Patients Choice Direct review – At-home pharmacogenetics?

Patients Choice Review Summary

Patients Choice Direct is an at-home pharmacogenetics testing company. Learn more in our Patients Choice Direct review!

Fiyin Ebemidayo, B.S.

patients choice direct testing kit


Patients Choice Direct is an at-home testing company for pharmacogenetics. Patients can perform their test and receive the results without a trip to the doctor’s office. However, a physician must interpret the results and put any recommendations into action.
The price is on par with other types of these tests. While patients can use insurance, it tends to take longer.


7 Facts from our Patient Choice Direct Review

  1. Location: Indianapolis, IN, USA
  2. Products: A pharmacogenetics (PGx) test that analyzes 35 genes and how they help metabolize around 180 medications
  3. Cost: $299
  4. Reports: The test results are delivered to a HIPAA-compliant patient portal for the patient and their healthcare provider to review
  5. How it works: Customers collect their sample and send it back to the laboratory using a pre-paid return label. Results are typically available within 7-14 days after the sample arrives at the lab 
  6. Counseling available: No
  7. Other Products: Nebula Genomics offers 30X Whole Genome Sequencing that decodes 100% of your DNA and gives reports on diet and much more!

This review is written with the intent to be as unbiased as possible. However, it represents the opinion of an individual reviewer and is therefore subjective. Furthermore, at Nebula Genomics we seek to educate the public about the benefits of Whole Genome Sequencing. Information about our Whole Genome Sequencing DNA test is therefore incorporated into the review.

June 20, 2023

Pros and Cons


  • At-home pharmacogenetics
  • In-house laboratory testing 
  • HIPAA-compliant patient portal for secure and confidential access to results


  • Currently only offering pharmacogenetics
  • Results must be interpreted and put into action by a physician
  • Only covered by insurance if a medical necessity
  • Going through insurance takes longer to process than self-paying


Patients Choice Direct offers a pharmacogenetics (PGx) test that analyzes your unique genetic makeup to determine how your body metabolizes medications. It provides insight into 35 genes and their impact on around 180 medications.

The results include the most common medications for various conditions. Patients with chronic conditions, on multiple medications, a history of adverse drug reactions, or starting a new treatment regimen may benefit most from this test.

Patients Choice Directs homepage
Patients Choice Directs homepage

Unlike other pharmacogenetic tests, customers can order online and receive the kit at home. They do not need to order through a physician. However, the website notes that while patients will access their results online, only a physician should interpret them. Patients should never change medications without approval by their doctor. 

Patients Choice Direct has operated an in-house laboratory since 2013 to ensure faster and more accurate results, with a CLIA Certification and CAP Accreditation. The results are delivered to your HIPAA-compliant patient portal for review with your healthcare provider.

Are you interested in a test that decodes 100% of your DNA in addition to the few genes for pharmacogenetics? Nebula Genomics offers Whole Genome Sequencing! This is a complete DNA test that decodes all 20,000 genes and regulatory genomic regions. Click here to learn more!

The Science Behind Patients Choice Direct

Pharmacogenetic testing analyzes a patient’s DNA to identify genetic variations affecting drug metabolism. By understanding a patient’s genetic profile, healthcare professionals can better predict how they will respond to certain medications and adjust the type and dosage of treatment plans accordingly. For patients, this could mean lower overall healthcare costs and less trial-and-error in finding medications. 

This analysis is a rapidly growing field expected to become a standard part of personalized medicine. 

Patients Choice Direct uses innovative molecular diagnostics in their in-house laboratory to process pharmacogenetic kits accurately, providing patients with faster results and greater peace of mind.

Review of the Patients Choice Direct Pharmacogenetic Test

The pharmacogenetic (PGx) kit is a one-time test that evaluates your unique genetic makeup to understand better how your body responds to and metabolizes certain medications.

Patients Choice Direct Pharmacogentics Test
Patients Choice Direct Pharmacogenetics Test

People with certain conditions may find this test particularly useful for honing in on the most effective medication at the appropriate dose. This includes those with cardiovascular disease, diabetes, mental health conditions, multiple sclerosis, and pain management. 

The 35 genes analyzed focus on how people may respond differently to medications.  For example, some people have genetic variants that cause them to metabolize certain medications slowly. Slow metobolizers tend to have these substances build up, causing a standard dose to be too high. On the other hand, fast metabolizers have the medications go through their bodies too quickly potentially suggesting a higher dose is needed.

Overall, an individual patient may need normal dose, lower dose, higher dose, or alternative medication.

The table below lists the genes covered in the analysis.


Review of Taking a Patients Choice Direct Test

With test kits delivered right to your doorstep, patients can select their preferred test and pay online, making it an affordable alternative to the typical physician-ordered process.

Once ordered, the test kit is shipped to the patient’s home. The kit includes everything needed to collect and return your sample to the laboratory.

Taking a Patients Choice Direct Test
Taking a Patients Choice Direct Test

Customers collect their sample using the provided cheek swabs and return it using the pre-paid return label to ship it back using FedEx.

Finally, you receive your results in your HIPAA-compliant patient portal. This makes it easy for you and your healthcare provider to review the results at your convenience.

Review of Patients Choice Direct Cost

The regular price for a Patients Choice Direct’s Pharmacogenetic (PGx) test is $299, which includes tax.

The test is HSA/FSA eligible. 

Additionally, patients may be elegible to use their insurance. Medicare, Medicaid, or commercial insurance may pay when there is a medical neccesity.

Using insurance will typically delay shipping since their is an extra step that needs to be completed by a physician. In brief, the patient completes an online form and the company contacts the listed physician. Then, the physician completes the necessary information in an online portal.

Review of a Patients Choice Direct Report

The Patients Choice Direct report provides detailed genetic information, allowing healthcare providers to make informed treatment decisions. The report includes genetic information on 32 enzymes, two transporters, and one receptor, including well-known genes like CYP2D6 and HLA-B. 

The report uses a color-coded system to describe the patient’s metabolism type for each medication. 

  • Red = poor metabolizer. Body breaks drug down slowly, increasing risk of side effects
  • Yellow = intermediate metabolizer. Body breaks drug down slower than usual, slight increase in side effect risk
  • Green = normal metabolizer
  • Blue = rapid metabolizer. Body breads drug down too quickly, reducing effectiveness
Color-coded system
Patients Choice Direct color-coded system

A patient’s current medications will be listed in the report. Patients Choice Direct uses the DNA analysis to determine how the patients metabolizes these medications and provides recommendations for physicians.

Sample of current medications list
Sample of current medications list

In the sample above, the patient is taking Coreg (Carvedilol), Metoprolol (Lopressor®), and Simvastatin (Zocor®) for cardiovascular disease. According to their genes, they should take Coreg in the standard dose. However, they may want to consider a lower dose of Metoprolol and an alternative to Simvastatin since they are metabolized slower in this patient. 

The report also includes a list of all potentially impacted medications divided into categories of “Standard Precautions”, “Use with Caution”, and “Consider alternatives”.

Review of Patients Choice Direct Privacy Policy

The privacy policy of Patients Choice Direct states that it collects personal information, including device and order information, from individuals who visit or make purchases from the website. It collects this information to provide services and fulfill contracts with its customers.

The company can share health in a number of venues. Markedly, it can share health information with professionals who are treating you, to run its organization and bill for services, when needed to help with public health and safety, for research, and to comply with the law.

Other Patients Choice Direct Reviews

There are no reviews on the company’s website. Also, the company has no reviews on third-party sites such as Trustpilot or Amazon.

Nebula Genomics

Patients Choice Direct offers a single test kit on pharmacogenetics shipped directly to the patient. Results are usually available within two weeks and should be shared with a healthcare professional. 

On the other hand, Nebula Genomics covers much more than 35 genes. We provide a comprehensive test highlighting predispositions related to diet, fitness, disease, and much more. With 30x Whole-Genome Sequencing, Nebula sequences 100% of your DNA to get to the root cause of every biological inclination. This includes the same genes and variants analyzed in things like pharmacogenetic testing.

The test is incredibly accurate and includes other additions, including ancestry reporting and genome exploration tools. Regularly updated reports ensure that you will not miss the latest genetic research. 

Nebula is not a diagnostic test, but the results are of the highest quality and can be used in consultation with health care professionals.

For only $299 or less, customers will get access to their entire genome, allowing them to continue to ask more questions as more research is conducted.

Patients Choice Direct vs. Nebula Genomics

Patients Choice DirectNebula Genomics
Testing methodCheek swabSaliva sample
Report35 genes to analyze about 180 medicationsSequences of all 20,000 genes and regulatory regions
ResultsInterpreted by a healthcare professionalGenetic predispositions that can be interpreted by the customer
Ancestry reportingNoPerforms deep ancestry reporting with the complete Y chromosome and mtDNA sequencing
CounselingNoNo, but data is of the highest quality and can be used by physicians and genetic counselors
Cost$299$0, $99, $299

Did you like our Patients Choice review? You can read more reviews on our blog and check out our complete guide to the best DNA test kit and other home tests.

If you are interested in pharmacogenetic tests you may want to also check out these other companies:

  • 4U Health (allergies, sensitivities, pharmacogenetics, and drug tests)
  • 24Genetics (various tests for health, ancestry, sports, skin, pharmacogenomics, WES, and WGS)
  • ClarityX DNA (predicted reactions for up to 265+ common medications)
  • GeneSight (clinical genomic test for psychotropics)
  • Genomind (pharmacogenomic testing for mental health treatment)
  • GeneTrait Laboratories (pharmacogenetics for a variety of health conditions)
  • Inagene (pharmacogenetic testing for mental health and other condition)
  • Incite Health (pharmacogenetics for mental health treatments)
  • myDNA (personalized medications available in Canada, Australia, and New Zealand)
  • Veritas Genetics (disease risks, carrier screenings, and pharmacogenetics)

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