SUMMARY: Genetic variants in the CD1A gene are associated with an increase of NFL proteins in the blood and a higher risk of Alzheimer’s disease.
DESCRIPTION: Alzheimer’s disease causes a gradual decline in memory and thinking abilities by damaging the nerve cells in the brain. Neurofilament light proteins (NFL) are often used to test for the presence or progress of Alzheimer’s and other neurodegenerative disorders. The genetic contribution leading to increased NFL levels in the blood is not well understood. This study examined 545 non-Hispanic white participants in order to find genetic variants linked to increased blood NFL levels and therefore, to an increased risk of Alzheimer’s. The identified genetic variants were located in the CD1A gene – a gene that plays a role in the immune system.
DID YOU KNOW? Controlling high blood pressure or high cholesterol levels may reduce your risk of Alzheimer’s disease. In addition, being physically and socially active can help prevent this disease. [SOURCE]
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ALZHEIMER’S-ASSOCIATED VARIANTS: rs16840041
WEEKLY UPDATE: July 26, 2019