{"id":1376,"date":"2020-04-09T12:57:00","date_gmt":"2020-04-09T16:57:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1376"},"modified":"2021-01-27T01:56:09","modified_gmt":"2021-01-27T06:56:09","slug":"genetics-of-cutaneous-squamous-cell-carcinoma-sarin-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-cutaneous-squamous-cell-carcinoma-sarin-2020\/","title":{"rendered":"Cutaneous Squamous Cell Carcinoma (Sarin, 2020)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 8 novel genomic variants associated with cutaneous squamous cell<\/em> carcinoma (SCC).<\/p>\n\n\n\n

OVERVIEW:  <\/strong>Cutaneous squamous cell<\/em> carcinoma (SCC) is the second most common form of skin cancer. Most SCCs can be easily removed, but if left untreated, they can grow deeper into the skin and the cancer cells can spread to other parts of the body. This study combined data from nearly 700,000 individuals of European descent to identify genetic variants associated with SCC. The researchers discovered 14 previously known genetic variants, as well as 8 novel variants. Collectively, these genetic variants explain roughly 9% of the heritability of SCC. Many of the variants are near genes related to skin functions and the immune system, as well as genes known to play a role in other cancers.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> To reduce your risk of skin cancer, dermatologists recommend seeking shade when appropriate, wearing protective clothing and using sunscreen. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the\u00a0Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"Squamous<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

ANALYZED VARIANTS:<\/strong> rs12203592, rs1805007, rs6059655, rs1126809, rs35407, rs4455710, rs10810657, rs6791479, rs1800407, rs7939541, rs57994353, rs62246017, rs657187, rs7834300, rs10200279, rs10944479, rs10399947, rs117132860, rs721199, rs1325118<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
Squamous Cell Carcinoma Overview<\/a>
Skin cancer<\/a>
Skin cancers (Video)<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> February 22, 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma SUMMARY: Identification of 8 novel genomic variants associated with cutaneous squamous cell carcinoma (SCC). OVERVIEW:  Cutaneous squamous cell carcinoma (SCC) is the second most common form of skin cancer. Most …<\/p>\n

Cutaneous Squamous Cell Carcinoma (Sarin, 2020)<\/span> Read More 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