{"id":1952,"date":"2020-05-18T20:28:54","date_gmt":"2020-05-19T00:28:54","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=1952"},"modified":"2021-01-27T01:56:03","modified_gmt":"2021-01-27T06:56:03","slug":"genetics-of-lvef-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-of-lvef-pirruccello-2020\/","title":{"rendered":"Left ventricular ejection fraction (Pirruccello, 2020)"},"content":{"rendered":"\n

STUDY TITLE:<\/strong> Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Identification of 22 genetic variants associated with the heart\u2019s left ventricular ejection fraction (LVEF).<\/p>\n\n\n\n

OVERVIEW:<\/strong> The human heart is a muscle that pumps blood throughout the body. It consists of 4 chambers: 2 atria (left and right) and 2 ventricles (left and right). Blood that has been enriched with oxygen in the lungs enters the left atrium and then flows into the left ventricle from where it\u2019s pumped to all other parts of the body. When the left ventricle contracts, not all blood is ejected and some remains inside of the ventricle. Left ventricular ejection fraction (LVEF) is calculated by dividing the blood volume that leaves the left ventricle when the heart muscles contract by the blood volume that remains inside the left ventricle. A normal left ventricular ejection fraction (LVEF) ranges from 55% to 70%. To identify genetic variants associated with LVEF, this genome-wide association study examined over 36,000 individuals of European ancestry. The study identified 22 genetic variants including variants near genes that are responsible for the flexibility of the heart\u2019s muscle (TTN) and genes associated with the immune system. Together these variants explain ~ 31% of LVEF heritability. The study also found that a high polygenic score for LVEF was strongly correlated with the risk of dilated cardiomyopathy. This condition describes a heart muscle that is too stretched thin and cannot pump efficiently.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Stress increases heart rate and blood pressure, both of which can negatively impact the health\u2019s health. Taking steps to control stress through activities such as meditation, exercise, and therapy may be effective in decreasing the risk of various heart conditions. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"Left<\/a><\/figure>\n\n\n\n

LVEF-ASSOCIATED VARIANTS:<\/strong> rs72840788, rs1739837, rs2562845, rs11710541, rs3176326, rs3807309, rs12452367, rs2070458, rs56099248, rs8023658, rs35999985, rs5029142, rs10871753, rs10925197, rs4073554, rs36029352, rs113819537, rs9274626, rs2047273, rs189569984, rs721067, rs2503715<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
The heart (Video)<\/a>
<\/a><\/a>Ejection fraction<\/a><\/p>\n\n\n\n

YOU MAY ALSO BE INTERESTED IN:
<\/strong>Stroke volume (Pirruccello, 2020)<\/a>
Left ventricular end-diastolic volume (Pirruccello, 2020)<\/a>
Left ventricular end-systolic volume (Pirruccello, 2020)<\/a>
Resting heart rate (Eppinga, 2016)<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> May 19, 2020<\/p>\n\n\n\n


<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy SUMMARY: Identification of 22 genetic variants associated with the heart\u2019s left ventricular ejection fraction (LVEF). OVERVIEW: The human heart is a muscle that …<\/p>\n

Left ventricular ejection fraction (Pirruccello, 2020)<\/span> Read More 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