SUMMARY: Identification of 6 novel genomic regions associated with lung adenocarcinoma.
OVERVIEW: Lung cancer is a condition in which cells in the lungs divide uncontrollably. Lung adenocarcinoma is a subtype that accounts for ~40% of all lung cancers. It is caused by mutations in mucus-producing glandular cells of the lungs. On average, lung adenocarcinoma tends to grow more slowly than other subtypes of lung cancer. To better understand the genetic basis of this cancer, this study examined the genomes of ~67,000 individuals. The researchers identified 6 new regions associated with lung adenocarcinoma. Half of these regions are located near genes related to telomere length, which shortens with age. Overall, the genetic variants identified help explain 6.7% of the heritability of this cancer.
DID YOU KNOW? The most common type of lung cancer in women is adenocarcinoma. Moreover, adenocarcinoma is least associated with smoking. [SOURCE]
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LUNG ADENOCARCINOMA-ASSOCIATED VARIANTS: rs7705526, rs77468143, rs13080835, rs115917190, rs4236709, rs1056562, rs885518, rs41309931
WEEKLY UPDATE: May 12, 2020