Lipozene review – Is soluble fiber a fix for weight loss?

Lipozene Review Summary

Lipozene uses water-soluble fiber in pill form to offer a weight loss supplement. Learn more in our Lipozene review!

Fiyin Ebemidayo



Lipozene is an affordable supplement that many people have reported as an effective weight loss tool. However, the evidence to support the drastic claims is minimal, and some customers claim it is not effective.


7 Facts from our Lipozene Review

This review is written with the intent to be as unbiased as possible. However, it represents the opinion of an individual reviewer and is therefore subjective. Furthermore, at Nebula Genomics we seek to educate the public about the benefits of Whole Genome Sequencing. Information about our Whole Genome Sequencing DNA test is therefore incorporated into the review.

  1. Location: Groveport, Ohio
  2. Products: Lipozene and MetaboUP Plus
  3. Costs: $29.95 per bottle of 60 weight loss capsules plus one extra bottle for free and a bottle of MetaboUP Plus
  4. Reports: None since the service does not include testing of any kind
  5. How to order: Customers can order products online through the official website or Amazon 
  6. How it works: Customers take 2 Lipozene pills up to 3 times a day. The active fiber ingredient is intended to make you feel full
  7. Complementary Products: Nebula Genomics (Whole Genome Sequencing with regularly updated reports (incl. diet), data exploration tools, and advanced ancestry reporting)

June 8, 2023

Pros and Cons


  • The pills are plant-based, caffeine-free, GMO-free, soy-free, and gluten-free
  • They are affordable


  • Customers have complained about the deceptive nature of the claims about the pills
  • A lawsuit settlement was reached against misleading claims of the company
  • There has not been strong evidence to link the active ingredient in the capsules with weight loss


What is Lipozene? Lipozene is a dietary supplement company that makes the Lipozene weight-loss capsules. It is currently led by CEO Thomas Barker. The company, also copyrighted as “Obesity Research Institute (ORI),” is run by Henny den Uijl and Sandra den Uijl.

Lipozene homepage
Lipozene homepage

Lipozene’s active ingredient is glucomannan, a Konjac root (Amorphophallus konjac) extract, also known as elephant yam. It’s also the main ingredient in shirataki noodles. The company claims that the water-soluble, fermentable dietary fiber has the ability to promote weight loss and increase energy levels. Additional clinical studies have shown that fiber has other health benefits, like reducing fats, cholesterol, and blood sugar levels. 

However, the company has had its fair share of controversies since its inception in 2003. In 2020, the Obesity Research Institute and Continuity Products had to settle a $4.6 million lawsuit. The plaintiffs accused Lipozene of wrongly advertising the product as a “weight-loss breakthrough” that would “get rid of pounds of body fat.” 

The lawsuit paid every client who purchased the diet pills between August 10, 2012, and October 28, 2019. The CEOs of Obesity Research Institute and Continuity Products, Henny den Uijl and Sandra den Uijl, denied any wrongdoing. However, they agreed to change the marketing statements for the product.

Before you consider taking dietary supplements for weight loss, you should sequence your genome! Nebula Genomics offers Whole Genome Sequencing. This is a complete DNA test that decodes 100% of your DNA.

WGS will enable you to learn more about your ancestry and other health benefits than any other DNA test! Click here to learn more!

Review of Lipozene Science: A fiber to help enhance weight loss

Lipozene is a weight loss supplement and appetite suppressant that claims to help its users lose and maintain weight through a pill that contains glucomannan, a water-soluble fiber that has been clinically proven to help reduce weight.

A Konjac plant
The active ingredient in Lipozene is extracted from the Konjac plant (Amorphophallus konjac). KENPEI via Wikipedia. CC-Attribution-Share Alike 3.0 Unported

How does Lipozene work? This incredible fiber can expand 200x its size (by weight) when in water. Once Lipozene capsules dissolve in the stomach, the proprietary fiber’s ability to absorb water is activated, creating a feeling of fullness that can last for hours. In this way, it tends to make the user feel less hungry and consume fewer food calories. 

The company cites a study on its website in which two groups took the Lipozene drug and a placebo. It claimed the group that took the drug lost 4X more weight than the group with the placebo. It also stated that 78% of the weight lost was pure fat.

However, this study was sponsored by the company and hasn’t been published in any peer-reviewed journal. So its credibility is quite questionable.

At the bottom of the website, the company states that the people involved in the study were not given specific instructions regarding their physical activity and eating habits. This means a few of them could have been into other weight-loss activities like workouts. These suggestions have made quite a few consumers and health experts question the credibility of the weight-loss company claims. 

Other evidence

Some scientific studies have shown that glucomannan fiber (the active ingredient in Lipozene), has short-term effects on weight loss but is not beneficial in the long term. Due to numerous clinical trials not being able to ascertain the fact about glucomannan’s relationship with weight loss, the National Institute of Health (NIH) concluded that the active ingredient has little to no effect on reducing body weight.

Other peer-reviewed studies showed limited or even no promotion of weight loss with glucomannan supplements. Because repeated clinical trials have not been able to prove that the ingredient glucomannan causes significant weight loss, the National Institutes of Health (NIH) has determined that glucomannan has “little to no effect on body weight.”

Statements have not been evaluated by the Food and Drug Administration (FDA), this product is not intended to diagnose, treat, cure, or prevent any disease.

Lipozene Review

How to purchase Lipozene

You could get the capsules either off the Lipozene website or from Amazon. However, it sells the 60-count capsule bottle and an extra bottle of the same quantity for $29.95 on the website. On Amazon, due to the different independent sellers, the prices vary depending on the quantity of the bottles (30- and 60-count). When you ship from the website, there’s a $1.35 processing fee for every purchase made.

Lipozene ordering page
Lipozene ordering page

How to use Lipozene

Is taking Lipozene safe? The recommended dose is two capsules, 30 minutes before eating, three times a day with a glass of water. The company claims the drug has no side effects. However, the NIH warns of some Lipozene side effects like flatulence, loose stools, diarrhea, etc.

Directions for taking Lipozene
Directions for taking Lipozene

Specifically, customers should take two capsules with at least 8 ounces of water 30 minutes before each meal. The product can be taken up to 3 times a day.

Review of Lipozene Cost

The most affordable way to get the product is from the official website, On Amazon, a number of independent sellers offer Lipozene, but it doesn’t have an official store on the third-party marketplace. When you buy from most vendors on Amazon, you might not get the free shipping and free MetaboUP Plus bottle that comes with your purchase when bought from the website.

ORI claims on the website that there’s a money-back guarantee if you do not notice any changes after using the product for 30 days. However, to qualify for this money-back guarantee, you have to lodge your complaint within 30 days. Also, this money-back guarantee is only valid after you get a validation number from the company.

Lipozene Privacy Review

The company divides the information it collects from its customers into personal and non-personal information.

Examples of personal information are name, physical address, email, telephone number, age range, birth date, gender, etc. Lipozene could also collect non-personal information like the browser type, operating system, IP address, and domain name from which the customer accessed the site. 

Lipozene claims to use personal information collected from you for any of the following purposes:

  1. Fulfill product orders and requests for information
  2. To contact you when necessary (e.g., to respond to inquiries)
  3. To send information, promotional materials, and newsletters, etc.

It also notes that it may sell, share, or license your information with a third party in connection with its marketing efforts. However, it claims all third-party companies are PCI-compliant.

Other Lipozene Reviews

With over 1,000 customer reviews on Amazon, these products have an average rating of 3.0 and 3.6 for the 30- and 60-capsule bottle respectively.

Does Lipozene work? While a few users commend the supplement for helping them lose weight and burn fat while they ate less, other Lipozene complaints do not notice any effect on their weight. 

The most common causes for negative reviews include not losing weight, bottles not having the correct amount of pills, and similar logistical complaints.

Lipozene in the News

Lipozene pays off $4.6 million class action lawsuits. The settlement resolves allegations that the company marketed false claims about its weight loss pills and products. On December 4, 2020, people started receiving checks in the mail worth up to $60 from the Lipozene Weight Loss Pills Class Action Settlement.

Nebula Genomics

In some cases, your body’s genetic code may explain why some supplements work better than others. Characteristics like thinness, BMI, and XX can all be associated with genetic variants and may affect how weight loss supplements affect you. So, before trying that next supplement, why not take our 30X Whole Genome Sequencing DNA testing kit to know the weight tendencies embedded in your genome? 

While most DNA tests decode only 0.02% of your DNA, Nebula decodes 100% of your genome. With this significant difference between the DNA we test and other DNA tests, the data we provide is 10,000 times more than other DNA tests such as 23andMe and AncestryDNA. 

Our test provides full ancestry DNA reporting alongside Y chromosome and mtDNA sequencing, which we offer in collaboration with Family Tree DNA. Apart from this, our test will also keep you updated about the latest happenings in the genetic world, thanks to our weekly updates.

Lastly, we know how much our customers value their privacy. This is why we treat your personal information divulged on our website with the utmost importance. Using a combination of blockchain-type protection and privacy computing, your data remains inaccessible to anyone, even to us at Nebula. 

Other companies

If you’re interested in weight loss, you may want to check out programs like Noom, Nutrisystem, Beyond Body, Optavia, and Yoga Burn.

Did you know you can test your metabolism at home? Learn more in our article about metabolism tests at home.

Other supplements you may be interested in include:

Weight loss:

  • Athletic Greens (foundational nutrition powder)
  • Bio X4 (probiotic weight management supplement)
  • Contrave (prescription weight loss pills)
  • Goli Nutrition (apple cider vinegar gummies)
  • Hydroxycut (weight loss supplements)
  • Iaso Tea (a tea for cleaning and weight loss)
  • Ka’Chava (meal replacement shake)
  • Leptitox (supplement to increase leptin and induce quick weight loss)
  • Resurge (deep sleep supplement for weight loss)
  • Rootine (personalized supplement and vitamins based on DNA test)

Did you like our Lipozene review? You can read more reviews on our blog and check out our complete guide to the best DNA test kit and other home tests.

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