Celiac Disease (Dubois, 2010)

Photo of gluten free salad bowl

STUDY TITLE: Multiple common variants for celiac disease influencing immune gene expression

SUMMARY: Discovery of 13 new genomic regions associated with celiac disease.

OVERVIEW:  Celiac disease is characterized by an inability to eat gluten, a protein found in wheat and some other types of grain. The disorder is an autoimmune disease, in which the body’s own immune system attacks the intestines in the presence of gluten. As a result, this can lead to pain, diarrhea, and other digestive problems. This genome-wide study examined over 25,000 individuals of European descent to better under the genetic underpinnings of susceptibility to celiac disease. The researchers identified 13 novel genetic loci potentially linked to the risk of the disease. Many of the variants are near genes that play a role in the immune system, especially in the function of T cells, that normally kill cells that are infected by viruses or are cancerous.

DID YOU KNOW? While a gluten-free diet may sound challenging to adhere to, there are many foods that are naturally gluten-free. For example, grains such as quinoa, oats, and corn don’t contain gluten. Other common gluten-free foods are soy, rice, and potato! [SOURCE]

SAMPLE RESULTS: Learn more about the Nebula Research Library.

Celiac disease sample results

CELIAC DISEASE-ASSOCIATED VARIANTS: rs2187668, rs1464510, rs17810546, rs13151961, rs653178, rs2327832, rs2816316, rs13098911, rs11221332, rs917997, rs1738074, rs802734, rs13003464, rs13010713, rs10903122, rs1893217, rs10806425, rs1250552, rs4819388, rs13314993, rs3748816, rs9792269, rs296547, rs4675374, rs17035378, rs11712165, rs12928822

Gluten and Celiac Disease (Video)

WEEKLY UPDATE: February 15, 2020