TÍTULO DO ESTUDO: Identificação de 153 novos loci associados à densidade mineral óssea do calcanhar e envolvimento funcional de GPC6 na osteoporose
RESUMO: Identificação de 153 novas variantes genéticas associadas à densidade mineral óssea.
VISÃO GERAL: A densidade mineral óssea é a quantidade de mineral ósseo no tecido ósseo. Alta densidade mineral óssea significa ossos mais fortes e menor risco de fraturas e osteoporose. Este estudo do genoma analisou os genomas de mais de 142.000 indivíduos de ascendência europeia e descobriu 153 novas variantes genéticas que estão associadas à densidade mineral óssea. No total, o estudo relata 307 variantes genéticas independentes que, em conjunto, explicam ~ 12% da variação na densidade mineral óssea. O estudo também relaciona muitas variantes associadas à densidade mineral óssea ao risco de fraturas e osteoporose.
VOCÊ SABIA? Para manter seus ossos saudáveis, adote uma dieta rica em proteínas e cálcio, faça exercícios regularmente (em particular, corrida ou exercícios de levantamento de peso), e abstenha-se de álcool e tabaco. [SOURCE]
RESULTADOS DE AMOSTRA: Saiba mais sobre o Nebula Research Library .
VARIANTES ASSOCIADAS À DENSIDADE ÓSSEA: rs2536195, rs10668066, rs4869744, rs7741021, rs7099953, rs2941741, rs4233949, rs115242848, rs1414660, rs7255601, rs649693, rs10130587, rs1159798, rs9402490, rs1878526, rs1717731, rs10858944, rs6589301, rs71446481, rs6956946, rs35401268, rs12525051, rs4505759, rs34963268, rs58973023, rs113166754, rs4440558, rs9491689, rs10931982, rs62159864, rs34138479, rs35713211, rs1941749, rs11029901, rs117481343, rs370387, rs2929308, rs7576689, rs7209826, rs118115924, rs134639, rs11364492, rs2504069, rs10276670, rs35816040, rs1048932, rs7519889, rs12806687, rs17236800, rs1036902, rs11088458, rs10713212, rs947091, rs2008411, rs1980854, rs62198536, rs117111740, rs17662822, rs143243230, rs188810925, rs71378512, rs17457340, rs6117854, rs72829754, rs547545, rs112069922, rs2737252, rs4988321, rs144647275, rs344083, rs150694678, rs144339224, rs11636403, rs757980, rs34952318, rs212417, rs11209240, rs3829241, rs72805220, rs6040006, rs85, rs525678, rs61887821, rs71390846, rs6134038, rs4397637, rs17680862, rs7 959.604, rs149333699, rs17602572, rs7527300, rs10244184, rs7088220, rs884205, rs56928337, rs3790608, rs2708632, rs34136481, rs537120594, rs62558340, rs114847962, rs2696264, rs9932220, rs4807629, rs2275707, rs8002850, rs10199437, rs1133400, rs56082403, rs1386625, rs10249754, rs72655796, rs10992867, rs6839437, rs10490046, rs2836613, rs17307280, rs11228219, rs62028332, rs7003794, rs170634, rs377062541, rs5880046, rs3092018, rs202234992, rs2668602, rs2301522, rs62621812, rs66864335, rs12241932, rs1352014, rs8108787, rs4675694, rs10875906, rs4959677, rs74971894, rs12041600, rs17507577, rs201324539, rs587729126, rs2376600, rs1877998, rs71059192, rs9379084, rs7074558, rs5952416, rs239677, rs368510, rs72868839, rs11869530, rs11637971, rs6680737, rs13044413, rs28550561, rs13056435, rs6701290, rs2542710, rs1415701, rs11915970, rs139603701, rs559181, rs35417399, rs1042704, rs1428968, rs11832031, rs10790255, rs117108011, rs34725069, rs184953495, rs62195575, rs11679645, rs6454314, rs73997493, rs7411 9759, rs187925403, rs6040068, rs1080789, rs10943130, rs7535122, rs2675952, rs143581991, rs2509353, rs16961974, rs6489548, rs11875132, rs10145299, rs603424, rs77630528, rs3170167, rs7301013, rs12154498, rs17688827, rs3095208, rs7516171, rs56969212, rs28744551, rs2279743, rs6547870, rs149504726, rs72976751, rs1622638, rs1078514, rs17514738, rs74439044, rs8069036, rs17501090, rs78015143, rs55787537, rs6471752, rs2624847, rs11067228, rs56185026, rs1487241, rs9260426, rs10022648, rs12529766, rs6761129, rs4589135, rs191147097, rs10013456, rs557266652, rs62454420, rs183979857, rs1005502, rs11196171, rs56235417, rs35363078, rs17595156, rs4888151, rs13345456, rs73029263, rs72767980, rs371471055, rs75077113, rs147048550, rs147720516, rs7969076, rs34687052, rs9327301, rs68192277, rs7578166, rs2188092, rs10885447, rs283324, rs4806832, rs28587205, rs10749436, rs6882422, rs55874297, rs12340775, rs113196631, rs1149821, rs4239232, rs143043662, rs201402819, rs11729023, rs62164915, rs1502199, rs7036453, rs302101, rs34202212, rs1724298, rs1560633, rs11133474, rs9972653, rs10206992, rs78180894, rs4360494, rs5860048, rs528738, rs142515962, rs3776221, rs34588551, rs17598132, rs1323168, rs6870556, rs58057291, rs4505077, rs371350765, rs10637379, rs12714415, rs13328356, rs174574, rs111506224, rs4818988, rs72635657, rs133441, rs8023466, rs35498021, rs7069328, rs633891, rs76243438, rs4708620, rs72186592
RECURSOS ADICIONAIS:
Densidade mineral óssea
Osteoporose
ATUALIZAÇÃO SEMANAL: 23 de novembro de 2019
