{"id":1330,"date":"2020-04-16T00:00:00","date_gmt":"2020-04-16T04:00:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1330"},"modified":"2021-01-27T01:56:07","modified_gmt":"2021-01-27T06:56:07","slug":"genetics-of-mosaic-loss-of-chromosome-y-terao-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-mosaic-loss-of-chromosome-y-terao-2019\/","title":{"rendered":"Mosaic Loss of Chromosome Y (Terao, 2019)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 46 genetic variants associated with mosaic loss of chromosome Y (mLOY).<\/p>\n\n\n\n

DESCRIPTION: <\/strong>Cells in the human body store genetic information in 23 pairs of chromosomes. mLOY is a male-specific condition characterized by the loss of chromosome Y by some cells. mLOY has been linked to various medical conditions, including cancer, and is most commonly observed in the white blood cells of ageing men. This genome-wide association study analyzed the genetic data of 95,380 Japanese men to better understand the genetic factors that contribute to this condition. The study discovered 46 genetic variants of which 35 are novel, and collectively these variants explain an estimated 9% of the heritability of mLOY. Many of the identified genetic variants are near genes that are active in blood stem cells.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Studies have shown that smoking may significantly increase the risk of mosaic loss of chromosome Y. There is good news for smokers looking to quit \u2013 the same research showed that previous smokers were not any more likely to have Y chromosome loss than never smokers. [SOURCE<\/a>]<\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>.<\/p>\n\n\n\n

\"Example<\/a><\/figure>\n\n\n\n

mLOY-ASSOCIATED VARIANTS:<\/strong> rs56116444, rs80277818, rs2842873, rs72698721, rs59543286, rs4709819, rs227079, rs4721217, rs2237896, rs78997619, rs55727837, rs34324, rs11769630, rs4681200, rs4683900, rs10849448, rs728739, rs871134, rs35355140, rs138423884, rs34468831, rs10948011, rs9921295, rs17049722, rs11251, rs77406149, rs2646425, rs2811487, rs1859259, rs12668837, rs34778241, rs2853677, rs9299129, rs527504, rs77874075, rs10692222, rs548509555, rs117587217, rs201753350, rs12225799, rs79058858, rs74843651, rs189309686, rs2804301, rs2979469<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
Sex Chromosomes<\/a>
Hematopoietic Stem Cell<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> October 24, 2019<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation SUMMARY: Identification of 46 genetic variants associated with mosaic loss of chromosome Y (mLOY). DESCRIPTION: Cells in the human body store genetic information in …<\/p>\n

Mosaic Loss of Chromosome Y (Terao, 2019)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1331,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe genetics of mosaic loss of chromosome Y (Terao, 2019)<\/title>\n<meta name=\"description\" content=\"Upload your DNA data to explore genetic variants linked to mosaic loss of chromosome Y (Terao, 2019) and discover your polygenic score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/genetics-of-mosaic-loss-of-chromosome-y-terao-2019\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The genetics of mosaic loss of chromosome Y (Terao, 2019)\" \/>\n<meta property=\"og:description\" content=\"Upload your DNA data to explore genetic variants linked to mosaic loss of chromosome Y (Terao, 2019) and discover your polygenic score.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nebula.org\/blog\/genetics-of-mosaic-loss-of-chromosome-y-terao-2019\/\" 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