STUDY TITLE: Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
SUMMARY: Identification of 255 genetic variants associated with the apolipoprotein B level in the blood and analysis of its contribution to the risk of coronary heart disease.
DESCRIPTION: Coronary heart disease (CHD) is a condition that develops when the heart’s arteries cannot supply enough oxygen to the heart muscle. Coronary heart disease is the leading cause of death in the United States. It occurs when plaque builds up in the heart’s arteries and blocks the blood flow to the heart. Arterial plaque consists of multiple substances that circulate in the blood, in particular fats and cholesterol. Fats and cholesterol cannot travel around the bloodstream on their own and instead must be transported by proteins called “apolipoproteins”. In particular, LDL cholesterol, the “bad” cholesterol, relies on transport by apolipoprotein B (apoB). As a result of this connection, elevated levels of apolipoprotein B are linked to elevated LDL cholesterol and an increased risk of coronary heart disease. This study examined genetic data of over 440,000 individuals of European descent to identify genomic regions associated with apolipoprotein B levels in the blood. The researchers identified 250 genetic variants, including 203 novel variants, associated with apolipoprotein B levels. Further analysis identified increased apolipoprotein B levels as the main contributor to an increased risk of coronary heart disease. In other words, elevated levels of fats and cholesterol alone will generally not lead to a significantly increased risk of coronary heart disease. However, the risk does increase when the levels of apolipoprotein B are increased as well.
DID YOU KNOW? Many of the same dietary recommendations are made for lowering apolipoprotein B as for lowering LDL cholesterol. These include limiting the consumption of saturated fats, such as those found in fried foods and some dairy products, and instead turning to vegetables and fiber-rich foods. [SOURCE]
SAMPLE RESULTS: Learn more about the Nebula Research Library.
APOLIPOPROTEIN B LEVEL-ASSOCIATED VARIANTS: rs55739424, rs4965894, rs6714750, rs56402930, rs72638977, rs67038483, rs112220485, rs190104, rs115739682, rs28768427, rs142787485, rs2256814, rs10962680, rs34931250, rs546240, rs399970, rs189052, rs1862719, rs77312476, rs56264193, rs12443634, rs2517473, rs7260871, rs62049427, rs35882350, rs7601153, rs7776054, rs10151436, rs147539187, rs10876450, rs61754230, rs2761311, rs145090930, rs72663045, rs138354, rs114802991, rs6560499, rs2137234, rs12970, rs71562509, rs6426328, rs913499, rs13283282, rs17457613, rs73025516, rs45537841, rs12948283, rs3821838, rs11014154, rs60856912, rs112987086, rs188608977, rs72749770, rs1250258, rs6667939, rs80276949, rs41434449, rs2124034, rs12471768, rs1229984, rs13379043, rs10851478, rs576573069, rs377181093, rs145725232, rs2058122, rs3780181, rs1561139, rs72733928, rs62120394, rs278981, rs4485425, rs7108486, rs1495741, rs2705619, rs139915535, rs17476364, rs142385484, rs969075, rs7601412, rs28406917, rs13394970, rs79931565, rs10858093, rs55921103, rs560238897, rs4771674, rs2063643, rs58148580, rs1556562, rs74454529, rs10432370, rs17447211, rs7603427, rs719148, rs56113850, rs13230111, rs12948394, rs656521, rs12197047, rs112426331, rs59104589, rs12054451, rs150820726, rs1800961, rs11693526, rs9832727, rs12720796, rs581080, rs11568318, rs7249565, rs10896125, rs10953298, rs141469619, rs71311871, rs3822855, rs55804343, rs12078100, rs12046278, rs2021092, rs1358980, rs6090101, rs1458038, rs117139027, rs59328596, rs12246352, rs112403212, rs9616822, rs3932048, rs17036085, rs145730801, rs72823020, rs146534110, rs2807854, rs3096644, rs9298506, rs2122982, rs73075609, rs233721, rs473224, rs1003533, rs6050464, rs224424, rs57754494, rs13076933, rs12990177, rs13389219, rs10448340, rs2925677, rs9496567, rs112758337, rs62120573, rs2160994, rs2737263, rs1888488, rs13247874, rs3823379, rs3936511, rs11057397, rs6475606, rs55831924, rs113743631, rs6907508, rs12603885, rs115704890, rs2335708, rs9491697, rs1265097, rs4782568, rs704, rs9834932, rs7569317, rs4671050, rs113177823, rs76079263, rs72631343, rs4722551, rs34767236, rs10832963, rs9884390, rs115692156, rs7012637, rs9471975, rs7734476, rs261290, rs4935356, rs1169292, rs72888603, rs6602909, rs150474434, rs11621792, rs7746081, rs6093446, rs11601507, rs597808, rs13108218, rs1801689, rs35081008, rs2238162, rs10127775, rs188247550, rs117733303, rs2068888, rs17050272, rs2073547, rs11206517, rs116734477, rs55714927, rs6709904, rs138692741, rs114165349, rs72848251, rs13702, rs9297994, rs61775180, rs4470903, rs12239737, rs2618566, rs79220007, rs36043200, rs6689611, rs6874202, rs516316, rs112771035, rs115478735, rs12208357, rs1883711, rs6073958, rs77542162, rs556107, rs73045960, rs76186504, rs34042070, rs472495, rs148601586, rs174564, rs375972689, rs2738447, rs3764261, rs4299376, rs118039278, rs60403635, rs8107974, rs1260326, rs964184, rs12916, rs12691088, rs28601761, rs6657811, rs62122481, rs11591147, rs62119267, rs113330691, rs143020224, rs531660643
Coronary Heart Disease (Video)
Coronary Heart Disease
WEEKLY UPDATE: April 5, 2020