Thyroid stimulating hormone levels (Zhou, 2020)

STUDY TITLE: GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

SUMMARY: Identification of 28 novel regions associated with thyroid stimulating hormone levels.

OVERVIEW: The thyroid is a butterfly-shaped gland located at the front of the neck. It plays a critical role in controlling the body’s metabolism by regulating how fast we burn calories and many other things. The thyroid itself is controlled by the pituitary gland, which is located in the brain, and releases thyroid stimulating hormone (TSH) that spurs the thyroid into action. TSH levels are commonly used to diagnose a variety of thyroid disorders, including hypothyroidism, hyperthyroidism, and thyroid cancer. This genome-wide association study examined nearly 120,000 individuals of European ancestry to better understand how genetics may influence TSH levels. The study identified 74 regions in the genome that appear to associate with TSH levels, 28 of which are newly discovered. One of the regions harbors the TSHR gene, which acts as a receptor for the thyroid stimulating hormone. The study also found that genetic predisposition to higher TSH levels is associated with a reduced risk of thyroid cancer.

DID YOU KNOW? Women are between 5-8x more likely to develop disorders of the thyroid than men. On average, 1 in 8 women will be afflicted with a thyroid disorder during their lifetime. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

tsh level sample results

TSH LEVEL-ASSOCIATED VARIANTS: rs1479567, rs2983511, rs11732089, rs1317983, rs2928167, rs13020935, rs58722186, rs12138950, rs9381266, rs334725, rs17477923, rs17020122, rs6575306, rs12284404, rs139352934, rs12027702, rs10748781, rs73234178, rs925488, rs4804416, rs1348005, rs121908872, rs116909374, rs10814915, rs61938844, rs1203949, rs8020969, rs118039499, rs1042678, rs59381142, rs310755, rs13100823, rs7873463, rs59148743, rs12893151, rs117764941, rs56009477, rs11156905, rs12942923, rs6724073, rs544873, rs10186921, rs9497965, rs2242602, rs179256, rs4445669, rs7318607, rs141751376, rs12590163, rs1265091, rs28133, rs34046483, rs7966590, rs9678281, rs4933466, rs11926459, rs1157994, rs10415188, rs11592436, rs700750, rs191633940, rs116956554, rs2993047, rs11583886, rs1045774, rs1045476, rs6721104, rs35587648, rs3104389, rs751171, rs6717283, 10735341, rs145153320, rs62174422, rs1801690, rs2979181, rs9298749, rs3184504, rs72978712, rs12743883, rs7083359, rs12029562, rs546738875, rs6989821, rs6085658, rs77994712, rs4571283, rs1373851, rs3731890, rs4719486, rs4393429, rs10421676, rs10878986, rs74888443, rs30233, rs9865818, rs72682433, rs5997969

How your thyroid works

Autoimmune thyroid disease (Saevarsdottir, 2020)
Thyroid cancer (Liyanarachchi, 2020)
Thyroid Cancer (Gudmundsson, 2017)

WEEKLY UPDATE: August 18, 2020