{"id":1408,"date":"2020-04-09T11:25:00","date_gmt":"2020-04-09T15:25:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1408"},"modified":"2022-05-31T09:36:56","modified_gmt":"2022-05-31T13:36:56","slug":"genetics-of-telomere-length-li-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-telomere-length-li-2020\/","title":{"rendered":"Telomere Length (Li, 2020)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 6 novel genomic regions associated with leukocyte telomere length.<\/p>\n\n\n\n

OVERVIEW: <\/strong>Telomeres are protective caps at the ends of chromosomes<\/em> which get shorter as our bodies age. Telomere length (TL) is typically measured in leukocytes<\/em> from blood samples. It can be used as a biomarker<\/em> for aging and age-related diseases like coronary artery disease and some cancers. This genome-wide meta-analysis<\/em> of over 78,000 individuals of European descent sought to identify genomic regions associated with leukocyte TL to better understand how telomere length is regulated. The study reported 20 genomic regions associated with leukocyte TL, including 6 that are reported for the first time. Some of the genes in these regions have been previously linked to DNA damage repair.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Regular exercise has been shown to extend telomere length. Drinking alcohol, smoking, and eating red meats fried in oil accelerates the shortening of telomeres. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"Telomere<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

LENGTH-ASSOCIATED VARIANTS: <\/strong>rs10936600, rs7705526, rs2853677, rs4691895, rs9419958, rs75691080, rs59294613, rs8105767, rs73624724, rs3219104, rs2736176, rs3785074, rs7194734, rs34978822, rs34991172, rs228595, rs2302588, rs13137667, rs55749605, rs62053580<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
Telomeres<\/a>
Telomeres and telomerase<\/a>
What is a telomere? (Video)<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> March 9, 2020<\/p>\n\n\n\n

Interested in learning more about your telomere length? You might like our TeloYears<\/a> review. <\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length SUMMARY: Identification of 6 novel genomic regions associated with leukocyte telomere length. OVERVIEW: Telomeres are protective caps at the ends of chromosomes which get shorter as our bodies …<\/p>\n

Telomere Length (Li, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1406,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1408","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe 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