Lung adenocarcinoma (McKay, 2017)

microscope image of chromosomes

STUDY TITLE: Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

SUMMARY: Identification of 6 novel genomic regions associated with lung adenocarcinoma.

OVERVIEW: Lung cancer is a condition in which cells in the lungs divide uncontrollably. Lung adenocarcinoma is a subtype that accounts for ~40% of all lung cancers. It is caused by mutations in mucus-producing glandular cells of the lungs. On average, lung adenocarcinoma tends to grow more slowly than other subtypes of lung cancer. To better understand the genetic basis of this cancer, this study examined the genomes of ~67,000 individuals. The researchers identified 6 new regions associated with lung adenocarcinoma. Half of these regions are located near genes related to telomere length, which shortens with age. Overall, the genetic variants identified help explain 6.7% of the heritability of this cancer.

DID YOU KNOW? The most common type of lung cancer in women is adenocarcinoma. Moreover, adenocarcinoma is least associated with smoking. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

lung adenocarcinoma sample results

LUNG ADENOCARCINOMA-ASSOCIATED VARIANTS: rs7705526, rs77468143, rs13080835, rs115917190, rs4236709, rs1056562, rs885518, rs41309931

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WEEKLY UPDATE: May 12, 2020