Tourette’s syndrome (Yu, 2019)

STUDY TITLE: Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

SUMMARY: Discovery of multiple genetic variants associated with Tourette’s Syndrome.

OVERVIEW: Tourette’s syndrome is a disorder of the nervous system characterized by uncontrollable movements or sounds that are known as tics. It affects about 1 out of every 150 people to varying degrees. Tourette’s syndrome is known to be highly heritable, with up to 80% of the disease risk being inherited from the parents. This genome-wide association study sought to identify genetic variants associated with Tourette’s Syndrome by examining over 20,000 individuals of European ancestry. One of the top variants is located in the FLT3 gene, which encodes a receptor protein that is believed to play a role in immune system functions. The authors also report 9 other genetic variants that are significantly associated with Tourette’s Syndrome.

DID YOU KNOW? Tourette’s Syndrome is typically diagnosed early in life. Though it is a chronic condition, many affected individuals experience a peak in symptoms in the teenage years followed by a gradual improvement through adulthood. [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

tourettes syndrome sample results

TOURETTE’S-ASSOCIATED VARIANTS: rs2504235, rs191044310, rs13407215, rs2708146, rs1906252, rs12459560, rs117648881, rs6670211, rs72853320, rs73205493

Tourette syndrome: What makes people tic? (Video)
What is Tourette?

Tremors (Müller, 2016)
Epilepsy (ILAEC, 2014)

WEEKLY UPDATE: July 11, 2020