RESUMO: Identificação de 534 variantes genéticas associadas ao HDL colesterol nível no sangue e análise de sua contribuição para o risco de doença cardíaca coronária.
DESCRIÇÃO: A doença coronariana (DCC) é uma condição que se desenvolve quando as artérias do coração não conseguem fornecer oxigênio suficiente para o músculo cardíaco. A doença coronariana é a principal causa de morte nos Estados Unidos. Ocorre quando placa acumula-se nas artérias do coração e bloqueia o fluxo sanguíneo para o coração. Arterial placa consiste em várias substâncias que circulam no sangue. Uma das substâncias que o estudo examinou é o HDL (lipoproteína de alta densidade) colesterol , também conhecido como o “bom” colesterol . Para tanto, este estudo analisou dados genéticos de mais de 440.000 indivíduos de ascendência europeia para identificar regiões genômicas associadas ao HDL. colesterol níveis no sangue. Os pesquisadores identificaram 534 variantes genéticas, incluindo 383 novas variantes, associadas ao HDL colesterol níveis. A análise mostrou que um HDL alto colesterol nível está associado a uma diminuição do risco de doença cardíaca coronária. No entanto, essa associação enfraqueceu quando os pesquisadores consideraram todas as gorduras e proteínas no estudo. Os resultados do estudo ainda sugerem que HDL colesterol desempenha um papel importante no desenvolvimento de doenças cardíacas.
VOCÊ SABIA? O colesterol HDL é freqüentemente chamado de colesterol “bom” porque ajuda seu corpo a remover outros tipos de colesterol da corrente sanguínea. Algumas maneiras de aumentar os níveis de colesterol HDL incluem exercícios e uma dieta baixa em gorduras trans. [SOURCE]
RESULTADOS DE AMOSTRA: Saiba mais sobre o Nebula Research Library .
VARIANTES ASSOCIADAS AO NÍVEL DE COLESTEROL HDL: rs9989419, rs1800588, rs1601934, rs343, rs964184, rs77960347, rs8086351, rs79600951, rs2740488, rs72836561, rs2281718, rs116843064, rs429358, rs174566, rs9987289, rs80005209, rs6073958, rs1800961, rs676210, rs11789603, rs13107325, rs1052373, rs2943645, rs10162642, rs12976395, rs921919, rs141469619, rs55781197, rs3768321, rs308, rs571848809, rs367070, rs686030, rs2925979, rs4871603, rs998584, rs75609851, rs737338, rs1054852, rs2792751, rs6469605, rs2066714, rs113740515, rs545858676, rs78058190, rs145276599, rs35493868, rs4731701, rs4969141, rs7136506, rs11658786, rs150844304, rs12422125, rs12224170, rs140584594, rs11228871, rs13389219, rs11228212, rs3184504, rs17138358, rs61352607, rs2263329, rs7817574, rs2256609, rs559355, rs2642438, rs6902116, rs58473820, rs193084249, rs2498786, rs11239536, rs79153732, rs61805075, rs116978226, rs12740374, rs3936511, rs7308864, rs56271783, rs144311893, rs13235365, rs11045171, rs6765484, rs771481, rs75662196, rs9647335, rs112001035, rs11967891, rs427301 0, rs62102718, rs35137994, rs12411732, rs75152587, rs4239651, rs10513801, rs2298624, rs11664369, rs133015, rs72959041, rs10233430, rs2297402, rs6824451, rs61435086, rs72823020, rs12928099, rs1043897, rs1047964, rs3775228, rs11066320, rs2523978, rs17326656, rs2068888, rs77403571, rs632057, rs6542680, rs72647336, rs62271373, rs73243877, rs72926946, rs11645157, rs9817452, rs2159607, rs142288236, rs2307111, rs10955991, rs4871624, rs7750688, rs7757193, rs142493909, rs907866, rs4650994, rs7925100, rs532436, rs267738, rs17309930, rs3129797, rs235314, rs1047891, rs3803501, rs7170463, rs13379043, rs8081548, rs117687565, rs142965311, rs10750766, rs12485478, rs3736802, rs6499102, rs1534696, rs2963468, rs55935382, rs12510382, rs1468642, rs112771035, rs3129962, rs11605837, rs10774579, rs4686739, rs2435307, rs74419430, rs11880219, rs6934962, rs2247355, rs4930352, rs66763009, rs1132274, rs10774439, rs34138141, rs62492368, rs10786114, rs11640494, rs9622830, rs703966, rs2289863, rs74735576, rs3814883, rs557933, rs11658872, rs10846690, rs16928809, rs2804894, rs35777071, rs13097947, rs34675318, rs141062196, rs8014289, rs10504477, rs1168114, rs3763236, rs830620, rs3732356, rs2862954, rs12650112, rs1446585, rs11118320, rs9608972, rs12150914, rs11075985, rs9604045, rs1045241, rs13076933, rs2723065, rs9274346, rs11231138, rs2268840, rs59104589, rs4356188, rs13220570, rs77631377, rs595767, rs77605964, rs3749748, rs41292412, rs116006942, rs367677, rs143474489, rs6457807, rs2298632, rs9657541, rs117230571, rs13269725, rs4979372, rs62112763, rs577525, rs1055582, rs2314338, rs3747973, rs78025076, rs6123685, rs9646167, rs4760, rs28876383, rs2011614, rs1611719, rs10761737, rs7595075, rs7158166, rs4788446, rs138354839, rs28362901, rs144033177, rs2218793, rs7769059, rs4599108, rs587739738, rs62491176, rs2237035, rs968050, rs11057468, rs140201358, rs4800356, rs75817747, rs76428106, rs11170516, rs6924387, rs74456742, rs10252234, rs6664374, rs13147189, rs62486442, rs9347737, rs147525635, rs62338910, rs140064750, rs2071379, rs76602912, rs34555420, rs1225053, rs75572195, rs113710278, rs150237291, rs34940374, rs76213248, rs2964007, rs2520096, rs35706812, rs73221948, rs9469583, rs6590207, rs11601507, rs12803463, rs79634051, rs13263821, rs2705616, rs9980311, rs330042, rs11021232, rs11631178, rs12411959, rs1884589, rs113761591, rs12814794, rs2585398, rs374039502, rs72729582, rs2910949, rs67344323, rs2204886, rs74500135, rs11688682, rs16969990, rs11687520, rs1663626, rs13066793, rs62092069, rs13144151, rs838777, rs3733890, rs34695471, rs55652051, rs17740942, rs28712486, rs11254464, rs13042367, rs12045101, rs12975319, rs1771582, rs7583067, rs2781668, rs73457437, rs11878235, rs73082723, rs150300171, rs12516070, rs32578, rs62428831, rs72801474, rs12686780, rs4875043, rs10950390, rs61884030, rs22 98214, rs15052, rs68006638, rs9884482, rs13323506, rs183078, rs4654395, rs78595810, rs17041868, rs61926301, rs185073199, rs7036107, rs72654647, rs112192770, rs200540247, rs248653, rs1240820, rs56105022, rs1086056, rs4078216, rs55801554, rs9877304, rs11043221, rs17566828, rs2417125, rs11883967, rs4947121, rs738409, rs10896581, rs183906992, rs2965169, rs11961755, rs62565259, rs2098918, rs77234291, rs1252425, rs77916918, rs7488780, rs72805692, rs2551980, rs4976033, rs61919816, rs6021914, rs73179655, rs113261881, rs28510484, rs74328314, rs12998038, rs57074291, rs10916239, rs1970811, rs75032664, rs7725218, rs6790951, rs8126001, rs13041173, rs3794752, rs1818917, rs11878604, rs1431659, rs72755439, rs13111599, rs2364723, rs7622114, rs7658082, rs9646934, rs254559, rs12921195, rs1412234, rs34717889, rs61596977, rs1083470, rs11171710, rs73151974, rs76530346, rs58298943, rs9526023, rs17124112, rs115912456, rs7251640, rs10438354, rs3825669, rs16975758, rs6940493, rs34720381, rs1894544, rs549058, rs 8127283, rs75246752, rs34830321, rs1349852, rs10826337, rs7903537, rs1155347, rs117499775, rs2100692, rs4691379, rs11938781, rs1862205, rs141440048, rs2339234, rs57348955, rs6806529, rs12926854, rs567056, rs76246107, rs4855582, rs56017932, rs2245477, rs2645979, rs79311290, rs11653260, rs2534596, rs6874833, rs6131012, rs7650845, rs6059958, rs3859588, rs6987377, rs75479205, rs11009262, rs1395221, rs201441, rs6738438, rs7316878, rs12146566, rs13300004, rs2362541, rs35580606, rs6762415, rs7826177, rs12692596, rs42125, rs6002946, rs680321, rs2750411, rs38166, rs4755720, rs8102873, rs10879184, rs11000468, rs11948445, rs139828053, rs2456722, rs35828909, rs36092527, rs10901802, rs34559316, rs61905599, rs7039168, rs1411432, rs7218647, rs9610329, rs16885512, rs2175766, rs13195251, rs28455602, rs3746915, rs4410790, rs56131490, rs61748951, rs12713007, rs4550673, rs514924, rs79616633, rs4997370, rs1955512, rs4924471, rs12705595, rs6893139, rs144567740, rs2414178, rs11202156, rs1517500, rs17185038, rs2302367, rs11546878, rs1012306, rs2663924, rs3903399, rs61993685, rs117435644, rs7188071, rs2155220, rs12119128, rs11622947, rs502627, rs78456138, rs546436456, rs73455693, rs12986742, rs67934334, rs454968, rs1760940, rs59737437, rs880674, rs1567353, rs445841, rs550916783, rs138026745, rs4233367, rs407133, rs254024, rs118128493
RECURSOS ADICIONAIS:
Doença cardíaca coronária (vídeo)
Doença Cardíaca Coronariana
Colesterol LDL e HDL: colesterol “ruim” e “bom”
ATUALIZAÇÃO SEMANAL: 5 de abril de 2020
