SUMMARY: This study identified novel genetic variants that may influence the subcortical brain structures which are involved in complex activities including movement, emotions, and learning.
DESCRIPTION: The subcortical region consists of structures located below the outer layer of the brain. These structures have functions related to regulation of movement, learning, memory, and motivation. In this study, the volume of the brain structures of 30,717 individuals was measured using Magnetic Resonance Imaging (MRI). The study identified associations between genetic variants and the volume of different subcortical structures. The strongest associations were found near developmental genes that regulate apoptosis (programmed cell death) and the growth of neurons. This discovery provides insight into the causes of variability in human brain development.
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BRAIN STRUCTURE-ASSOCIATED VARIANTS: rs945270, rs77956314, rs62097986, rs6087771, rs683250, rs61921502, rs1318862
WEEKLY UPDATE: July 26, 2019