STUDY TITLE: Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
SUMMARY: Discovery of novel genetic variants associated with luminal B/HER2-negative-like breast cancer.
OVERVIEW: Among women, breast cancer is the second most common type of cancer. In fact, about 13% of women in the United States develop breast cancer during their lifetime. Breast cancer types can be classified by tumor markers, such as the receptors found on the surface of cancer cells. Luminal B/HER2-negative-like breast cancer is a type of breast cancer characterized by cancerous cells originating in the inner, or luminal, cells that line the mammary ducts. This breast cancer type is also characterized by cells growing in response to excess estrogen, but it tends to grow faster and have a worse prognosis than luminal A-like breast cancer. This genome-wide association study examined nearly 266,000 individuals of European ancestry to identify genetic variants associated with different breast cancer types, including luminal B/HER2-negative-like breast cancer. In total, the researchers identified 330 genomic regions associated with breast cancer types and used them to calculate polygenic scores.
DID YOU KNOW? A treatment option for patients with breast cancer is to get a mastectomy, which is the surgical removal of one or both breasts. The first-ever mastectomy was performed almost 200 years ago by a Japanese surgeon. [SOURCE]
SAMPLE RESULTS: Learn more about the Nebula Research Library.
LUMINAL B/HER2-NEGATIVE-ASSOCIATED VARIANTS: rs9712235, rs4602255, rs1375631, rs188092014, rs13256025, rs13277568, rs4742903, rs11652463, rs495367, rs7924772, rs78378222, rs206435, rs6065254, rs17215231, rs612683, rs616488, rs7513707, rs12406858, rs637868, rs11249433, rs111458676, rs11205303, rs12091730, rs2992756, rs35383942, rs7514172, rs2785646, rs2576261, rs11117758, rs11118563, rs72755295, rs4233486, rs114282204, rs707475, rs17426269, rs2151842, rs78425380, rs6746250, rs17625845, rs10164550, rs10179592, rs17726078, rs1550622, rs2356656, rs6743383, rs10197246, rs4442975, rs11693806, rs3791977, rs4676356, rs12472404, rs4322799, rs6756513, rs1036759, rs9882792, rs552647, rs112476261, rs56387622, rs6762558, rs2886671, rs9825432, rs13066793, rs639355, rs62331150, rs56039025, rs28436676, rs62334414, rs13147907, rs10012017, rs17014016, rs17157372, rs335160, rs1428387, rs10069690, rs6860806, rs6596100, rs62329727, rs1432679, rs17611291, rs10074269, rs6864691, rs4868701, rs4866496, rs116095464, rs187108781, rs4613718, rs10941679, rs17343002, rs889310, rs16886165, rs76250845, rs11949391, rs113778879, rs3010266, rs157557, rs332529, rs418053, rs2121348, rs6913578, rs60954078, rs851984, rs6904031, rs910416, rs3819405, rs9364472, rs6940159, rs12211970, rs9358466, rs34196306, rs111342015, rs71559437, rs7800548, rs12706954, rs68056147, rs62485509, rs7971, rs289997, rs74765302, rs13244925, rs17268829, rs4439053, rs111963714, rs62517052, rs12546444, rs13267382, rs62526620, rs35542655, rs12541094, rs7842619, rs12550713, rs10096351, rs1016578, rs7830152, rs66823261, rs1028016, rs310295, rs9693444, rs13365225, rs1511243, rs72658084, rs1533366, rs10816625, rs13294895, rs7848334, rs630965, rs1895062, rs3861871, rs17694493, rs10975870, rs665889, rs10120432, rs10885405, rs12250948, rs9421410, rs45631580, rs45631563, rs10796139, rs7072776, rs10764337, rs2384736, rs10995201, rs6479868, rs111833376, rs719338, rs4980029, rs7125780, rs610437, rs625145, rs7121616, rs7939702, rs11822830, rs10832963, rs4980386, rs4472923, rs7394715, rs10838267, rs77047825, rs12287832, rs10896047, rs35039974, rs661204, rs78540526, rs6597981, rs2454399, rs12422552, rs788458, rs7297051, rs2277339, rs17356907, rs56404467, rs11571833, rs9315973, rs12870942, rs2181965, rs4983544, rs34914085, rs2253012, rs2588809, rs11624333, rs941764, rs78440108, rs144767203, rs187010898, rs4774565, rs8042593, rs35874463, rs8035987, rs2290202, rs34872983, rs75753503, rs11076805, rs35668161, rs4784227, rs55872725, rs6499648, rs7184573, rs28539243, rs12709163, rs7500067, rs12449271, rs79461387, rs150537328, rs11296, rs17881320, rs149370081, rs2787486, rs745570, rs11665269, rs1111207, rs527616, rs8092192, rs72931898, rs9954058, rs9952980, rs117922601, rs56069439, rs10164323, rs56681946, rs4399645, rs1172821, rs1154723, rs6030585, rs13039563, rs16991615, rs2822999, rs2823130, rs2403907, rs4818836, rs9798754, rs17879961, rs5997390, rs34134147, rs132289, rs5750715, rs9611990, rs112855987, rs28512361
Causes of breast cancer (Video)
Subtypes of breast cancer
YOU MAY ALSO BE INTERESTED IN:
Luminal A-like breast cancer (Zhang, 2020)
HER2-enriched-like breast cancer (Zhang, 2020)
Luminal B-like breast cancer (Zhang, 2020)
Triple-negative breast cancer (Zhang, 2020)
Breast cancer (Shu, 2020)
WEEKLY UPDATE: June 2, 2020