Nebula Library
Library Publications
Title:
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Summary:
Identification of genetic variants associated with anorexia nervosa are also linked to a low body-mass index.
Read more: Anorexia Nervosa (Watson, 2019)
on our Blog
Title:
Common genetic variants influence human subcortical brain structures
Summary:
This study identified novel genetic variants that may influence the subcortical brain structures which are involved in complex activities including movement, emotions, and learning.
Title:
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Summary:
This study identified hundreds of new genetic variants associated with risky behavior in genes, most of which are highly expressed in the brain.
Read more: Risky Behavior (Linnér, 2019)
on our Blog
Title:
Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts
Summary:
Genetic variants near the TGFB2 gene may increase the risk of emphysema by elevating TGFB2 expression in lung fibroblasts.
Read more: Emphysema (Parker, 2019)
on our Blog
Title:
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Summary:
Genetic variants in genes expressed in the brain are associated with major depressive disorder.
Read more: Depression (Wray, 2018)
on our Blog
Title:
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
Summary:
This study identified novel genetic variants associated with non-alcoholic fatty liver disease (NAFLD).
Read more: July 2019 – NAFLD
on our Blog
Title:
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
Summary:
This study identified eight new loci associated with re-experiencing post-traumatic stress disorder (PTSD) trauma.
Read more: PTSD (Gelernter, 2019)
on our Blog
Title:
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Summary:
Discovery of 46 new loci associated with alcohol consumption and links to neuropsychiatric disorders like schizophrenia.
Title:
Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Summary:
Newly identified genetic variants in genes that regulate cell development and cell death are associated with higher intelligence.
Read more: Intelligence (Sniekers, 2017)
on our Blog
Title:
Discovery of common and rare genetic risk variants for colorectal cancer
Summary:
Genetic variants in genes involved in transcription, cell signaling, and the immune system are associated with the risk of colorectal cancer.
Read more: Colorectal Cancer (Huyghe, 2018)
on our Blog
Title:
Genome-wide association analysis of 350,000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema
Summary:
This study discovered 41 new genetic variants that are associated with asthma, hay fever, eczema or a combination of the three.
Read more: Asthma (Johansson, 2019)
on our Blog
Title:
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
Summary:
Identification of novel genetic variants associated with personality traits as well as a genetic correlation between personality and predisposition to psychiatric disorders.
Read more: Personality (Lo, 2017)
on our Blog
Title:
Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder
Summary:
12 novel loci have been associated with ADHD in a genome-wide association study of 55,374 individuals.
Title:
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Summary:
Identification of six new genetic variants associated with LDL and HDL cholesterol as well as triglyceride levels in the blood.
Title:
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Summary:
Identification of genetic variants that influence the risk of Alzheimer’s disease.
Title:
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Summary:
Identification of 42 novel genetic variants related to excessive daytime sleepiness and other sleep-related disorders.
Read more: Daytime Sleepiness (Wang, 2019)
on our Blog
Title:
A meta-analysis of genome-wide association studies identifies multiple longevity genes
Summary:
Identification of multiple genetic variants associated with human longevity.
Read more: Longevity (Deelen, 2019)
on our Blog
Title:
Genomic and Transcriptomic Association Studies Identify 16 Novel Susceptibility Loci for Venous Thromboembolism
Summary:
Identification of novel genetic variants associated with blood traits and venous thromboembolism risk.
Title:
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Summary:
Genetic variants linked to inflammation and programmed cell death may affect the risk for ulcerative colitis.
Title:
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
Summary:
A genetic variant on chromosome 6 may be linked to dilated cardiomyopathy.
Read more: Cardiomyopathy (Warren, 2017)
on our Blog
Title:
Genome-wide association study of cerebral small vessel disease reveals established and novel loci
Summary:
Identification of novel genetic variants linked to cerebral small vessel disease, which can cause a variety of cognitive symptoms.
Title:
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risks
Summary:
Identification of 32 novel genetic variants associated with high blood pressure.
Read more: Blood Pressure (Warren, 2019)
on our Blog
Title:
Genome-wide meta-analysis identifies new susceptibility loci for migraine
Summary:
Identification of genetic variants associated with migraines and synaptic function.
Read more: Migraine (Anttila, 2013)
on our Blog
Title:
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Summary:
Identification of novel genetic variants associated with same-sex sexual behavior.
Title:
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk variants
Summary:
Identification of 7 novel genetic variants that may confer an increased risk of developing rheumatoid arthritis.
Title:
Identification of common genetic risk variants for autism spectrum disorder
Summary:
Identification of novel genetic variants linked to autism spectrum disorder.
Title:
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
Summary:
A study of over 1 million participants identified 82 novel genetic variants associated with chronic kidney disease.
Title:
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
Summary:
Identification of a novel genetic variant that is associated with prolonged gestational duration (pregnancy).
Read more: Gestational Duration (Liu, 2019)
on our Blog
Title:
Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics
Summary:
Identification of 4 novel genetic variants correlated with handedness.
Read more: Handedness (Wiberg, 2009)
on our Blog
Title:
Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease
Summary:
Identification of over 100 novel genetic variants correlated with fat build-up around the body’s internal organs.
Title:
GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Summary:
Identification of 4 novel genetic variants that correlate with childhood growth and BMI.
Title:
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
Summary:
Genome-wide identification of 68 variants associated with albuminuria, a key indicator of chronic kidney disease.
Read more: Albuminuria (Teumer, 2019)
on our Blog
Title:
Phenome-wide investigation of health outcomes associated with genetic score to loneliness
Summary:
Detection of 19 genetic variants associated with feelings of loneliness.
Read more: Loneliness (Abdellaoui, 2019)
on our Blog
Title:
Phenome-wide investigation of health outcomes associated with genetic score to loneliness
Summary:
Detection of 19 genetic variants associated with feelings of loneliness.
Read more: Loneliness (Abdellaoui, 2019)
on our Blog
Title:
Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse
Summary:
Genome-wide analysis reveals a novel genetic loci correlated with syncope, or fainting.
Read more: Fainting (Hadji-Turdeghal, 2019)
on our Blog
Title:
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
Summary:
Identification of 25 genetic loci that are associated with an increased risk of gastroesophageal reflux disease.
Title:
A genome-wide investigation of food addiction
Summary:
Identification of 2 genetic loci correlated with the development of food addiction.
Title:
Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits
Summary:
Identification of 4 genetic variants associated with psychotic experiences.
Read more: Psychosis (Legge, 2019)
on our Blog
Title:
GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank
Summary:
Identification of 44 genetic variants associated with age-related hearing impairment.
Read more: Hearing Loss (Wells, 2019)
on our Blog
Title:
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Summary:
Identification of 233 novel variants associated with multiple sclerosis and the body’s immune response system.
Read more: Multiple Sclerosis (IMSGC, 2019)
on our Blog
Title:
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Summary:
Identification of 147 novel genetic variants associated with gout development.
Read more: Gout (Tin, 2019)
on our Blog
Title:
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Summary:
Discovery of novel genetic variants associated with an increased risk of chronic lymphocytic leukemia.
Title:
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Summary:
Identification of 5 novel genetic loci correlated to a person’s risk of developing late-onset Alzheimer’s disease.
Title:
Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways
Summary:
Identification of 2 novel genetic variants associated with an increased risk of developing diffuse large B-cell lymphoma.
Title:
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma
Summary:
Identification of over 24 genetic variants that correlate with the development of glaucoma.
Read more: Glaucoma (MacGregor, 2018)
on our Blog
Title:
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Summary:
Identification of 46 genetic variants associated with mosaic loss of chromosome Y.
Title:
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
Summary:
Identification of 116 genetic variants associated with neuroticism.
Read more: Neuroticism (Luciano, 2017)
on our Blog
Title:
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma
Summary:
Identification of over 24 genetic variants that correlate with the development of glaucoma.
Read more: Glaucoma (MacGregor, 2018)
on our Blog
Title:
Genome-wide associations for birth weight and correlations with adult disease
Summary:
Identification of 60 novel genetic variants associated with birth weight and correlated with later-life disease susceptibility.
Title:
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Summary:
Discovery of 41 genetic risk variants associated with allergic rhinitis.
Read more: Allergic Rhinitis (Waage, 2018)
on our Blog
Title:
Multivariate genome-wide analyses of the well-being spectrum
Summary:
Novel method for multivariate traits identifies 304 genetic variants associated with well-being.
Read more: Well-Being (Baselmans, 2019)
on our Blog
Title:
Genetic architecture of subcortical brain structures in 38,851 individuals
Summary:
Identification of 48 genetic loci, including 40 novel loci, associated with the brain’s subcortical volume.
Title:
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits
Summary:
Identification of 23 genetic variants associated with total brain volume.
Read more: Total Brain Volume (Zhao, 2019)
on our Blog
Title:
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
Summary:
Discovery of 13 novel genetic variants associated with the development of systemic sclerosis.
Title:
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease
Summary:
Identification of 22 new genetic variants associated with venous thromboembolism.
Title:
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
Summary:
Identification of 2 novel genetic variants associated with aortic calcification.
Title:
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Summary:
Discovery of 16 novel risk loci for age-related macular degeneration.
Title:
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Summary:
Identification of 3 genetic variants associated with Brugada syndrome, a rare heart disorder.
Read more: Brugada Syndrome (Bezzina, 2013)
on our Blog
Title:
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Summary:
Identification of 58 genetic variants associated with the blood levels of C-reactive protein, a marker of inflammation.
Title:
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
Summary:
Identification of 116 genetic variants associated with neuroticism.
Read more: Neuroticism (Luciano, 2017)
on our Blog
