TITRE DE L’ÉTUDE: Identification de 153 nouveaux loci associés à la densité minérale osseuse du talon et à l’implication fonctionnelle de GPC6 dans l’ostéoporose
SOMMAIRE: Identification de 153 nouvelles variantes génétiques associées à la densité minérale osseuse.
APERÇU: La densité minérale osseuse est la quantité de minéral osseux dans le tissu osseux. Une densité minérale osseuse élevée signifie des os plus solides et un risque moindre de fractures et d’ostéoporose. Cette étude à l’échelle du génome a analysé les génomes de plus de 142 000 individus d’ascendance européenne et découvert 153 nouvelles variantes génétiques associées à la densité minérale osseuse. Au total, l’étude rapporte 307 variantes génétiques indépendantes qui expliquent conjointement ~ 12% de la variance de la densité minérale osseuse. L’étude relie également de nombreuses variantes associées à la densité minérale osseuse au risque de fractures et d’ostéoporose.
LE SAVIEZ-VOUS? Pour garder vos os en bonne santé, adoptez une alimentation riche en protéines et en calcium, faites de l’exercice régulièrement (en particulier la course à pied ou la mise en charge), et abstenez-vous de consommer de l’alcool et du tabac. [SOURCE]
EXEMPLE DE RÉSULTATS: En savoir plus sur Bibliothèque de recherche sur la nébuleuse .
VARIANTES ASSOCIÉES À LA DENSITÉ OSSEUSE: rs2536195, rs10668066, rs4869744, rs7741021, rs7099953, rs2941741, rs4233949, rs115242848, rs1414660, rs7255601, rs649693, rs10130587, rs1159798, rs9402490, rs1878526, rs1717731, rs10858944, rs6589301, rs71446481, rs6956946, rs35401268, rs12525051, rs4505759, rs34963268, rs58973023, rs113166754, rs4440558, rs9491689, rs10931982, rs62159864, rs34138479, rs35713211, rs1941749, rs11029901, rs117481343, rs370387, rs2929308, rs7576689, rs7209826, rs118115924, rs134639, rs11364492, rs2504069, rs10276670, rs35816040, rs1048932, rs7519889, rs12806687, rs17236800, rs1036902, rs11088458, rs10713212, rs947091, rs2008411, rs1980854, rs62198536, rs117111740, rs17662822, rs143243230, rs188810925, rs71378512, rs17457340, rs6117854, rs72829754, rs547545, rs112069922, rs2737252, rs4988321, rs144647275, rs344083, rs150694678, rs144339224, rs11636403, rs757980, rs34952318, rs212417, rs11209240, rs3829241, rs72805220, rs6040006, rs85, rs525678, rs61887821, rs71390846, rs6134038, rs4397637, rs17680862, rs7 959604, rs149333699, rs17602572, rs7527300, rs10244184, rs7088220, rs884205, rs56928337, rs3790608, rs2708632, rs34136481, rs537120594, rs62558340, rs114847962, rs2696264, rs9932220, rs4807629, rs2275707, rs8002850, rs10199437, rs1133400, rs56082403, rs1386625, rs10249754, rs72655796, rs10992867, rs6839437, rs10490046, rs2836613, rs17307280, rs11228219, rs62028332, rs7003794, rs170634, rs377062541, rs5880046, rs3092018, rs202234992, rs2668602, rs2301522, rs62621812, rs66864335, rs12241932, rs1352014, rs8108787, rs4675694, rs10875906, rs4959677, rs74971894, rs12041600, rs17507577, rs201324539, rs587729126, rs2376600, rs1877998, rs71059192, rs9379084, rs7074558, rs5952416, rs239677, rs368510, rs72868839, rs11869530, rs11637971, rs6680737, rs13044413, rs28550561, rs13056435, rs6701290, rs2542710, rs1415701, rs11915970, rs139603701, rs559181, rs35417399, rs1042704, rs1428968, rs11832031, rs10790255, rs117108011, rs34725069, rs184953495, rs62195575, rs11679645, rs6454314, rs73997493, rs7411 9759, rs187925403, rs6040068, rs1080789, rs10943130, rs7535122, rs2675952, rs143581991, rs2509353, rs16961974, rs6489548, rs11875132, rs10145299, rs603424, rs77630528, rs3170167, rs7301013, rs12154498, rs17688827, rs3095208, rs7516171, rs56969212, rs28744551, rs2279743, rs6547870, rs149504726, rs72976751, rs1622638, rs1078514, rs17514738, rs74439044, rs8069036, rs17501090, rs78015143, rs55787537, rs6471752, rs2624847, rs11067228, rs56185026, rs1487241, rs9260426, rs10022648, rs12529766, rs6761129, rs4589135, rs191147097, rs10013456, rs557266652, rs62454420, rs183979857, rs1005502, rs11196171, rs56235417, rs35363078, rs17595156, rs4888151, rs13345456, rs73029263, rs72767980, rs371471055, rs75077113, rs147048550, rs147720516, rs7969076, rs34687052, rs9327301, rs68192277, rs7578166, rs2188092, rs10885447, rs283324, rs4806832, rs28587205, rs10749436, rs6882422, rs55874297, rs12340775, rs113196631, rs1149821, rs4239232, rs143043662, rs201402819, rs11729023, rs62164915, rs1502199, rs7036453, rs302101, rs34202212, rs1724298, rs1560633, rs11133474, rs9972653, rs10206992, rs78180894, rs4360494, rs5860048, rs528738, rs142515962, rs3776221, rs34588551, rs17598132, rs1323168, rs6870556, rs58057291, rs4505077, rs371350765, rs10637379, rs12714415, rs13328356, rs174574, rs111506224, rs4818988, rs72635657, rs133441, rs8023466, rs35498021, rs7069328, rs633891, rs76243438, rs4708620, rs72186592
RESSOURCES ADDITIONNELLES:
Densité minérale osseuse
Ostéoporose
MISE À JOUR HEBDOMADAIRE: 23 novembre 2019
