Stroke volume (Pirruccello, 2020)

model of heart on medical textbook

STUDY TITLE: Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy

SUMMARY: Identification of 12 genetic variants associated with the heart’s stroke volume.

OVERVIEW: The human heart is a muscle that pumps blood throughout the body. It consists of 4 chambers: 2 atria (left and right) and 2 ventricles (left and right). Blood that has been enriched with oxygen in the lungs enters the left atrium and then flows into the left ventricle from where it’s pumped to all other parts of the body. Stroke volume (SV) is a measurement of how much blood is pumped out of the left ventricle during each beat. The average SV is 81mL for women and 95mL for men. Measurements of stroke volume can indicate if the heart is pumping enough blood to meet the body’s demands. This genome-wide association study of over 36,000 individuals of European ancestry identified 12 genetic variants correlated with SV including variants near genes that play a role in heart muscle contraction (MYH6) and formation of blood vessels (VEGFA). Together these variants explain ~ 34% of stroke volume heritability. The study also found a strong inverse relationship between the polygenic score for larger SV and hypothyroidism.

DID YOU KNOW? During exercise, the body needs an increased supply of blood to deliver oxygen to the muscles. Over time, exercise can lead to an increase in the heart’s efficiency, pumping more blood with less work. Aerobic activities such as running and cycling are particularly effective at increasing stroke volume. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

stroke volume sample results

SV-ASSOCIATED VARIANTS: rs72967533, rs11065979, rs7573293, rs11066188, rs10400419, rs888690, rs422068, rs111721712, rs2891403, rs2146324, rs28391274, rs143384

The heart (Video)
Stroke volume and heart rate (Video)

Left ventricular ejection fraction (Pirruccello, 2020)
Left ventricular end-diastolic volume (Pirruccello, 2020)
Left ventricular end-systolic volume (Pirruccello, 2020)
Heart failure (Shah, 2020)

WEEKLY UPDATE: May 19, 2020