Rootine Review – Is Personalized Nutrient Formula The Best?

Rootine Review Summary

Rootine offers DNA and blood tests to help develop personalized supplements unique to the customer. Learn more in our Rootine review!

Fiyin Ebemidayo

Rootine packet


Rootine is a positively reviewed vitamin company that provides customers personalized vitamins and certain nutrients based on their DNA. It can be expensive without already having raw DNA results.


7 Facts from our Rootine Review

  1. Location: Nashville, Tennessee, United States
  2. Product: Rootine offers unique Nutrient Formula based on science and genetic composition 
  3. Costs: The nutrigenetic DNA test costs $115-$125. You can also get a 90-day supply of Rootine vitamins at $2.33/ day, billed at $69.99/month for three months 
  4. Data upload options: 23andMe, AncestryDNA, MyHeritage, Genos, FamilyTreeDNA, and physician-ordered blood panels for free
  5. Reports: Reports provide comprehensive information about your nutrient requirements. They also reveal information about nutrients you may lack in your body system. For example, the reports tell if your body needs more calcium for bone health, more minerals for detoxification, more antioxidants to protect against cell damage, etc.
  6. Privacy: Being a medically licensed genetics lab, it is bound by strict medical data privacy. Therefore, it won’t share or sell your data 
  7. Complementary Products: Nebula Genomics (Whole Genome Sequencing with weekly updated reports (incl. diet), data exploration tools, and advanced ancestry reporting)

This review is written with the intent to be as unbiased as possible. However, it represents the opinion of an individual reviewer and is therefore subjective. Furthermore, at Nebula Genomics we seek to educate the public about the benefits of Whole Genome Sequencing. Information about our Whole Genome Sequencing DNA test is therefore incorporated into the review.

May 11, 2023

Pros and Cons


  • Unique nutrients based on DNA, blood, lifestyle, and health data 
  • Precision dosing 
  • Research proven nutrients 
  • No nausea, slow-release 
  • Premium raw nutrients


  • If you don’t have a DNA result, you need to first spend on tests before getting the required nutrients recommendations
  • Can be expensive (up to $60 per month)
  • For best results, semi-regular blood work is necessary to keep up with your changing biology 


Rootine is a company that provides nutrient packs to its customers and customizes vitamins tailored to individuals. To this end, it examines your genetic makeup to identify your particular nutrient needs and help you achieve health goals. For example, the test will reveal if there is too much of a specific nutrient in your body or if there’s a deficiency. 

The company started in 2018 and has since been offering personalized nutrition solutions. It provides this service by analyzing both the user’s DNA and blood data. This approach allows for more tailored vitamin regimens. 

This company doesn’t believe in the one-size-fits-all approach when it comes to nutritional supplements. Instead, it works based on the scientifically proven belief that every individual is unique in their respective DNA; therefore, their nutrient needs will be unique.

A table comparing Rootine with similar companies
Rootine claims to be a more comprehensive vitamin company

Besides the blood test and DNA analysis, Rootine also examines your lifestyle. It’s important to realize that some companies only base their decision on lifestyle examination and provide patients with a generic multivitamin solution. However, this alternative approach is not enough to choose a personalized multivitamin. 

The formula Rootine provides includes safe and customized doses of daily essential vitamins and minerals. Markedly, it covers 20 vital nutrients, carefully chosen based on your test results.


Dr. Daniel Wallerstorfer, Ph.D., is one of the drivers behind Rootine. He’s a biotechnologist, genetic scientist, and entrepreneur. He co-founded Rootine together with Rachel Sanders, a Harvard-educated entrepreneur in the health and wellness industry. Dr. Wallerstorfer is also the founder and CEO of Novogenia, a genetic lab.

Other members of the team at Rootine include Dr. Diaz, PharmD (Clinical Advisor), Dr. Harris MD (Clinical Advisor), Jordan Mazur Rd (Clinical Advisor / NFL), and Tye Jensen BS (Founding Team). 

Want a more comprehensive health test? Nebula Genomics offers Whole Genome Sequencing! Unlike Rootine, which only analyzes one aspect of your genes, Nebula Genomics uses 30X whole genome sequencing to allow you to explore 100% of your genome with regular research updates. Click here to learn more!

Rootine Science and a Rootine Report

Activities in Rootine are based on three major fields, namely nutrigenetic science, technology, and algorithm. Combining these three, Rootine examines genetics, blood, and lifestyle to choose suitable Rootine vitamins for individuals. In brief, the Rootine lab offers two at-home tests: a genetic testing DNA Test for nutrigenetic analysis (50+ gene variants) and a Blood Nutrient Test for metabolomics (80+ metabolites). 

The DNA test analyzes a phenomenon called Nutrigenetics. Over 50 common genetic variations can influence how your body absorbs, metabolizes, and excretes nutrients. As a result, these variants affect nutrient sensitivities and deficiencies.

Many people lack the vital nutrients their bodies need to function optimally. To understand what an individual needs, Rootine will look at the genetic factors that influence the absorption of nutrients. It also offers health insights into how your genes influence which nutrients you need. 

The blood test

The Blood Nutrient Test allows it to perform Metabolomics — a study of your body’s metabolism and nutrient function in blood levels. The report includes overall information on blood nutrient levels under the categories of micronutrients, amino acids, metabolism, detoxification, and science. Furthermore, each section provides the current status and action items. 

A sample report for normal levels of biotin.
An example of a blood test report for someone with normal levels of biotin.
A sample report for low iron
An example of a blood test report for someone who may need extra iron

Both of these tests allow Rootine to hyper-personalize the nutrient formula required by each customer. It then uses its technology to engineer a suitable multivitamin for the individual. 

To ensure proper absorption, innovative slow-release microbeads deliver customized dosages of vitamins into your bloodstream throughout the day. This slow-release strategy also helps to ensure that an accurate, Rootine customized dosage of vitamins is administered. 

Did you know you can test your metabolism at home? Learn more in our article about metabolism tests at home.

Rootine Review 

The Rootine formula contains safe and effective doses of 20 vital nutrients and minerals. As shown above, your test results determine the quantity of each nutrient and mineral in your supplement. Each of these custom vitamins and minerals has different roles to play. 

A sample of the Rootine formula
A sample of the 20 vital nutrients that make up the Rootine formula

The 20 essential nutrients and key vitamins in the Rootine formula include:

  • Vitamin B12 (methylcobalamin)
  • Vitamin B2 (Riboflavin)
  • Selenium (selenomethionine)
  • Folate (B9) (Methylfolate / folic acid)
  • Manganese (Manganese sulfate)
  • Vitamin C (Ascorbic acid)
  • Vitamin B6 (Pyroxidine hydrochloride)
  • Vitamin D3 (Cholecalciferol)
  • CoQ10 (ubiquinone)
  • Vitamin E (d-alpha-tocopheryl acetate)
  • ALA (alpha-lipoic acid)
  • MSM (Methylsulfonylmethane)
  • Magnesium (Magnesium hydroxide)
  • Zinc (Zinc bisglycinate)
  • Phytosterols (sito-, campe-, signma-)
  • Copper (copper sulfate)
  • Calcium (calcium carbonate)
  • Iron (iron bisglycinate)
  • Omega 3s

Ingredient details

These ingredients are essential for maintaining health and wellness. For example, vitamin B12 serves the function of regulating the level of homocysteine in the blood. Therefore, if you have a high homocysteine level in the body, your heart may be negatively affected. 

Calcium helps to keep the bone healthy and also aids in detoxification. In addition, alpha-lipoic acid (ALA) is a mitochondrial compound that supplies your cell with energy. It also helps control the body’s oxidation rate by increasing the number of antioxidant enzymes. 

The selenium contained in the Rootine formula is an essential part of some enzymes, some of which help neutralize free radicals. More so, some genotypes require more selenium to increase antioxidant protection.

Rootine provides an example of how genetic information is useful for determining supplement formulations on its website. 

For example, it provides is that of which 33% of the population has a genetic variation on one or both copies of their GPX-1 gene, which increases their selenium requirements. 

On the other hand, people with a variation on the HFE gene should avoid iron supplements, and those with a variation on the NQO1 gene would waste time and money taking coenzyme Q10, which would not be effective.

How To Take a Rootine Test

A Rootine test requires a few steps. 

First, Rootine requires you to answer an 18-question lifestyle quiz. Questions include:

“Do you smoke cigarettes?”

“Do you follow any specific diet?”

“How tall and heavy are you?”

The quiz shouldn’t take more than 10 minutes. After that, you’ll enter your contact information. If you have a DNA test result from 23andMe, AncestryDNA, or similar companies, you can upload it directly. Then, Rootine’s scientists will analyze it.

You can also seek the service of a Healthcare professional to help you upload your blood panel results. This will provide Rootine with more data to better personalize your basic multivitamin. 

However, there’s a more straightforward approach that you can adopt to submit your DNA and/or metabolites via Rootine’s kits. The DNA test involves swabbing your mouth very early in the morning as you wake.

For the metabolite test, you will complete a finger-prick to place a few drops of blood onto filter paper. You will also collect a urine sample. Finally, all samples can be sent back through postage-paid boxes. 

You will receive your first set of Rootine’s vitamins less than two months after you mail your DNA samples and/or other tests to the lab or upload your DNA test or blood panel to the website. 

Review of Rootine Cost

Rootine multivitamins packages include a DNA test as an add-on for an extra cost of $115. This then allows Rootine to analyze your genetic information and create a customized supplement plan based on the 18 essential nutrients and key vitamins that make up its formula.

On the other hand, customers can purchase just the blood DNA test for $125.

Rootine cost with multivitamin
Rootine cost with multivitamin

The Nutrigenetics DNA test covers 51 genetic variants. As shown above, if you already have DNA data from or 23andMe, you can upload it for free after purchase.

The offer includes a 90-days supply of the multivitamins at $2.33/day. Therefore, that amounts to $69.99 per month for three months.

Rootine Privacy Review

The company’s privacy policy explains how it collects, uses, maintains, and discloses all the information collected from users. Users must agree with the company’s privacy policy before they seek its service.

Rootine mentions that when users send samples, it extracts DNA information to provide the services, including personalized vitamins. The samples are destroyed, but the genetic information is kept in case a user wants to purchase any product in the future. Thus, this genetic data is removed only at client’s request.

Other Rootine Reviews

Reddit users attest to the authenticity of the service offered by Rootine. These Rootine vitamin reviews also mention that Rootine gives peace of mind in vitamin selection. 

In addition, customer reviews are available on the Rootine website. Here, customers ranked the products 5 stars.

Nebula Genomics

At Nebula Genomics, we offer 30x Whole-Genome Sequencing (WGS), which provides detailed information about your DNA. We also allow users to upload their DNA data from 23andMe and AncestryDNA without being charged. Thus, you can get a complete genome analysis for free. 

However, if you don’t already have your DNA data, you can purchase a DNA kit from us at a quite affordable price. With that, we’ll examine your DNA using the Whole-Genome Sequencing method. 

Unlike companies like Rootine, which only provide DNA results on a single health aspect meant to sell its supplement products, Nebula Genomics analyzes your entire genome to provide you with the most comprehensive view of your genetics. With our whole genome sequencing technology, you can learn not only about how nutrients are being absorbed, metabolized, and excreted in the body but also about countless other health predispositions. 

We know how confidential your data is. Thus, we adopt blockchain-based technology and privacy-preserving computing to ensure that your data are well secured when working on our page. Hence, you don’t have to worry about a third-party having access to your data without your consent. 

Also, our privacy techniques are transparent. We use blockchain-based technology and privacy-preserving computing to ensure your data security while using our page.

Should you purchase our kits, we’ll grant you access to Nebula Explore. This gives you further access to updates and personalized reports based on recent scientific discoveries. You’ll also be permitted to access our genome exploration tools plus deep ancestry (Y-CHR and mtDNA sequencing).

Rootine vs. Nebula Genomics

RootineNebula Genomics
Testing MethodDNA, blood, and lifestyle30X Whole Genome Sequencing
Reportinginformation about the nutrient you need in your body systemGenetic predisposition
Ancestry ReportingNoDeep ancestry reporting with full Y chromosome and mtDNA sequencing
Options to upload raw DNA dataYesYes
Focus on PrivacyYesYes (learn more)
Data Exploration ToolsNoNo (learn more)
Cost$115-$125 $0 – $299

Other companies

Persona Nutrition is a different kind of personalized supplement company that creates a personalized nutrition plan based on an online assessment. If you’re interested in gut health and customized weight loss programs and supplements, you may want to look at these other reviews:

Weight loss:

  • Athletic Greens (foundational nutrition powder)
  • Bio X4 (probiotic weight management supplement)
  • Contrave (prescription weight loss pills)
  • Goli Nutrition (apple cider vinegar gummies)
  • Hydroxycut (weight loss supplements)
  • Iaso Tea (a tea for cleaning and weight loss)
  • Ka’Chava (meal replacement shake)
  • Leptitox (supplement to increase leptin and induce quick weight loss)
  • Lipozene (fiber-based weight loss supplement)
  • Phentermine (prescription to help with short term weight control)
  • Resurge (deep sleep supplement for weight loss)

Gut health:

  • Atlas Biomed (microbiome and nutrition recommendations)
  • Biohm (gut health, including bacteria and fungi)
  • Biomesight (gut testing and recommendations)
  • DayTwo (gut health, personalized recommendations for blood glucose optimization)
  • Ixcela (blood test for gut health and personalized recommendations)
  • Kean Health (gut health, recommendations, plus a gene test with 100+ traits)
  • OlaWell (recommendations to avoid food intolerances)
  • Onegevity (gut health and personalized recommendations)
  • Sun Genomics (gut microbiome testing and personalized probiotics for adults, children, and infants)
  • Ombre (formally Thryve) (personalized probiotics)
  • Verisana (hormone, gut, and STD tests, plus many more)
  • Viome (gut health and microbiome testing)

You may also be interested in virtual health care such as that offered by Teladoc and Lemonaid Health!

Did you find our Rootine review helpful? You can read more reviews on our blog and check out our complete guide to the best DNA test kit and other home tests.

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