SUMMARY: Risk of ulcerative colitis may be influenced by variants that play a role in cell adhesion.
DESCRIPTION: Ulcerative colitis (UC) occurs in the large intestine when the lining of the colon becomes inflamed, forming ulcers (open sores). To better understand the genetic risk factors that may predispose a person to this condition, this genome-wide association study examined 15,554 individuals of European descent. The study found variants near 3 genes that are associated. The first variant was near the HNF4A gene, which plays a role in cell adhesion. The next significant variant, near the LAMB1 gene, helps cells stay attached to the walls in the intestines. The third variant was the CDH1 gene which was previously known to play a role in UC. Like the HNF4A gene, it helps cells adhere to one another.
DID YOU KNOW? Dietary changes, such as increasing fiber and reducing dairy, may help prevent some of the symptoms of UC. Drinking plenty of water and eating smaller, frequent meals may also help manage the symptoms of this disease. [SOURCE]
SAMPLE RESULTS: Learn more about the Nebula Research Library.
UC-ASSOCIATED VARIANTS: rs6017342, rs1728785, rs886774
WEEKLY UPDATE: July 23, 2019