STUDY TITLE: Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
SUMMARY: Identification of 6 genetic variants associated with fat consumption.
OVERVIEW: Fats are essential macronutrients that serve as structural building blocks in the body. More specifically, the membranes of our cells are mostly made of fat. Moreover, fats also allow certain vitamins to be absorbed by the intestines. On average, adults consume 44 to 77 grams of fat per day. To identify genetic variants that are associated with fat consumption, this genome-wide association study examined the genomes of over 260,000 individuals of European ancestry. The study identified 6 genetic variants associated with fat consumption. One of these, the rs429358 variant in the APOE gene and has been previously linked to Alzheimer’s disease risk. Specifically, the rs429358 T allele is associated with increased fat consumption and decreased Alzheimer’s risk. Fat consumption was also found to be negatively correlated with body mass index (BMI) and physical activity.
DID YOU KNOW? Fat has more than twice as many calories per gram as carbohydrates and proteins. [SOURCE]
SAMPLE RESULTS: Learn more about the Nebula Research Library.
FAT CONSUMPTION-ASSOCIATED VARIANTS: rs1229984, rs33988101, rs9927317, rs7012814, rs429358, rs57193069
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WEEKLY UPDATE: May 26, 2020