{"id":44161,"date":"2023-10-17T09:38:12","date_gmt":"2023-10-17T13:38:12","guid":{"rendered":"https:\/\/nebula.org\/blog\/?p=44161"},"modified":"2024-05-07T14:34:24","modified_gmt":"2024-05-07T18:34:24","slug":"is-fibromuscular-dysplasia-genetic","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/is-fibromuscular-dysplasia-genetic\/","title":{"rendered":"Fibromuscular Dysplasia &#8211; Is Fibromuscular Dysplasia Genetic?"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-nebula-genomics-dna-report-for-fibromuscular-dysplasia\"><strong>Nebula Genomics DNA Report for Fibromuscular Dysplasia<\/strong><\/h2>\n\n\n\n<p>Is fibromuscular dysplasia genetic? We created a DNA report based on a study that attempted to answer this question. Below you can see a SAMPLE DNA report. To get your personalized DNA report, purchase our <a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">Whole Genome Sequencing<\/a>!<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2024\/05\/Screenshot-2024-05-07-at-2.30.10\u202fPM.png\" alt=\"\" class=\"wp-image-45678\" style=\"width:800px\" width=\"800\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2024\/05\/Screenshot-2024-05-07-at-2.30.10\u202fPM.png 886w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2024\/05\/Screenshot-2024-05-07-at-2.30.10\u202fPM-300x173.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2024\/05\/Screenshot-2024-05-07-at-2.30.10\u202fPM-768x444.png 768w\" sizes=\"(max-width: 886px) 100vw, 886px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-1 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-vivid-cyan-blue-background-color has-background wp-element-button\" href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><strong>Sequence your genome and access over 200 DNA reports!<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-yoast-seo-table-of-contents yoast-table-of-contents\"><h2>Table of contents<\/h2><ul><li><a href=\"#h-nebula-genomics-dna-report-for-fibromuscular-dysplasia\" data-level=\"2\">Nebula Genomics DNA Report for Fibromuscular Dysplasia<\/a><\/li><li><a href=\"#h-what-is-fibromuscular-dysplasia\" data-level=\"2\">What is Fibromuscular dysplasia?<\/a><ul><li><a href=\"#h-types\" data-level=\"3\">Types<\/a><\/li><\/ul><\/li><li><a href=\"#h-is-fibromuscular-dysplasia-genetic\" data-level=\"2\">Is Fibromuscular Dysplasia Genetic?<\/a><\/li><li><a href=\"#h-epidemiology\" data-level=\"2\">Epidemiology<\/a><\/li><li><a href=\"#h-symptoms\" data-level=\"2\">Symptoms<\/a><\/li><li><a href=\"#h-causes\" data-level=\"2\">Causes<\/a><\/li><li><a href=\"#h-diagnosis\" data-level=\"2\">Diagnosis<\/a><\/li><li><a href=\"#h-treatment\" data-level=\"2\">Treatment<\/a><\/li><\/ul><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-fibromuscular-dysplasia\"><strong>What is Fibromuscular dysplasia?<\/strong><\/h2>\n\n\n\n<p>Fibromuscular dysplasia (FMD) is a rare systemic vascular disease affecting the arteries. This coronary artery disease causes abnormal growths or deformities in artery walls. This effect can lead to stiffening, narrowing (stenosis), or enlargement (aneurysm) of the affected blood vessels. If an artery is too stiff it will be unable to function when blood runs through it, which could lead to high blood pressure. On the other hand, if it is too weak, it can dilate and lead to an artery aneurysm.&nbsp;<\/p>\n\n\n\n<p>Fibromuscular dysplasia <a href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/circulationaha.111.090449\" target=\"_blank\" rel=\"noreferrer noopener\">can affect any artery<\/a> in the body. Most commonly, it affects those leading to the kidneys and brain. However, artery involvement may also affect the neck, abdomen, and legs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-types\">Types<\/h3>\n\n\n\n<p>There are two types of FMD: Multifocal and focal. The former is more common and causes affected arteries to look like a string of beads with a repeated pattern of narrowing and bulging. This form represents areas that are too stiff and too week. Focal fibromuscular dysplasia is less common and involves abnormal area of tissue on the artery wall.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" width=\"916\" height=\"504\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/Fibromuscular-dysplasia-presentation.jpg\" alt=\"Multifocal fibromuscular dysplasia\" class=\"wp-image-44178\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/Fibromuscular-dysplasia-presentation.jpg 916w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/Fibromuscular-dysplasia-presentation-300x165.jpg 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/Fibromuscular-dysplasia-presentation-768x423.jpg 768w\" sizes=\"(max-width: 916px) 100vw, 916px\" \/><figcaption class=\"wp-element-caption\">Multifocal fibromuscular dysplasia. <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Fibr.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">Wikipedia<\/a>. Pierre-Fran\u00e7ois Plouin, J\u00e9r\u00f4me Perdu, Agn\u00e8s La Batide-Alanore, Pierre Boutouyrie, Anne-Paule Gimenez-Roqueplo, Xavier Jeunemaitre. Fibromuscular dysplasia. Orphanet Journal of Rare Diseases. 2, 28. 2007. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17555581?dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">PMID 17555581<\/a>. (<a href=\"http:\/\/www.ojrd.com\/content\/2\/1\/28\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.ojrd.com\/content\/2\/1\/28<\/a>). CC-<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" target=\"_blank\" rel=\"noreferrer noopener\">Attribution 2.0 Generic<\/a>.<\/figcaption><\/figure>\n\n\n\n<p>The exact cause of fibromuscular dysplasia is unknown, but it is believed to be a combination of genetic and environmental factors. It can occur at any age, but is more common in women around 50. Symptoms can vary depending on the affected artery. Complications include <a href=\"https:\/\/nebula.org\/blog\/is-high-blood-pressure-genetic\/\">high blood pressure<\/a>, headaches, dizziness, ringing in the ears, vision changes, abdominal pain, and leg pain.<\/p>\n\n\n\n<p>A doctor may use a physical exam or imaging tests such as an ultrasound, CT scan, MRI, or biopsy to diagnose the condition. There is no cure for fibromuscular dysplasia, but treatment options aim to manage symptoms and prevent complications. Treatment may include medications to control blood pressure or manage pain, procedures to widen or bypass the affected arteries, or surgery in severe cases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-is-fibromuscular-dysplasia-genetic\"><strong>Is Fibromuscular Dysplasia Genetic?<\/strong><\/h2>\n\n\n\n<p>Several studies suggest a genetic basis for FMD, as it can run in families. Additionally, specific genetic mutations have been associated with the condition. However, the inheritance pattern is unclear, as it can occur <a href=\"https:\/\/academic.oup.com\/cardiovascres\/article\/118\/1\/65\/6178787\" target=\"_blank\" rel=\"noreferrer noopener\">sporadically or be inherited<\/a> in an autosomal dominant or autosomal recessive pattern depending on the underlying genetic mutation. It is important to note that not all cases of fibromuscular dysplasia have a clear genetic basis. Other factors, such as hormonal changes and smoking, have also been linked to its development.<\/p>\n\n\n\n<p>Olin JW et al published one of the most <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.cir.0000442577.96802.8c\" target=\"_blank\" rel=\"noreferrer noopener\">comprehensive reports<\/a> on the science of the condition in 2014.&nbsp;<\/p>\n\n\n\n<p>In 2020, a paper published in <em>Hypertension<\/em> sought to <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/HYPERTENSIONAHA.120.14793\" target=\"_blank\" rel=\"noreferrer noopener\">link the <em>PHACTR1<\/em> gene with FM<\/a>D. While the authors did find an association, their study was limited by the small cohort and lack of significance after multiple testing corrections.<\/p>\n\n\n\n<p>Authors of a 2021 paper published in <em>Nature Communications <\/em>reported the first genome-wide association meta-analysis of six studies to identify <a href=\"https:\/\/www.nature.com\/articles\/s41467-021-26174-2\" target=\"_blank\" rel=\"noreferrer noopener\">five genome wide significant loci potentially involved<\/a> in the genetic cause of fibromuscular dysplasia. The genome-wide association study pinpointed locations previously been associated with multiple vascular disorders. The genes include <em>PHACTR1<\/em>, <em>LRP1<\/em>, <em>ATP2B1<\/em>, <em>LIMA1<\/em>, and <em>SLC24A3<\/em>. The risk genes for FMD were usually expressed in smooth muscle cells, fibroblasts, and arterial tissues.<\/p>\n\n\n\n<p>You can read more about this paper in <a href=\"https:\/\/www.michiganmedicine.org\/health-lab\/new-genes-identified-fibromuscular-dysplasia\" target=\"_blank\" rel=\"noreferrer noopener\">this commentary<\/a>, with voices by the University of Michigan Health Frankel Cardiovascular Center.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-epidemiology\"><strong>Epidemiology<\/strong><\/h2>\n\n\n\n<p>Experts do not entirely understand disease prevalence due to its rarity and the lack of symptoms in many people. Studies based in the United States estimate it affects <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0147956320303915\" target=\"_blank\" rel=\"noreferrer noopener\">12 out of 100,000 individuals<\/a>, with a much higher prevalence in women than men. Doctors typically diagnose FMD cases in middle-aged individuals, with a peak incidence when people are in their 50s and 60s. It can also affect younger women and accounts for <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK493204\/#:~:text=Fibromuscular%20dysplasia%20(FMD)%20is%20a,can%20affect%20any%20arterial%20bed.\" target=\"_blank\" rel=\"noreferrer noopener\">10% to 20% of the cases<\/a> of renal artery stenosis.<\/p>\n\n\n\n<p>Fibromuscular dysplasia can occur sporadically or familial, with a reported prevalence of up to <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK493204\/#:~:text=Fibromuscular%20dysplasia%20(FMD)%20is%20a,can%20affect%20any%20arterial%20bed.\" target=\"_blank\" rel=\"noreferrer noopener\">20% in first-degree relatives<\/a> of affected individuals. Familial FMD is most commonly inherited in an autosomal dominant pattern, but other ways of inheritance have also been described. Fibromuscular dysplasia is also more common among people with certain connective tissue disorders (e.g., Ehlers-Danlos syndrome).<\/p>\n\n\n\n<p>The paper above also cites the prevalence of renal FMD as 0.4 %, whereas craniocervical fibromuscular dysplasia is much lower at 0.1%. Among older hypertensive FMD patients who underwent renal angiography, scientists saw a prevalence of 5.8%.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-symptoms\"><strong>Symptoms<\/strong><\/h2>\n\n\n\n<p>Fibromuscular dysplasia is a cardiovascular disease that causes narrowing and enlargement of medium-sized arteries. The symptoms may vary depending on the location and severity of the disease.&nbsp;<\/p>\n\n\n\n<p>Some individuals with fibromuscular dysplasia may not experience clinical manifestations, while others may develop serious complications.&nbsp;<\/p>\n\n\n\n<p>The two most common symptoms for those who experience fibromuscular dysplasia of the renal arteries are high blood pressure (hypertension) and poor kidney function. Many patients with FMD will have renovascular hypertension, a renal arterial disease.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/high-blood-pressure.png\" alt=\"Illustration of high blood pressure\" class=\"wp-image-44186\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/high-blood-pressure.png 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/high-blood-pressure-300x225.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/high-blood-pressure-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">High blood pressure. <a href=\"https:\/\/en.wikiversity.org\/wiki\/WikiJournal_of_Medicine\/Medical_gallery_of_Blausen_Medical_2014\" target=\"_blank\" rel=\"noreferrer noopener\">Blausen.com staff (2014)<\/a>. &#8220;Medical gallery of Blausen Medical 2014&#8221;. WikiJournal of Medicine 1 (2). <a href=\"https:\/\/en.wikipedia.org\/wiki\/Digital_object_identifier\">DOI<\/a>:<a href=\"https:\/\/doi.org\/10.15347\/wjm\/2014.010\" target=\"_blank\" rel=\"noreferrer noopener\">10.15347\/wjm\/2014.010<\/a>. <a href=\"https:\/\/en.wikipedia.org\/wiki\/International_Standard_Serial_Number\">ISSN<\/a> <a href=\"https:\/\/www.worldcat.org\/issn\/2002-4436\" target=\"_blank\" rel=\"noreferrer noopener\">2002-4436<\/a>. CC-<a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\" target=\"_blank\" rel=\"noreferrer noopener\">Attribution 3.0 Unported<\/a>. <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Blausen_0092_BloodPressureFlow.png\">Wikipedia<\/a>.<\/figcaption><\/figure>\n\n\n\n<p>If the condition affects the carotid and vertebral arteries leading to the brain and neck, patients with the carotid artery version most likely experience <a href=\"https:\/\/nebula.org\/blog\/are-migraines-genetic\/\">migraine headaches<\/a>, tinnitus, dizziness or <a href=\"https:\/\/nebula.org\/blog\/is-vertigo-genetic\/\">vertigo<\/a>, and neck pain.&nbsp;When serious, fibromuscular dysplasia can cause serious complications such as aneurysm ruptures, spontaneous coronary arterial dissection (SCAD), <a href=\"https:\/\/nebula.org\/blog\/are-strokes-genetic\/\">stroke<\/a>, or a transient ischemic attack (TIA or mini-stroke). Stroke in fibromuscular dysplasia is associated with cervical artery dissection, which occurs when there is a tear in a carotid or vertebral artery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-causes\"><strong>Causes<\/strong><\/h2>\n\n\n\n<p>The exact cause of fibromuscular dysplasia is poorly understood, but it is believed to be a complex interplay of genetic and environmental factors.<\/p>\n\n\n\n<p>Some genetic factors that experts believe may be associated with FMD include mutations in genes that code for proteins involved in the structural integrity of arterial walls. These mutations can cause abnormal development of arterial walls, leading to the characteristic fibrous and muscular tissue changes seen in fibromuscular dysplasia. Although research is still being conducted, experts have observed that some cases may run in families.<\/p>\n\n\n\n<p>Consistent with the observation that females are at greater risk, doctor believe that sex-specific hormones are risk factors for the disease development. Variables related to pregnancy do not appear to increase risk.<\/p>\n\n\n\n<p>Environmental factors, such as smoking, may also play a role. When patients are diagnosed with the condition, smoking may make it worse.<\/p>\n\n\n\n<p>Fibromuscular dysplasia can also occur as part of other underlying medical conditions, such as neurofibromatosis type 1 and Alport syndrome, but these cases are relatively rare.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-diagnosis\"><strong>Diagnosis<\/strong><\/h2>\n\n\n\n<p>Diagnosis of FMD can be challenging, as the symptoms may be nonspecific or may not appear until the disease has progressed. Doctors often detect it incidentally during imaging studies performed for other conditions. Sometimes, a patient will only learn of it after suffering a life-threatening event like an aneurysm.<\/p>\n\n\n\n<p>A doctor may start with ordering blood tests for related conditions, such as atherosclerosis, that can narrow arteries.&nbsp;<\/p>\n\n\n\n<p>To diagnose fibromuscular dysplasia, the doctor will usually perform a physical exam, review the patient&#8217;s medical history, and order imaging tests to evaluate the arterial structure and blood flow. These tests may include ultrasound, magnetic resonance angiography, and computed tomography angiography.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" width=\"974\" height=\"674\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/CT-scan-of-fibromuscular-dysplasia.jpg\" alt=\"CT scan of fibromuscular dysplasia\" class=\"wp-image-44194\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/CT-scan-of-fibromuscular-dysplasia.jpg 974w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/CT-scan-of-fibromuscular-dysplasia-300x208.jpg 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2023\/10\/CT-scan-of-fibromuscular-dysplasia-768x531.jpg 768w\" sizes=\"(max-width: 974px) 100vw, 974px\" \/><figcaption class=\"wp-element-caption\">CT scan of fibromuscular dysplasia. <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:CTA_FMD.jpg\" target=\"_blank\" rel=\"noreferrer noopener\">Wikipedia<\/a>. Pierre-Fran\u00e7ois Plouin, J\u00e9r\u00f4me Perdu, Agn\u00e8s La Batide-Alanore, Pierre Boutouyrie, Anne-Paule Gimenez-Roqueplo, Xavier Jeunemaitre. Fibromuscular dysplasia. Orphanet Journal of Rare Diseases. 2, 28. 2007. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17555581?dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">PMID 17555581<\/a>. (<a href=\"http:\/\/www.ojrd.com\/content\/2\/1\/28\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.ojrd.com\/content\/2\/1\/28<\/a>). CC-<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\/deed.en\" target=\"_blank\" rel=\"noreferrer noopener\">Attribution 2.0 Generic<\/a>.<\/figcaption><\/figure>\n\n\n\n<p>The healthcare provider may also order additional tests to evaluate the function of the affected organ, such as a renal function test or cardiac stress test.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-treatment\"><strong>Treatment<\/strong><\/h2>\n\n\n\n<p>While there is no cure for the condition, treatments can manage the symptoms and prevent complications. Fibromuscular dysplasia treatment depends on the location and severity of the disease, as well as the presence of any complications or symptoms.<\/p>\n\n\n\n<p><strong>Antiplatelet or anticoagulant therapy:<\/strong> These medications thin the blood, which can reduce the risk of blood clots or stroke.<\/p>\n\n\n\n<p><strong>Blood pressure control: <\/strong>If the condition causes high blood pressure, the first line of treatment is often medications to lower blood pressure, such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or calcium channel blockers.<\/p>\n\n\n\n<p><strong>Angioplasty and stenting:<\/strong> In some cases, balloon angioplasty (a procedure that uses a balloon to widen the narrowed artery) and stenting (placing a small mesh tube to keep the route open) may be performed to restore blood flow in the affected artery.<\/p>\n\n\n\n<p><strong>Surgery:<\/strong> In severe cases or when other treatments are ineffective, doctors may use surgery to repair or bypass the affected artery.<\/p>\n\n\n\n<p>It is important to note that FMD is a chronic condition, and lifelong monitoring and management are often necessary. Doctors often recommend annual imaging studies and lifestyle changes such as quitting smoking, reducing salt, and daily exercise.<\/p>\n\n\n\n<p>If you liked this article, you should check out our other posts in the <a href=\"https:\/\/nebula.org\/blog\/nebula-library-unlocking-genetic-research\/\">Nebula Research Library<\/a>!<\/p>\n\n\n\n<p class=\"has-medium-font-size\">October 17, 2023<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nebula Genomics DNA Report for Fibromuscular Dysplasia Is fibromuscular dysplasia genetic? We created a DNA report based on a study that attempted to answer this question. Below you can see a SAMPLE DNA report. To get your personalized DNA report, &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/is-fibromuscular-dysplasia-genetic\/\"> <span class=\"screen-reader-text\">Fibromuscular Dysplasia &#8211; Is Fibromuscular Dysplasia Genetic?<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":18,"featured_media":44203,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"Photo by Robina Weermeijer on Unsplash\n  ","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[50],"tags":[],"class_list":["post-44161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.13 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Is fibromuscular dysplasia genetic? | Decode DNA and learn risks!<\/title>\n<meta name=\"description\" content=\"Is fibromuscular dysplasia genetic? 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