Densidad ósea (Kemp, 2017)

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TÍTULO DEL ESTUDIO: Identificación de 153 nuevos loci asociados con la densidad mineral ósea del talón y la participación funcional de GPC6 en la osteoporosis

RESUMEN: Identificación de 153 nuevas variantes genéticas asociadas a la densidad mineral ósea.

VISIÓN GENERAL: La densidad mineral ósea es la cantidad de mineral óseo en el tejido óseo. Una alta densidad mineral ósea significa huesos más fuertes y un menor riesgo de fracturas y osteoporosis. Este estudio de todo el genoma analizó los genomas de más de 142.000 individuos de ascendencia europea y descubrió 153 variantes genéticas novedosas que están asociadas con la densidad mineral ósea. En total, el estudio informa 307 variantes genéticas independientes que explican en conjunto ~ 12% de la variación en la densidad mineral ósea. El estudio también vincula muchas variantes asociadas a la densidad mineral ósea con el riesgo de fracturas y osteoporosis.

¿SABÍAS? Para mantener sus huesos sanos, adopte una dieta rica en proteínas y calcio, haga ejercicio con regularidad (en particular, correr o hacer ejercicio con pesas) y abstenerse de consumir alcohol y tabaco. [SOURCE]

RESULTADOS DE LA MUESTRA: Más información sobre el Biblioteca de investigación de nebulosa .

VARIANTES ASOCIADAS A LA DENSIDAD ÓSEA: rs2536195, rs10668066, rs4869744, rs7741021, rs7099953, rs2941741, rs4233949, rs115242848, rs1414660, rs7255601, rs649693, rs10130587, rs1159798, rs9402490, rs1878526, rs1717731, rs10858944, rs6589301, rs71446481, rs6956946, rs35401268, rs12525051, rs4505759, rs34963268, rs58973023, rs113166754, rs4440558, rs9491689, rs10931982, rs62159864, rs34138479, rs35713211, rs1941749, rs11029901, rs117481343, rs370387, rs2929308, rs7576689, rs7209826, rs118115924, rs134639, rs11364492, rs2504069, rs10276670, rs35816040, rs1048932, rs7519889, rs12806687, rs17236800, rs1036902, rs11088458, rs10713212, rs947091, rs2008411, rs1980854, rs62198536, rs117111740, rs17662822, rs143243230, rs188810925, rs71378512, rs17457340, rs6117854, rs72829754, rs547545, rs112069922, rs2737252, rs4988321, rs144647275, rs344083, rs150694678, rs144339224, rs11636403, rs757980, rs34952318, rs212417, rs11209240, rs3829241, rs72805220, rs6040006, rs85, rs525678, rs61887821, rs71390846, rs6134038, rs4397637, rs17680862, rs7 959.604, rs149333699, rs17602572, rs7527300, rs10244184, rs7088220, rs884205, rs56928337, rs3790608, rs2708632, rs34136481, rs537120594, rs62558340, rs114847962, rs2696264, rs9932220, rs4807629, rs2275707, rs8002850, rs10199437, rs1133400, rs56082403, rs1386625, rs10249754, rs72655796, rs10992867, rs6839437, rs10490046, rs2836613, rs17307280, rs11228219, rs62028332, rs7003794, rs170634, rs377062541, rs5880046, rs3092018, rs202234992, rs2668602, rs2301522, rs62621812, rs66864335, rs12241932, rs1352014, rs8108787, rs4675694, rs10875906, rs4959677, rs74971894, rs12041600, rs17507577, rs201324539, rs587729126, rs2376600, rs1877998, rs71059192, rs9379084, rs7074558, rs5952416, rs239677, rs368510, rs72868839, rs11869530, rs11637971, rs6680737, rs13044413, rs28550561, rs13056435, rs6701290, rs2542710, rs1415701, rs11915970, rs139603701, rs559181, rs35417399, rs1042704, rs1428968, rs11832031, rs10790255, rs117108011, rs34725069, rs184953495, rs62195575, rs11679645, rs6454314, rs73997493, rs7411 9759, rs187925403, rs6040068, rs1080789, rs10943130, rs7535122, rs2675952, rs143581991, rs2509353, rs16961974, rs6489548, rs11875132, rs10145299, rs603424, rs77630528, rs3170167, rs7301013, rs12154498, rs17688827, rs3095208, rs7516171, rs56969212, rs28744551, rs2279743, rs6547870, rs149504726, rs72976751, rs1622638, rs1078514, rs17514738, rs74439044, rs8069036, rs17501090, rs78015143, rs55787537, rs6471752, rs2624847, rs11067228, rs56185026, rs1487241, rs9260426, rs10022648, rs12529766, rs6761129, rs4589135, rs191147097, rs10013456, rs557266652, rs62454420, rs183979857, rs1005502, rs11196171, rs56235417, rs35363078, rs17595156, rs4888151, rs13345456, rs73029263, rs72767980, rs371471055, rs75077113, rs147048550, rs147720516, rs7969076, rs34687052, rs9327301, rs68192277, rs7578166, rs2188092, rs10885447, rs283324, rs4806832, rs28587205, rs10749436, rs6882422, rs55874297, rs12340775, rs113196631, rs1149821, rs4239232, rs143043662, rs201402819, rs11729023, rs62164915, rs1502199, rs7036453, rs302101, rs34202212, rs1724298, rs1560633, rs11133474, rs9972653, rs10206992, rs78180894, rs4360494, rs5860048, rs528738, rs142515962, rs3776221, rs34588551, rs17598132, rs1323168, rs6870556, rs58057291, rs4505077, rs371350765, rs10637379, rs12714415, rs13328356, rs174574, rs111506224, rs4818988, rs72635657, rs133441, rs8023466, rs35498021, rs7069328, rs633891, rs76243438, rs4708620, rs72186592

RECURSOS ADICIONALES:
Densidad mineral del hueso
Osteoporosis

ACTUALIZACIÓN SEMANAL: 23 de noviembre de 2019