SUMMARY: Discovery of novel genetic variants associated with HER2-enriched-like breast cancer.
OVERVIEW: Breasts are complex structures with multiple cell types which can give rise to multiple types of cancer. Breast cancers are classified by what receptors cancer cells have on the outside. This classification is helpful for predicting outcomes and effective treatments. Breast cancers that use the human epidermal growth factor 2 receptor (HER2+) make up 15-30% of all breast cancers. HER2+ breast cancers are historically associated with poor prognosis and an increased recurrence, but there are now new drugs that specifically target the HER2 receptor and improve survival. HER2-enriched-like cancers have the HER2 receptor but do not have other hormone receptors like receptors for estrogen or progesterone. This genome-wide association study examined nearly 266,000 individuals of European ancestry to identify genetic variants associated with different breast cancer types, including HER2-enriched-like cancers. In total, the researchers identified 330 genomic regions associated with breast cancer types and used them to calculate polygenic scores.
DID YOU KNOW? Modern therapies are able to specifically target cells that express HER2. This has dramatically increased the survival rate for patients with HER2+ breast cancer. [SOURCE]
SAMPLE RESULTS: Learn more about the Nebula Research Library.
HER2-ENRICHED BREAST CANCER-ASSOCIATED VARIANTS: rs9712235, rs4602255, rs188092014, rs13256025, rs13277568, rs11652463, rs495367, rs7924772, rs78378222, rs206435, rs17215231, rs612683, rs616488, rs7513707, rs12406858, rs637868, rs11249433, rs111458676, rs11205303, rs12091730, rs2992756, rs35383942, rs6686987, rs7514172, rs2785646, rs2576261, rs11118563, rs72755295, rs4233486, rs114282204, rs707475, rs2151842, rs78425380, rs6746250, rs17625845, rs10164550, rs10179592, rs17726078, rs1550622, rs2356656, rs6743383, rs10197246, rs4442975, rs11693806, rs3791977, rs4676356, rs6725517, rs12472404, rs4322799, rs1036759, rs9882792, rs552647, rs112476261, rs17838698, rs56387622, rs6762558, rs2886671, rs9825432, rs13066793, rs639355, rs62331150, rs56039025, rs13147907, rs10012017, rs17014016, rs17157372, rs335160, rs1428387, rs10069690, rs6860806, rs62329727, rs1432679, rs17611291, rs10074269, rs6864691, rs4868701, rs116095464, rs187108781, rs4613718, rs10941679, rs17343002, rs889310, rs16886165, rs76250845, rs11949391, rs113778879, rs3010266, rs157557, rs418053, rs2121348, rs6913578, rs60954078, rs851984, rs6904031, rs910416, rs3819405, rs9364472, rs6940159, rs12211970, rs9358466, rs34196306, rs111342015, rs73754909, rs71559437, rs7800548, rs12706954, rs68056147, rs62485509, rs7971, rs289997, rs74765302, rs13244925, rs17268829, rs4439053, rs111963714, rs62517052, rs12546444, rs13267382, rs62526620, rs35542655, rs12541094, rs7842619, rs12550713, rs10096351, rs1016578, rs7830152, rs66823261, rs1028016, rs310295, rs9693444, rs13365225, rs1511243, rs72658084, rs1533366, rs10816625, rs13294895, rs7848334, rs630965, rs1895062, rs3861871, rs17694493, rs4880038, rs10975870, rs10120432, rs10885405, rs12250948, rs45631580, rs45631563, rs10796139, rs7072776, rs10764337, rs2384736, rs10995201, rs6479868, rs111833376, rs719338, rs4980029, rs7125780, rs610437, rs625145, rs7121616, rs7939702, rs11822830, rs10832963, rs4980386, rs4472923, rs7394715, rs10838267, rs77047825, rs12287832, rs10896047, rs35039974, rs661204, rs78540526, rs6597981, rs2454399, rs12422552, rs788458, rs7297051, rs2277339, rs17356907, rs56404467, rs11571833, rs9315973, rs12870942, rs2181965, rs4983544, rs34914085, rs2253012, rs2588809, rs11624333, rs941764, rs78440108, rs144767203, rs187010898, rs4774565, rs8042593, rs35874463, rs8035987, rs2290202, rs34872983, rs75753503, rs11076805, rs35668161, rs4784227, rs55872725, rs6499648, rs7184573, rs28539243, rs12709163, rs7500067, rs9931038, rs12449271, rs79461387, rs150537328, rs11296, rs17881320, rs149370081, rs2787486, rs745570, rs16976596, rs11665269, rs1111207, rs527616, rs8092192, rs72931898, rs9954058, rs9952980, rs117922601, rs56069439, rs10164323, rs56681946, rs4399645, rs1172821, rs1154723, rs6030585, rs13039563, rs16991615, rs2822999, rs2823130, rs2403907, rs4818836, rs9798754, rs17879961, rs5997390, rs34134147, rs132289, rs5750715, rs9611990, rs112855987, rs28512361
ADDITIONAL RESOURCES:
HER2 positive breast cancer: everything you must know (Video)
HER2 status
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WEEKLY UPDATE: June 2, 2020
