{"id":541,"date":"2019-02-28T02:36:38","date_gmt":"2019-02-28T02:36:38","guid":{"rendered":"http:\/\/nebula.org\/blog\/?p=541"},"modified":"2021-01-29T15:19:47","modified_gmt":"2021-01-29T20:19:47","slug":"george-church-podcast","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/george-church-podcast\/","title":{"rendered":"Podcast: What&#8217;s in the Water at the George Church Lab?"},"content":{"rendered":"\n<p><em>Edited by Christina Swords, Ph.D.<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/a16z.com\/author\/jorge-conde\/\">Jorge Conde<\/a> (JC) of<a href=\"https:\/\/a16z.com\/2019\/02\/26\/george-church-lab-genome-sequencing-crispr\/\"> Andreessen Horowitz (a16z)<\/a> recently spoke with Nebula Genomics co-founder, George Church (GC). When Jorge and George discuss diagnosis and prevention of disease [14:15] and the reasons why the number of people that have had their whole genome sequenced is still very low [19:35], it reminds us of our mission at Nebula and what we work on every day.<\/p>\n\n\n\n<figure><iframe width=\"100%\" height=\"166\" src=\"https:\/\/w.soundcloud.com\/player\/?url=https%3A\/\/api.soundcloud.com\/tracks\/581831640&amp;color=%23ff5500&amp;auto_play=false&amp;hide_related=false&amp;show_comments=true&amp;show_user=true&amp;show_reposts=false&amp;show_teaser=true\"><\/iframe><\/figure>\n\n\n\n<p>14:15 &#8211; Diagnosis and prevention of disease using whole genome sequencing.<br><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>JC: &#8220;What do you see as the next non-incremental step function change in the way we treat diseases, or manage diseases, or even diagnose diseases?&#8221;<br><\/p><p>GC: &#8220;Well first of all, if we started diagnosing that would be a really big thing. As a population, even worldwide, we&#8217;re under-diagnosed. There are a lot of VERY cost effective diagnoses [&#8230;] and the care providers are not compensated as much [for them] as [for] some less effective, but expensive medicine. So diagnosis would be terrific.&#8221;<br><\/p><p>JC: &#8220;So basically, you&#8217;re saying misaligned incentives and human behavior have mitigated how much prevention we actually do?&#8221;<br><\/p><p>GC: &#8220;That&#8217;s right. But [personal genetics] would be a huge breakthrough so we could do more diagnosis and more prevention. Now, the ultimate diagnosis for genetics is whole genome sequencing [&#8230;].&#8221;<br><\/p><\/blockquote>\n\n\n\n<p>19:35 &#8211; Three reasons why [mass adoption of whole genome sequencing] hasn&#8217;t happened yet?<br><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>GC on costs of sequencing: &#8220;Cost should probably be zero dollars.&#8221;<br><\/p><p>GC on genomic data privacy: &#8220;We should have a convincing mechanism of people getting benefit from their genome without [&#8230;] anybody else knowing their genome. We should have something where [it can be used in an] encrypted form, not available to anybody, including insurance and government.&#8221;<br><\/p><p>GC on the value of genomic data: &#8220;Most people don\u2019t understand the value [of personal genomic data]. It&#8217;s either misrepresented, but by both extremes. Some people say it&#8217;s so valuable that you&#8217;re going to whip out your cell phone twice a day and some people say I can&#8217;t imagine ever using it. And the reality is somewhere in between [&#8230;].&#8221;<br><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Edited by Christina Swords, Ph.D. Jorge Conde (JC) of Andreessen Horowitz (a16z) recently spoke with Nebula Genomics co-founder, George Church (GC). When Jorge and George discuss diagnosis and prevention of disease [14:15] and the reasons why the number of people &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/george-church-podcast\/\"> <span class=\"screen-reader-text\">Podcast: What&#8217;s in the Water at the George Church Lab?<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":18,"featured_media":560,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[2350],"tags":[],"class_list":["post-541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.13 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What&#039;s in the Water at the George Church Lab? 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