Longevity (Timmers, 2020)

STUDY TITLE: Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

SUMMARY: Identification of 10 genetic variants associated with longevity.

OVERVIEW: Longevity is a trait that is defined as having a longer lifespan than most people. This study specifically defined longevity as living longer than 90% of people. Though factors such as diet and access to health care influence how long an individual may live, genetics also plays a role in longevity. This genome-wide association study examined over 36,000 individuals of European ancestry to determine genetic factors associated with longevity. The study found 10 genetic variants that are linked to the trait, but also parental lifespan and healthspan. The variant with the strongest association (rs429358) is in the APOE gene and is linked to Alzheimer’s disease. This variant alone imparts a ~ 1.7 greater odds of living longer than 90% of people.

DID YOU KNOW? “Blue zones” are locations around the globe where individuals tend to live much longer than average. Okinawa (Japan) and Ikaria (Greece) are two such locations, where a high percentage of inhabitants live long into their 90s. Plant-heavy diets and strong family connections are traits common in many “blue zones”. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

longevity sample results

LONGEVITY-ASSOCIATED VARIANTS: rs429358, rs10455872, rs7859727, rs61905747, rs6511720, rs12830425, rs1159806, rs4783780, rs2643826, rs17499404

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Longevity (Deelen, 2019)

WEEKLY UPDATE: July 28, 2020

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