Osteoarthritis (arcOGEN Consortium, 2012)

Osteoarthritis, man stretching on beach

STUDY TITLE: Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

SUMMARY: A genetic variant in the GNL3 gene may increase the risk of osteoarthritis.

DESCRIPTION:  Osteoarthritis is the most common form of arthritis worldwide. It is also called “wear and tear” arthritis and occurs when the cartilage between joints breaks down, leading to pain, stiffness, and swelling. This condition is known to have a heritable component that contributes to risk, but the genetic factors are not well defined. This study examined 18,419 individuals of European descent and identified a variant in the GNL3 gene that is associated with the condition. The GNL3 protein, also known as nucleostemin, is essential for regulating the cell cycle in stem cells. Although the exact relationship between nucleostemin and cartilage cells is unknown, studies have shown that increased nucleostemin protein levels are found in osteoarthritis patients. This suggests that the GNL3 gene may be important in the progression of this condition.

DID YOU KNOW? Low-impact exercise that includes strength training and stretching with aerobic exercise may improve joint health and help prevent osteoarthritis. Maintaining a proper weight and resting injured or swollen joints can also reduce your risk for osteoarthritis. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Osteoarthritis sample results.

ANALYZED VARIANTS: rs143383, rs6976, rs4836732, rs9350591, rs10492367, rs835487, rs11842874

Chondrocyte (cartilage cells)

WEEKLY UPDATE: July 23, 2019