TITRE DE L’ÉTUDE: Définition du rôle de la variation commune dans l’architecture génomique et biologique de la taille humaine adulte
TITRE DE L’ÉTUDE: Identification à l’échelle du génome de 687 variantes associées à la hauteur.
APERÇU: Au cours des 150 dernières années, la taille moyenne de l’homme a augmenté d’environ 4 pouces. Alors que les facteurs environnementaux comme la nutrition ont une forte influence sur la croissance du corps humain, il est clair que la taille est un trait hautement héréditaire. En fait, on pense que jusqu’à 80% de la taille d’une personne est génétiquement déterminée! Cependant, la hauteur est un trait très complexe influencé par de nombreuses variantes du génome. Pour identifier les variantes génétiques associées à la taille, cette étude a examiné plus de 250 000 individus d’ascendance européenne. Les chercheurs ont découvert 697 variantes génétiques associées à la taille. Prises ensemble, ces variantes expliquent ~ 16% des différences de hauteur observées entre les personnes. Certains des variants identifiés sont proches de gènes impliqués dans le développement des os et du cartilage.
LE SAVIEZ-VOUS? À partir de 40 ans environ, de nombreuses personnes commencent à perdre de la hauteur. Cela peut être dû à plusieurs facteurs, tels que la compression vertébrale liée à l’âge et des troubles comme l’ostéoporose. L’exercice et une alimentation saine (y compris beaucoup de calcium) peuvent aider à maintenir des os et des muscles solides et à limiter la perte de taille. [LA SOURCE ]
EXEMPLE DE RÉSULTATS: En savoir plus sur Bibliothèque de recherche sur la nébuleuse .
VARIANTES ANALYSÉES: rs724016, rs7692995, rs3791679, rs8756, rs143384, rs798497, rs3760318, rs806794, rs4896582, rs720390, rs4369779, rs3814333, rs3825199, rs12214804, rs552707, rs2079795, rs1155939, rs9292468, rs10859567, rs9392918, rs17556750, rs314263, rs1074683, rs4733724, rs7701414, rs3811958, rs2284746, rs42039, rs1036821, rs9428104, rs7870753, rs7652177, rs2093210, rs12538407, rs5742915, rs9650315, rs2289195, rs3118905, rs1884897, rs9967417, rs991967, rs3800461, rs2871865, rs4986172, rs1367226, rs11049611, rs1812175, rs4548838, rs4735677, rs1535466, rs16942341, rs7033487, rs10748128, rs10958476, rs7849585, rs4448343, rs2854207, rs526896, rs961014, rs11880992, rs7466269, rs2974438, rs16860216, rs6439168, rs2856321, rs11684404, rs6696239, rs6894139, rs1401795, rs4337252, rs9993613, rs6714546, rs181338, rs11144688, rs17450430, rs1681630, rs817300, rs862034, rs9217, rs1815314, rs4974480, rs606452, rs9328445, rs7043114, rs994533, rs1950500, rs9835332, rs192336777, rs1233032252, rs192336777, rs1233032252, rs2536777, rs1233032255701 07, rs10948222, rs7980687, rs310421, rs6902771, rs7716219, rs897080, rs2806561, rs3807931, rs2280470, rs10780910, rs6600365, rs4620037, rs4803468, rs9880211, rs7154721, rs3020418, rs422421, rs12474201, rs12209223, rs7027110, rs1582931, rs7731703, rs12347744, rs509035, rs584828, rs7733195, rs7534365, rs12470505, rs2074977, rs12639764, rs2278483, rs1047014, rs6955948, rs6577717, rs1659127, rs10990303, rs6974574, rs7551732, rs227724, rs301901, rs13177718, rs6920372, rs11648796, rs2888877, rs2421992, rs822531, rs2597513, rs1325596, rs648831, rs2413143, rs7971536, rs291979, rs4072910, rs6879260, rs2390151, rs3958122, rs12779328, rs2237886, rs6540834, rs2956605, rs2028067, rs17511102, rs16859517, rs2425163, rs10152591, rs564914, rs7899004, rs763318, rs4652773, rs425277, rs39623, rs975210, rs8052560, rs2013265, rs7605699, rs1233627, rs2338115, rs10119624, rs2306694, rs4246302, rs6761041, rs4812586, rs1415701, rs8180991, rs8073371, rs955748, rs170819356, rs1630748, rs170819356, rs16308 42, rs3790086, rs3782089, rs4332428, rs2302580, rs891088, rs1329393, rs7126398, rs11867479, rs11633371, rs10883563, rs318095, rs749052, rs9816693, rs7319045, rs8006657, rs1562975, rs2377058, rs6903448, rs10843390, rs2857693, rs2834442, rs4601530, rs1265097, rs7853235, rs13088462, rs6594336, rs4428898, rs7561273, rs6457374, rs3767627, rs10767838, rs12204421, rs2070776, rs16895130, rs6485978, rs632124, rs7112925, rs17792664, rs3923086, rs1550162, rs12882130, rs11221442, rs1935157, rs757081, rs11880124, rs17391694, rs1599473, rs1405212, rs17603945, rs17721822, rs4640244, rs3014219, rs991946, rs3885668, rs6733349, rs12411277, rs2305833, rs6441170, rs6921207, rs7517682, rs1257763, rs1326023, rs12344396, rs389663, rs9456307, rs7568069, rs1753637, rs2072153, rs12904334, rs3809790, rs9889755, rs7177711, rs9404952, rs2211866, rs6694089, rs11659752, rs2300921, rs1864439, rs1190545, rs1980850, rs4246079, rs9766, rs3812591, rs26868, rs1809889, rs10877030, rs1658351, rs2811594, rs9409082, rs17807185, rs3812040, rs17163588, rs7567288, rs26024, rs11687941, rs34651, rs11599750, rs6899744, rs10131337, rs989393, rs540652, rs2123731, rs711245, rs13078528, rs2687950, rs3957165, rs1529701, rs10863936, rs11152213, rs6751657, rs316618, rs12120956, rs12855, rs4686904, rs3812423, rs10880969, rs4834927, rs10790381, rs6845999, rs12987566, rs16834765, rs2631676, rs17369123, rs354196, rs7567851, rs2378870, rs12323101, rs1546391, rs6919534, rs2510396, rs12125882, rs3828760, rs2781373, rs7273787, rs12926008, rs2257011, rs33852, rs902143, rs17032525, rs10794175, rs11047239, rs6988484, rs17806888, rs212524, rs6949739, rs4901537, rs8103068, rs8102380, rs12186664, rs1625895, rs9443804, rs8017130, rs7659107, rs1742829, rs2240919, rs4656220, rs780094, rs11745439, rs6838153, rs11175992, rs1838153, rs11175992, rs184248 0326, rs13006748, rs932445, rs568610, rs4320932, rs1996422, rs7069985, rs4425077, rs2662027, rs4239020, rs17574650, rs479744, rs6561319, rs3739707, rs1341278, rs2072268, rs11677466, rs2145357, rs3129254, rs2306596, rs6420435, rs7834383, rs7727731, rs17349981, rs7985356, rs13393800, rs12458127, rs165189, rs4868126, rs1036477, rs2149163, rs4802134, rs10152739, rs567401, rs8067165, rs3763631, rs10495098, rs12435366, rs4953951, rs17088184, rs32855, rs4357716, rs6085662, rs2509133, rs7774834, rs12693589, rs2044124, rs8058684, rs429433, rs17122659, rs2298265, rs7823327, rs12055154, rs11107062, rs9858528, rs2166898, rs12119525, rs6962887, rs2735469, rs12153391, rs1113765, rs4875421, rs17038954, rs9395264, rs9977276, rs8097893, rs12820411, rs17264185, rs6999671, rs11855014, rs1348002, rs915506, rs4725061, rs738288, rs956796, rs4883972, rs6061231, rs2763273, rs4624820, rs11618507, rs3791673, rs1533269, rs929637, rs16939034, rs1552173, rs2117563, rs217181, rs7712163, rs6917181, rs7712163, rs6917181, rs7712163, rs6417181, rs7712163, rs643564 24, rs10283100, rs497273, rs960006, rs2219320, rs12519505, rs9309101, rs2345835, rs10997979, rs8103992, rs6971575, rs4325879, rs1461503, rs11612228, rs782930, rs867245, rs2679184, rs11750568, rs13133465, rs4141885, rs9825951, rs2682587, rs2326458, rs6691924, rs6137287, rs2057291, rs7261425, rs4326884, rs1861908, rs6658763, rs3802758, rs8042424, rs17783015, rs1244981, rs11783655, rs11156098, rs12863103, rs10779751, rs761391, rs9841435, rs7253628, rs16994718, rs11799609, rs4843367, rs17499117, rs2164968, rs12533079, rs926438, rs6544089, rs17181956, rs2120335, rs17250196, rs129963, rs731874, rs9291926, rs1797625, rs6952113, rs6754426, rs1409156, rs7544462, rs2961830, rs2715094, rs13150868, rs6584575, rs2596831, rs11616380, rs1478610, rs11634405, rs1053996, rs209918, rs10492364, rs2099745, rs3927536, rs1614303, rs2014467, rs2238300, rs992157, rs199515, rs7259684, rs1055144, rs4605213, rs2046158, rs4350272, rs7654571, rs11722554, rs11640018, rs4344931, rs4895801, rs10401193, rs2748483, rs13388725, rs3116168, rs2915404, rs3817428, rs12871822, rs958225, rs273945, rs11661645, rs13183624, rs4713902, rs894343, rs6887276, rs11624136, rs10083886, rs5757318, rs10460566, rs6446315, rs820848, rs2343240, rs2633761, rs870183, rs2531992, rs11835818, rs11708412, rs10059761, rs7782764, rs1171615, rs12597498, rs12329133, rs1004202, rs3818416, rs6563199, rs16964211, rs12137162, rs13416119, rs2224538, rs8117259, rs2275325, rs10744956, rs10759774, rs6813055, rs163071, rs300039, rs11683207, rs10817960, rs11057552, rs953199, rs16968242, rs6020202, rs3132297, rs1576900, rs833706, rs703985, rs12615742, rs2451948, rs2888893, rs3748394, rs2188177, rs10140101, rs11714558, rs2058092, rs10766065, rs1945237, rs7299326, rs996743, rs2164747, rs11100790, rs11861084, rs999599, rs11616067, rs888403, rs1966913 0972, rs10048625, rs7170986, rs6596075, rs17330192, rs10972628, rs11198820, rs6511689, rs10962832, rs12454567, rs749234, rs17659078, rs4973429, rs2023693, rs1368380, rs6911389, rs8073177, rs17387330, rs11867943, rs11090631, rs6080830, rs14062, rs4243206, rs2247870, rs13113518, rs11950938, rs486359, rs1420023, rs17777628, rs11245515, rs8069300, rs12621643, rs17410035, rs7646824, rs6462432, rs6746356, rs1040941, rs4785393, rs6504389, rs1007358, rs4767473, rs7633464, rs2175513, rs936339, rs12914466, rs17075869, rs12513181, rs3169906, rs6688100, rs9327705, rs6829680, rs8028843, rs10995319, rs2059877, rs9405356, rs17113369, rs2167645, rs7097701, rs2272566, rs4746769, rs2815379, rs4674354, rs2034172, rs1014987, rs12669267, rs12731056, rs12228415, rs3026499, rs1544196, rs6794009, rs6762606, rs7162825, rs868489, rs11244750, rs11642612, RS17140875, rs2829941, rs2337143, rs11779459, rs1321666, rs6571772, rs12144094, rs4256170, rs3915129, rs7033940, rs7334755, rs833152, rs1199734, rs833152, rs1199734 190423, rs10820814, rs9929889, rs11236294, rs7743622, rs11731978, rs1346490, rs7284476, rs2737220, rs7007200, rs1571892
RESSOURCES ADDITIONNELLES:
Comment votre taille affecte votre santé
Pourquoi les Néerlandais sont-ils si grands?
MISE À JOUR HEBDOMADAIRE: 17 janvier 2020
