{"id":2017,"date":"2020-06-02T21:15:24","date_gmt":"2020-06-03T01:15:24","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=2017"},"modified":"2021-01-27T01:56:02","modified_gmt":"2021-01-27T06:56:02","slug":"genetics-her2-like-breast-cancer-zhang-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/genetics-her2-like-breast-cancer-zhang-2020\/","title":{"rendered":"HER2-enriched-like breast cancer (Zhang, 2020)"},"content":{"rendered":"\n

STUDY TITLE:<\/strong> Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses<\/a><\/p>\n\n\n\n

SUMMARY:<\/strong> Discovery of novel genetic variants associated with HER2-enriched-like breast cancer.<\/p>\n\n\n\n

OVERVIEW:<\/strong> Breasts are complex structures with multiple cell types which can give rise to multiple types of cancer. Breast cancers are classified by what receptors<\/em> cancer cells have on the outside. This classification is helpful for predicting outcomes and effective treatments. Breast cancers that use the human epidermal growth factor 2 receptor (HER2+) make up 15-30% of all breast cancers. HER2+ breast cancers are historically associated with poor prognosis and an increased recurrence, but there are now new drugs that specifically target the HER2 receptor and improve survival. HER2-enriched-like cancers have the HER2 receptor but do not have other hormone receptors<\/em> like receptors<\/em> for estrogen or progesterone. This genome-wide association study examined nearly 266,000 individuals of European ancestry to identify genetic variants associated with different breast cancer types, including HER2-enriched-like cancers. In total, the researchers identified 330 genomic regions associated with breast cancer types and used them to calculate polygenic scores.<\/p>\n\n\n\n

DID YOU KNOW?<\/strong> Modern therapies are able to specifically target cells that express HER2. This has dramatically increased the survival rate for patients with HER2+ breast cancer. [SOURCE]<\/a><\/p>\n\n\n\n

SAMPLE RESULTS:<\/strong> Learn more about the Nebula Research Library<\/a>. <\/p>\n\n\n\n

\"her2-like<\/a><\/figure>\n\n\n\n

HER2-ENRICHED BREAST CANCER-ASSOCIATED VARIANTS:<\/strong> rs9712235, rs4602255, rs188092014, rs13256025, rs13277568, rs11652463, rs495367, rs7924772, rs78378222, rs206435, rs17215231, rs612683, rs616488, rs7513707, rs12406858, rs637868, rs11249433, rs111458676, rs11205303, rs12091730, rs2992756, rs35383942, rs6686987, rs7514172, rs2785646, rs2576261, rs11118563, rs72755295, rs4233486, rs114282204, rs707475, rs2151842, rs78425380, rs6746250, rs17625845, rs10164550, rs10179592, rs17726078, rs1550622, rs2356656, rs6743383, rs10197246, rs4442975, rs11693806, rs3791977, rs4676356, rs6725517, rs12472404, rs4322799, rs1036759, rs9882792, rs552647, rs112476261, rs17838698, rs56387622, rs6762558, rs2886671, rs9825432, rs13066793, rs639355, rs62331150, rs56039025, rs13147907, rs10012017, rs17014016, rs17157372, rs335160, rs1428387, rs10069690, rs6860806, rs62329727, rs1432679, rs17611291, rs10074269, rs6864691, rs4868701, rs116095464, rs187108781, rs4613718, rs10941679, rs17343002, rs889310, rs16886165, rs76250845, rs11949391, rs113778879, rs3010266, rs157557, rs418053, rs2121348, rs6913578, rs60954078, rs851984, rs6904031, rs910416, rs3819405, rs9364472, rs6940159, rs12211970, rs9358466, rs34196306, rs111342015, rs73754909, rs71559437, rs7800548, rs12706954, rs68056147, rs62485509, rs7971, rs289997, rs74765302, rs13244925, rs17268829, rs4439053, rs111963714, rs62517052, rs12546444, rs13267382, rs62526620, rs35542655, rs12541094, rs7842619, rs12550713, rs10096351, rs1016578, rs7830152, rs66823261, rs1028016, rs310295, rs9693444, rs13365225, rs1511243, rs72658084, rs1533366, rs10816625, rs13294895, rs7848334, rs630965, rs1895062, rs3861871, rs17694493, rs4880038, rs10975870, rs10120432, rs10885405, rs12250948, rs45631580, rs45631563, rs10796139, rs7072776, rs10764337, rs2384736, rs10995201, rs6479868, rs111833376, rs719338, rs4980029, rs7125780, rs610437, rs625145, rs7121616, rs7939702, rs11822830, rs10832963, rs4980386, rs4472923, rs7394715, rs10838267, rs77047825, rs12287832, rs10896047, rs35039974, rs661204, rs78540526, rs6597981, rs2454399, rs12422552, rs788458, rs7297051, rs2277339, rs17356907, rs56404467, rs11571833, rs9315973, rs12870942, rs2181965, rs4983544, rs34914085, rs2253012, rs2588809, rs11624333, rs941764, rs78440108, rs144767203, rs187010898, rs4774565, rs8042593, rs35874463, rs8035987, rs2290202, rs34872983, rs75753503, rs11076805, rs35668161, rs4784227, rs55872725, rs6499648, rs7184573, rs28539243, rs12709163, rs7500067, rs9931038, rs12449271, rs79461387, rs150537328, rs11296, rs17881320, rs149370081, rs2787486, rs745570, rs16976596, rs11665269, rs1111207, rs527616, rs8092192, rs72931898, rs9954058, rs9952980, rs117922601, rs56069439, rs10164323, rs56681946, rs4399645, rs1172821, rs1154723, rs6030585, rs13039563, rs16991615, rs2822999, rs2823130, rs2403907, rs4818836, rs9798754, rs17879961, rs5997390, rs34134147, rs132289, rs5750715, rs9611990, rs112855987, rs28512361<\/p>\n\n\n\n

ADDITIONAL RESOURCES:<\/strong>
HER2 positive breast cancer: everything you must know (Video)<\/a>
HER2 status<\/a><\/p>\n\n\n\n

YOU MAY ALSO BE INTERESTED IN:
<\/strong>Luminal A-like breast cancer (Zhang, 2020)<\/a>
Luminal B\/HER2-negative-like breast cancer (Zhang, 2020)<\/a>
Luminal B-like breast cancer (Zhang, 2020)<\/a>
Triple-negative breast cancer (Zhang, 2020)<\/a>
Breast cancer (Shu, 2020)<\/a><\/p>\n\n\n\n

WEEKLY UPDATE:<\/strong> June 2, 2020<\/p>\n\n\n\n


<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses SUMMARY: Discovery of novel genetic variants associated with HER2-enriched-like breast cancer. OVERVIEW: Breasts are complex structures with multiple cell types which can give …<\/p>\n

HER2-enriched-like breast cancer (Zhang, 2020)<\/span> Read More 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