{"id":1447,"date":"2020-03-29T08:57:00","date_gmt":"2020-03-29T12:57:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1447"},"modified":"2021-01-27T01:56:12","modified_gmt":"2021-01-27T06:56:12","slug":"genetics-of-sars-coronavirus-infection-ching-2010","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-sars-coronavirus-infection-ching-2010\/","title":{"rendered":"SARS coronavirus infection (Ching, 2010)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>Significance of the Myxovirus Resistance A (MxA) Gene \u2014 123C>A Single-Nucleotide Polymorphism in Suppressed Interferon \u03b2 Induction of Severe Acute Respiratory Syndrome Coronavirus Infection<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of a genetic variant associated with a decreased risk of SARS coronavirus<\/em> infection.<\/p>\n\n\n\n

OVERVIEW: <\/strong>The severe acute respiratory syndrome (SARS) coronavirus<\/em> emerged in 2003 in China. In little over a year, it infected 8000 people and caused over 900 deaths across the world. Typical symptoms include high fever, headache, and a dry cough. Previous studies have shown that interferons<\/em> can inhibit the replication of the SARS coronavirus<\/em> by inducing production of antiviral proteins like MxA. This study demonstrated that a genetic variant (rs17000900) near the MxA gene influences its activity when cells are exposed to interferons<\/em>. The study also examined the genetic information of over 1200 individuals of Chinese descent and established a relationship between this genetic variant and risk of SARS coronavirus<\/em> infection. The results suggest that the A allele of the rs17000900 variant is linked to a decreased susceptibility to SARS coronavirus<\/em> infection. (Note: This study is not a genome-wide association study. Only a few variants were genotyped selectively.)<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Coronaviruses are also responsible for the MERS (Middle East Respiratory Syndrome) pandemic in the early 2010s. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"Coronavirus<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

SARS CORONAVIRUS ANALYZED VARIANTS:<\/strong> rs17000900<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
Severe acute respiratory syndrome (SARS)<\/a>
Lesson learned from SARS outbreak (Video)<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> March 23, 2020<\/p>\n\n\n\n

For updates on the genetics of COVID-19 visit: https:\/\/nebula.org\/blog\/category\/science\/<\/a><\/p>\n\n\n\n

You can learn more about at-home coronavirus tests<\/a> in our review!<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: Significance of the Myxovirus Resistance A (MxA) Gene \u2014 123C>A Single-Nucleotide Polymorphism in Suppressed Interferon \u03b2 Induction of Severe Acute Respiratory Syndrome Coronavirus Infection SUMMARY: Identification of a genetic variant associated with a decreased risk of SARS coronavirus infection. OVERVIEW: …<\/p>\n

SARS coronavirus infection (Ching, 2010)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1454,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe 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