{"id":1217,"date":"2020-04-16T00:00:20","date_gmt":"2020-04-16T04:00:20","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1217"},"modified":"2021-01-27T01:56:06","modified_gmt":"2021-01-27T06:56:06","slug":"genetics-of-accelerated-aging-gibson-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/","title":{"rendered":"Accelerated Aging (Gibson, 2019)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>A meta-analysis of genome-wide association studies of epigenetic age acceleration<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Discovery of 10 genetic variants associated with accelerated aging.<\/p>\n\n\n\n

OVERVIEW:  <\/strong>Biological age\u201d is a measure of how well a human body is functioning relative to its actual calendar age. Studies have shown that the biological age can be estimated by measuring DNA modifications, known as methylations, across the genome. The presence of these aging-associated modifications is influenced by environmental (e.g. lifestyle) as well as genetic factors. This genome-wide association study examined the genomes of almost 13,500 individuals of European ancestry and discovered 10 genetic variants that are associated with DNA methylation profiles that are linked to accelerated biological aging. Most of the discovered variants are near genes that play a role in the metabolism or the immune system.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Biological aging can be slowed down by maintaining a healthy diet, exercising regularly and minimizing stress. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

AGING-ASSOCIATED VARIANTS:<\/strong> rs76244256, rs7744541, rs10778517, rs388649, rs2736099, rs1011267, rs4712953, rs6440667, rs79070372, rs62078811<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
The epigenetic clock (Video)<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> December 5, 2019
<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: A meta-analysis of genome-wide association studies of epigenetic age acceleration SUMMARY: Discovery of 10 genetic variants associated with accelerated aging. OVERVIEW:  Biological age\u201d is a measure of how well a human body is functioning relative to its actual …<\/p>\n

Accelerated Aging (Gibson, 2019)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1218,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1217","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe genetics of accelerated aging (Gibson, 2019)<\/title>\n<meta name=\"description\" content=\"Upload your DNA data to explore genetic variants linked to accelerated aging (Gibson, 2019) and discover your polygenic score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The genetics of accelerated aging (Gibson, 2019)\" \/>\n<meta property=\"og:description\" content=\"Upload your DNA data to explore genetic variants linked to accelerated aging (Gibson, 2019) and discover your polygenic score.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/\" \/>\n<meta property=\"og:site_name\" content=\"Nebula Genomics Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/nebulagenomics\" \/>\n<meta property=\"article:published_time\" content=\"2020-04-16T04:00:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-27T06:56:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2019\/12\/ravi-patel-VMGAbeeJTKo-unsplash-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"924\" \/>\n\t<meta property=\"og:image:height\" content=\"616\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Garrett Dunlap, B.S.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:site\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Garrett Dunlap, B.S.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/\"},\"author\":{\"name\":\"Garrett Dunlap, B.S.\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\"},\"headline\":\"Accelerated Aging (Gibson, 2019)\",\"datePublished\":\"2020-04-16T04:00:20+00:00\",\"dateModified\":\"2021-01-27T06:56:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/\"},\"wordCount\":184,\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"articleSection\":[\"Reports\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/\",\"url\":\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/\",\"name\":\"The genetics of accelerated aging (Gibson, 2019)\",\"isPartOf\":{\"@id\":\"https:\/\/nebula.org\/blog\/#website\"},\"datePublished\":\"2020-04-16T04:00:20+00:00\",\"dateModified\":\"2021-01-27T06:56:06+00:00\",\"description\":\"Upload your DNA data to explore genetic variants linked to accelerated aging (Gibson, 2019) and discover your polygenic score.\",\"breadcrumb\":{\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/nebula.org\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Accelerated Aging (Gibson, 2019)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/nebula.org\/blog\/#website\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"name\":\"Nebula Genomics Blog\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/nebula.org\/blog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/nebula.org\/blog\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/nebula.org\/blog\/#organization\",\"name\":\"Nebula Genomics\",\"url\":\"https:\/\/nebula.org\/blog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Nebula Genomics\"},\"image\":{\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/facebook.com\/nebulagenomics\",\"https:\/\/twitter.com\/nebulagenomics\",\"https:\/\/www.instagram.com\/nebulagenomics\/\",\"https:\/\/www.linkedin.com\/company\/nebula-genomics\/\",\"https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e\",\"name\":\"Garrett Dunlap, B.S.\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g\",\"caption\":\"Garrett Dunlap, B.S.\"},\"description\":\"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.\",\"sameAs\":[\"https:\/\/nebula.org\/whole-genome-sequencing\/\"],\"url\":\"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The genetics of accelerated aging (Gibson, 2019)","description":"Upload your DNA data to explore genetic variants linked to accelerated aging (Gibson, 2019) and discover your polygenic score.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/","og_locale":"en_US","og_type":"article","og_title":"The genetics of accelerated aging (Gibson, 2019)","og_description":"Upload your DNA data to explore genetic variants linked to accelerated aging (Gibson, 2019) and discover your polygenic score.","og_url":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/","og_site_name":"Nebula Genomics Blog","article_publisher":"https:\/\/facebook.com\/nebulagenomics","article_published_time":"2020-04-16T04:00:20+00:00","article_modified_time":"2021-01-27T06:56:06+00:00","og_image":[{"width":924,"height":616,"url":"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2019\/12\/ravi-patel-VMGAbeeJTKo-unsplash-scaled.jpg","type":"image\/jpeg"}],"author":"Garrett Dunlap, B.S.","twitter_card":"summary_large_image","twitter_creator":"@nebulagenomics","twitter_site":"@nebulagenomics","twitter_misc":{"Written by":"Garrett Dunlap, B.S.","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/#article","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/"},"author":{"name":"Garrett Dunlap, B.S.","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e"},"headline":"Accelerated Aging (Gibson, 2019)","datePublished":"2020-04-16T04:00:20+00:00","dateModified":"2021-01-27T06:56:06+00:00","mainEntityOfPage":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/"},"wordCount":184,"publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"articleSection":["Reports"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/","url":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/","name":"The genetics of accelerated aging (Gibson, 2019)","isPartOf":{"@id":"https:\/\/nebula.org\/blog\/#website"},"datePublished":"2020-04-16T04:00:20+00:00","dateModified":"2021-01-27T06:56:06+00:00","description":"Upload your DNA data to explore genetic variants linked to accelerated aging (Gibson, 2019) and discover your polygenic score.","breadcrumb":{"@id":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/nebula.org\/blog\/genetics-of-accelerated-aging-gibson-2019\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/nebula.org\/blog\/"},{"@type":"ListItem","position":2,"name":"Accelerated Aging (Gibson, 2019)"}]},{"@type":"WebSite","@id":"https:\/\/nebula.org\/blog\/#website","url":"https:\/\/nebula.org\/blog\/","name":"Nebula Genomics Blog","description":"","publisher":{"@id":"https:\/\/nebula.org\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/nebula.org\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/nebula.org\/blog\/#organization","name":"Nebula Genomics","url":"https:\/\/nebula.org\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Nebula Genomics"},"image":{"@id":"https:\/\/nebula.org\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/facebook.com\/nebulagenomics","https:\/\/twitter.com\/nebulagenomics","https:\/\/www.instagram.com\/nebulagenomics\/","https:\/\/www.linkedin.com\/company\/nebula-genomics\/","https:\/\/en.wikipedia.org\/wiki\/Nebula_Genomics"]},{"@type":"Person","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/b7bd0a490f115d1d931c33eed922af4e","name":"Garrett Dunlap, B.S.","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/nebula.org\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","caption":"Garrett Dunlap, B.S."},"description":"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/comments?post=1217"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/posts\/1217\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media\/1218"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/media?parent=1217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/categories?post=1217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/wp-json\/wp\/v2\/tags?post=1217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}