Nebula Library

Library Publications
Title: Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Summary: Identification of genetic variants associated with anorexia nervosa are also linked to a low body-mass index.
Title: Common genetic variants influence human subcortical brain structures
Summary: This study identified novel genetic variants that may influence the subcortical brain structures which are involved in complex activities including movement, emotions, and learning.
Title: Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Summary: This study identified hundreds of new genetic variants associated with risky behavior in genes, most of which are highly expressed in the brain.
Title: Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts
Summary: Genetic variants near the TGFB2 gene may increase the risk of emphysema by elevating TGFB2 expression in lung fibroblasts.
Title: Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Summary: Genetic variants in genes expressed in the brain are associated with major depressive disorder.
Title: GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
Summary: This study identified novel genetic variants associated with non-alcoholic fatty liver disease (NAFLD).
Title: Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans
Summary: This study identified eight new loci associated with re-experiencing post-traumatic stress disorder (PTSD) trauma.
Title: New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Summary: Discovery of 46 new loci associated with alcohol consumption and links to neuropsychiatric disorders like schizophrenia.
Title: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Summary: Newly identified genetic variants in genes that regulate cell development and cell death are associated with higher intelligence.
Title: Discovery of common and rare genetic risk variants for colorectal cancer
Summary: Genetic variants in genes involved in transcription, cell signaling, and the immune system are associated with the risk of colorectal cancer.
Title: Genome-wide association analysis of 350,000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema
Summary: This study discovered 41 new genetic variants that are associated with asthma, hay fever, eczema or a combination of the three.
Title: Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders
Summary: Identification of novel genetic variants associated with personality traits as well as a genetic correlation between personality and predisposition to psychiatric disorders.
Title: Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder
Summary: 12 novel loci have been associated with ADHD in a genome-wide association study of 55,374 individuals.
Title: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Summary: Identification of six new genetic variants associated with LDL and HDL cholesterol as well as triglyceride levels in the blood.
Title: The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Summary: Identification of genetic variants that influence the risk of Alzheimer’s disease.
Title: Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Summary: Identification of 42 novel genetic variants related to excessive daytime sleepiness and other sleep-related disorders.
Title: A meta-analysis of genome-wide association studies identifies multiple longevity genes
Summary: Identification of multiple genetic variants associated with human longevity.
Title: Genomic and Transcriptomic Association Studies Identify 16 Novel Susceptibility Loci for Venous Thromboembolism
Summary: Identification of novel genetic variants associated with blood traits and venous thromboembolism risk.
Title: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Summary: Genetic variants linked to inflammation and programmed cell death may affect the risk for ulcerative colitis.
Title: A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
Summary: A genetic variant on chromosome 6 may be linked to dilated cardiomyopathy.
Title: Genome-wide association study of cerebral small vessel disease reveals established and novel loci
Summary: Identification of novel genetic variants linked to cerebral small vessel disease, which can cause a variety of cognitive symptoms.
Title: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risks
Summary: Identification of 32 novel genetic variants associated with high blood pressure.
Title: Genome-wide meta-analysis identifies new susceptibility loci for migraine
Summary: Identification of genetic variants associated with migraines and synaptic function.
Title: Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Summary: Identification of novel genetic variants associated with same-sex sexual behavior.
Title: Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk variants
Summary: Identification of 7 novel genetic variants that may confer an increased risk of developing rheumatoid arthritis.
Title: Identification of common genetic risk variants for autism spectrum disorder
Summary: Identification of novel genetic variants linked to autism spectrum disorder.
Title: Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
Summary: A study of over 1 million participants identified 82 novel genetic variants associated with chronic kidney disease.
Title: Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
Summary: Identification of a novel genetic variant that is associated with prolonged gestational duration (pregnancy).
Title: Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics
Summary: Identification of 4 novel genetic variants correlated with handedness.
Title: Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease
Summary: Identification of over 100 novel genetic variants correlated with fat build-up around the body’s internal organs.
Title: GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
Summary: Identification of 4 novel genetic variants that correlate with childhood growth and BMI.
Title: Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
Summary: Genome-wide identification of 68 variants associated with albuminuria, a key indicator of chronic kidney disease.
Title: Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness
Summary: Detection of 19 genetic variants associated with feelings of loneliness.
Title: Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness
Summary: Detection of 19 genetic variants associated with feelings of loneliness.
Title: Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse
Summary: Genome-wide analysis reveals a novel genetic loci correlated with syncope, or fainting.
Title: Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
Summary: Identification of 25 genetic loci that are associated with an increased risk of gastroesophageal reflux disease.
Title: A genome-wide investigation of food addiction
Summary: Identification of 2 genetic loci correlated with the development of food addiction.
Title: Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits
Summary: Identification of 4 genetic variants associated with psychotic experiences.
Title: GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank
Summary: Identification of 44 genetic variants associated with age-related hearing impairment.
Title: Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Summary: Identification of 233 novel variants associated with multiple sclerosis and the body’s immune response system.
Title: Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Summary: Identification of 147 novel genetic variants associated with gout development.
Title: Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Summary: Discovery of novel genetic variants associated with an increased risk of chronic lymphocytic leukemia.
Title: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Summary: Identification of 5 novel genetic loci correlated to a person’s risk of developing late-onset Alzheimer’s disease.