019<\/p>\n\n\n\n


<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality SUMMARY: Identification of 64 genetic loci that are associated with resting heart rate, a key predictor of cardiovascular health. OVERVIEW: \u00a0The heart …<\/p>\n

Resting Heart Rate (Eppinga, 2016)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1187,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1186","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe genetics of resting heart rate (Eppinga, 2016)<\/title>\n<meta name=\"description\" content=\"Upload your DNA data, explore genetic variants linked to resting heart rate (Eppinga, 2016), and discover your polygenic score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The genetics of resting heart rate (Eppinga, 2016)\" \/>\n<meta property=\"og:description\" content=\"Upload your DNA data, explore genetic variants linked to resting heart rate (Eppinga, 2016), and discover your polygenic score.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/\" \/>\n<meta property=\"og:site_name\" content=\"Nebula Genomics Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/nebulagenomics\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-10T03:52:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-27T06:56:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2019\/12\/chander-r-z4WH11FMfIQ-unsplash-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"924\" \/>\n\t<meta property=\"og:image:height\" content=\"615\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Garrett Dunlap, B.S.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:site\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Garrett Dunlap, B.S.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/\"},\"author\":{\"name\":\"Garrett Dunlap, B.S.\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\"},\"headline\":\"Resting Heart Rate (Eppinga, 2016)\",\"datePublished\":\"2020-04-10T03:52:00+00:00\",\"dateModified\":\"2021-01-27T06:56:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/\"},\"wordCount\":338,\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"articleSection\":[\"Reports\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/\",\"url\":\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/\",\"name\":\"The genetics of resting heart rate (Eppinga, 2016)\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/#website\"},\"datePublished\":\"2020-04-10T03:52:00+00:00\",\"dateModified\":\"2021-01-27T06:56:07+00:00\",\"description\":\"Upload your DNA data, explore genetic variants linked to resting heart rate (Eppinga, 2016), and discover your polygenic score.\",\"breadcrumb\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/nebula.org\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Resting Heart Rate (Eppinga, 2016)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/nebula.org\/blog\/#website\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"name\":\"Nebula Genomics Blog\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/nebula.org\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/nebula.org\/blog\/#organization\",\"name\":\"Nebula Genomics\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Nebula Genomics\"},\"image\":{\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/facebook.com\/nebulagenomics\",\"https:\/\/twitter.com\/nebulagenomics\",\"https:\/\/www.instagram.com\/nebulagenomics\/\",\"https:\/\/www.linkedin.com\/company\/nebula-genomics\/\",\"https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\",\"name\":\"Garrett Dunlap, B.S.\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"caption\":\"Garrett Dunlap, B.S.\"},\"description\":\"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.\",\"sameAs\":[\"https:\/\/nebula.org\/whole-genome-sequencing\/\"],\"url\":\"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The genetics of resting heart rate (Eppinga, 2016)","description":"Upload your DNA data, explore genetic variants linked to resting heart rate (Eppinga, 2016), and discover your polygenic score.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/","og_locale":"en_US","og_type":"article","og_title":"The genetics of resting heart rate (Eppinga, 2016)","og_description":"Upload your DNA data, explore genetic variants linked to resting heart rate (Eppinga, 2016), and discover your polygenic score.","og_url":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/","og_site_name":"Nebula Genomics Blog","article_publisher":"https:\/\/facebook.com\/nebulagenomics","article_published_time":"2020-04-10T03:52:00+00:00","article_modified_time":"2021-01-27T06:56:07+00:00","og_image":[{"width":924,"height":615,"url":"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2019\/12\/chander-r-z4WH11FMfIQ-unsplash-scaled.jpg","type":"image\/jpeg"}],"author":"Garrett Dunlap, B.S.","twitter_card":"summary_large_image","twitter_creator":"@nebulagenomics","twitter_site":"@nebulagenomics","twitter_misc":{"Written by":"Garrett Dunlap, B.S.","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/#article","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/"},"author":{"name":"Garrett Dunlap, B.S.","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e"},"headline":"Resting Heart Rate (Eppinga, 2016)","datePublished":"2020-04-10T03:52:00+00:00","dateModified":"2021-01-27T06:56:07+00:00","mainEntityOfPage":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/"},"wordCount":338,"publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"articleSection":["Reports"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/","url":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/","name":"The genetics of resting heart rate (Eppinga, 2016)","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/#website"},"datePublished":"2020-04-10T03:52:00+00:00","dateModified":"2021-01-27T06:56:07+00:00","description":"Upload your DNA data, explore genetic variants linked to resting heart rate (Eppinga, 2016), and discover your polygenic score.","breadcrumb":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/nebula.org\/blog\/genetics-of-resting-heart-rate-eppinga-2016\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/nebula.org\/blog\/"},{"@type":"ListItem","position":2,"name":"Resting Heart Rate (Eppinga, 2016)"}]},{"@type":"WebSite","@id":"https:\/\/nebula.org\/blog\/#website","url":"https:\/\/nebula.org\/blog\/","name":"Nebula Genomics Blog","description":"","publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nebula.org\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nebula.org\/blog\/#organization","name":"Nebula Genomics","url":"https:\/\/nebula.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Nebula Genomics"},"image":{"@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/facebook.com\/nebulagenomics","https:\/\/twitter.com\/nebulagenomics","https:\/\/www.instagram.com\/nebulagenomics\/","https:\/\/www.linkedin.com\/company\/nebula-genomics\/","https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics"]},{"@type":"Person","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e","name":"Garrett Dunlap, B.S.","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","caption":"Garrett Dunlap, B.S."},"description":"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/comments?post=1186"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1186\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media\/1187"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media?parent=1186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/categories?post=1186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/tags?post=1186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}