Height (Wood, 2014) – Is height genetic?

measuring tape

Nebula Genomics DNA Report for Height

Is height genetic? We created a DNA report based on a study that attempted to answer this question. Below you can see a SAMPLE DNA report. To get your personalized DNA report, purchase our Whole Genome Sequencing!

Sample report on height from Nebula Genomics
Sample variants on height from Nebula Genomics
To learn more about how Nebula Genomics reports genetic variants in the table above, check out the Nebula Research Library Tutorial.

Humans have a variety of heights, from short to tall. Height is largely considered a result of genetics. However, environmental factors, such as nutrition, may also influence the characteristic, making an individual shorter or taller than expected.

Is Height Genetic?

Overall, genetic factors are the most important indication of final adult height, with some experts estimating that about 80% of variations in an individual’s height is a result of DNA. This data was published in 2020 as a collection of genome wide association studies of more than 4 million people

To date, over 700 genetic variants have been discovered to be associated with the characteristic. Most of these contributions from individual genes are small and it is the combination that ultimately results in height. Some of these genes influence cartilage in growth plates, which are involved in lengthening bones as children grow.

Tall and short stature
Human variation in height. Pixabay.

Because so many genes are involved it is difficult to predict how tall a child will be. Generally, children will grow to be about the same height as their parents but different genetic combinations often result in siblings being different heights. Other biological features, such as hormones, may have a larger influence. 

Unlike the combination of genes with small influences, some genetic features have been identified that strongly influence the characteristic. Medline Plus defines some of these genes:

FGFR3: This is a rare genetic mutation involved in the development of bone and brain tissue. Specific mutations in this gene cause almost all cases of achondroplasia, a form of short-limbed dwarfism. The mutations cause this gene to be overly active and interfere with skeletal development.  

FBN1: This gene is involved in making the protein that allows microfibrils to form. These molecules form elastic fibers, which enable the skin, ligaments, and blood vessels to stretch. They also support other structures like bones, nerves, and muscles. 

At least nine FBN1 gene mutations have been identified in people with acromicric dysplasia, which leads to severely short height, short limbs, stiff joints, and distinctive facial features. Additionally, over 1,000 gene mutations in this gene have been associated with Marfan syndrome, which affects connective tissue in the body. These individuals tend to be tall and slender with elongated fingers and toes and other skeletal abnormalities like long bones.

More genes for genetic height

GH1: This gene encodes for a growth hormone protein. Gene mutations can cause isolated growth hormone deficiency, which causes slow growth and short stature. 

EVC: The function of the protein that this gene codes for is unknown. However, it is believed to be involved in normal growth and development. Mutations in this gene cause Ellis-van Creveld syndrome, characterized by dwarfism, abnormal nails and teeth, and heart defects. At least one mutation in this gene has also been associated with Weyers acrofacial dysostosis. This condition is similar, but usually milder, than Ellis-van Creveld syndrome.

GPC3: This gene encodes for a protein involved with cell growth and division. In most cases, it appears to restrict growth although it may have the opposite effect in some parts of the body. Several mutations in this gene may cause Simpson-Golabi-Behmel syndrome, a condition characterized by infants that are larger than normal at birth and continue to grow and gain weight at an accelerated rate. 

Factors Other than Genetic Height

Other factors besides genetics contribute to an individual’s height. These environmental factors are especially important during childhood and adolescence.

Nutrition

Adequate nutrition during childhood tends to be very important for reaching the height dictated by genetics. A healthy, balanced diet will allow your body to develop normally and often maximize your height and stature. On the other hand, a poor diet can affect height by stunting growth and reducing normal development of bones and muscles. 

Nutrition of a mother during pregnancy can also influence genetic height as can factors such as whether the mother smoked or was exposed to hazardous substances.

Socioeconomic status

This factor is often related to nutrition. It has been shown that children in poorer socioeconomic conditions have less access to healthy nutrition and good child and health care. The effect on height can be shorter stature.

Gender

Girls tend to be taller than boys during adolescence as a result of earlier puberty milestones. However, adult men tend to have a taller average height than female adults.

Human height growth
Human height growth in the United States. Wikipedia. CC-CC0 1.0 Universal Public Domain Dedication.

Hormones

Hormones are essential to growth during puberty. Hormonal abnormalities, especially during this time of quick growth, can reduce an individual’s overall height. For example, hypothyroidism can reduce height compared to genetic predisposition. Conditions involving the pituitary gland can also reduce height. 

Interestingly, hormones are controlled by genetics, indicating that there may be an indirect genetic component to those of short stature caused by one of these abnormalities. 

If you liked this article, you should check out our other posts in the Nebula Research Library!