Glaucoma (MacGregor, 2018)

Old male eye glaucoma

STUDY TITLE: Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma

SUMMARY: Identification of over 24 genetic variants that correlate with the development of glaucoma.

DESCRIPTION: Glaucoma is one of the leading causes of blindness in older adults, though it can occur at any age. It develops when the optic nerve that connects the eye to the brain becomes damaged, often as a result of increased pressure within the eye. One method of halting glaucoma progression is to decrease that pressure. This genome-wide association study of over 130,000 participants of European descent identified 24 genetic variants associated with increased intraocular pressure and the risk of developing this condition. Two of the variants are located near genes that play a role in development and function of the optic nerve (CDKN2B and SIX6).

DID YOU KNOW? While damage from this condition can’t be reversed, early detection can help slow the progression of vision loss. Regular eye exams can detect increased intraocular pressure before the vision becomes impaired. [SOURCE]

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GLAUCOMA-ASSOCIATED VARIANTS: rs7518099, rs944801, rs2472493, rs2093210, rs9913911, rs28795989, rs945686, rs2745572, rs9284802, rs58073046, rs12699251, rs10505100, rs2024211, rs9853115, rs61394862, rs2935057, rs2073006, rs61861119, rs8141433, rs4141671, rs73174345, rs1013278, rs7924522, rs11710139

Intraocular (eye) pressure
What is this disease?

WEEKLY UPDATE: October 24, 2019