{"id":1606,"date":"2020-03-31T10:30:04","date_gmt":"2020-03-31T14:30:04","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1606"},"modified":"2021-01-27T01:56:12","modified_gmt":"2021-01-27T06:56:12","slug":"pelvic-organ-prolapse-olafsdottir-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pelvic-organ-prolapse-olafsdottir-2020\/","title":{"rendered":"Pelvic organ prolapse (Olafsdottir, 2020)"},"content":{"rendered":"\n

STUDY TITLE: <\/strong>Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 8 genetic variants associated with pelvic organ prolapse.<\/p>\n\n\n\n

OVERVIEW: <\/strong>The muscles that support a woman\u2019s pelvic organs can weaken, causing organs like the bladder and uterus to drop lower in the pelvis<\/em>. This condition is called pelvic organ prolapse, which results in symptoms like pressure in the pelvic area, bowel problems, and sexual dysfunction. It is very common, affecting nearly 1 in 3 women at some point during their lifetime. This genome-wide association study examined over 355,000 females of European ancestry to better understand the genetic risk factors for pelvic organ prolapse. The study identified 8 variants associated with pelvic organ prolapse, which collectively explain an estimated 12% of the heritability of the condition. One of the discovered genetic variants appears to affect the estrogen<\/em> signaling pathway, while another variant influences maintenance of connective tissue in the pelvis<\/em>.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Pelvic organ prolapse is most commonly caused by pregnancy and childbirth. Obesity, old age, and conditions with frequent coughing are also risk factors for developing the condition. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"Sample<\/a><\/figure>\n\n\n\n

ANALYZED VARIANTS:<\/strong> rs3820282 rs9306894 rs1430191 rs3791675 rs7682992 rs72624976 rs1247943 rs12325192<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
Pelvic prolapse<\/a>
Estrogen<\/a> <\/a>
Video<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> March 31, 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank SUMMARY: Identification of 8 genetic variants associated with pelvic organ prolapse. OVERVIEW: The muscles that support a woman\u2019s pelvic organs can weaken, causing …<\/p>\n

Pelvic organ prolapse (Olafsdottir, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":1609,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-1606","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"\nThe 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