Toolbox Genomics review – What can your panel reveal about health?

Toolbox Genomics Review Summary

Toolbox Genomics offers a wide range of genetic tests that focus on various aspects of health and wellness. Learn more in our Toolbox Genomics review!

Fiyin Ebemidayo, B.S.

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Summary

Toolbox Genomics offers a wide range of genetic testing, although most of the health panels must be ordered by a physician. Individuals can purchase either the DNA or epigenetic test on their own, which have prices competitive with similar services.

4.3

This review is written with the intent to be as unbiased as possible. However, it represents the opinion of an individual reviewer and is therefore subjective. Furthermore, at Nebula Genomics we seek to educate the public about the benefits of Whole Genome Sequencing. Information about our Whole Genome Sequencing DNA test is therefore incorporated into the review.

December 28, 2021

7 Facts from our Toolbox Genomics Review

  1. Location: San Francisco, California
  2. Products: Health and wellness-focused DNA and epigenetics tests 
  3. Cost: Pricing for the health-focused tests are not available. DNA tests cost $199 while the epigenetics test costs $249 
  4. Reports: The reports arrive about 6 weeks after the DNA sample has been submitted
  5. How it works: The health-focused tests can only be ordered by a physician. You can place an order for the wellness-focused kits yourself. Once the test is ordered, the test kit is sent to you. The DNA test kit contains the swab with which you will take cheek cell samples. Once you take the sample, you send it back to the lab and wait for your results
  6. Raw Data Access: Toolbox Genomics provides access to raw data to your physician
  7. Alternative Products: Nebula 30X Whole Genome Sequencing decodes all the information on your genome. Nebula reads over six million positions on your genome to provide you with reliable results that can be used in consultation with a medical professional

Toolbox Genomics Introduction

Toolbox Genomics is a gene testing company based in California that offers at-home DNA and epigenetics test kits to patients who would like to learn more about their overall health and wellness. Toolbox Genomics was founded by Erika Gray, a pharmacist, and Elvina Hewitt, a nurse, who were passionate about helping healthcare practitioners understand the relationship between genetics and healthy living. Toolbox Genomics offers 17 different DNA tests, of which only 2 can be ordered directly by a consumer. 

CLIA/CAP certified labs are used to process samples and generate data. By working with practitioners and wellness professionals, the company is dedicated to incorporating genetic information into practices.

Did you know that by sequencing your whole genome, you can learn more about disease risk and general wellness? This may help determine if additional services may be right for you. Nebula Genomics offers affordable whole genome sequencing that decodes 100% of your genome. Click here to learn more!

Toolbox Genomics Review

Review of Toolbox Genomics products

DNA test

The DNA test is available for individuals to purchase themselves online. It decodes various genetic health predispositions and provides personalized exercise, diet, supplement and lifestyle guidance. It includes 300+ health reports from 1,000 analyzed genetic markers. This DNA test provides:

  • 16 health predisposition traits
  • Custom meal plans
  • Personalized training regime
  • Vitamin recommendations
Toolbox Genomics DNA and epigenetics tests
Toolbox Genomics DNA and epigenetics tests

Epigenetics test

This test is also available for individual purchase. It measures the expression of DNA that is controlled by lifestyle and environmental factors. By targeting these areas, customers are able to better improve their health and wellness. By learning how their lifestyle has affected their genes, customers can view 5 insights they can change:

  • Biological age
  • Eye age
  • Hearing age
  • Memory age
  • Inflammation score

This test can also help you track DNA changes over time.

Both the DNA test and the epigenetics test come with a simple saliva collection kit, in-app + downloadable results, and app updates. They also include a virus risk score, which examines 60 different genes that play a role in susceptibility to different viruses, including respiratory viruses.

Muhdo is another company that offers epigenetics.

Review of Toolbox Genomics Health panels

The following health panels available from Toolbox Genomics are only available through purchase by a licensed practitioner, who can provide medical advice on how the body responds to certain health conditions. 

Cardiometabolic Panel

The Toolbox Genomics Cardiometabolic Panel reveals information on a patient’s obesity, insulin resistance, sugar dysregulation, and other cardiometabolic conditions. This test helps to break down 8 traits and 78 genes, giving your physician insight into the risk factors of your condition. 

The report of this test is accompanied by research-backed recommendations based on the results of your health testing which will enable your physician to make informed treatment decisions for you. Your physician gets detailed information on what nutrients are best for your heart and metabolism as well as lifestyle behaviors you can adopt in order to live a healthier life. 

Cognitive Panel

This test is developed to assist people with psychological disorders such as depression, anxiety, loss of memory, and trauma. It helps your doctor understand your condition better to make him more proactive in recommending diet changes, exercises and treatments to improve your condition. The cognitive panel tests for 10 traits and 104 genes associated with different cognitive disabilities. 

Energy/Fatigue Panel

This test will help your physician pinpoint the cause of your fatigue, headaches, and body pains. Making use of genetic testing, it analyzes 10 traits and 61 genes tied with energy and fatigue levels, allowing customized treatment plans to be created for you. 

Details of Toolbox Genomics Energy/Fatigue panel
Review of Toolbox Genomics Energy/Fatigue panel

GI Panel

This test gives your physician better insight into your gastrointestinal problems such as diarrhea and constipation. The results are based on the analysis of 5 traits and 56 genes linked with gastrointestinal health. The results help your doctor make a decision on the best foods and lifestyle choices for your body.

Immune Panel

This panel is designed to help people with auto-immune conditions and other conditions that can lead to hormonal dysfunction. The panel analyzes 5 traits and 99 genes to help generate a tailored report and customized health recommendations for you. 

The following tests are available to both licensed practitioners and wellness professionals:

Respiratory Resilience

The results of this test are meant to provide useful insight that will help you make the right choices for your respiratory system. This will help boost the resilience of your respiratory organs and decrease your risk of being infected by viruses in your surroundings. The test analyses 11 traits and 55 genes.

Nutrition Optimization

This test gives you insight into things like your alcohol and caffeine metabolism, food intolerances, and nutrient deficiencies. The Nourish panel is specifically designed to help you make the best diet and nutrition choices for your body based on your test results. It tests 20 traits and 39 genes in order to help you eat right and feel your best at all times.

Details of ToolBox Genomics Nutrition Optimization panel
Review of ToolBox Genomics Nutrition Optimization panel

Detox Panel

Designed to help people with weight loss problems, skin issues, mood swings and those who just want to get rid of environmental toxins, this test analyzes 17 different traits and 28 genes. 

It provides an answer for why you find it difficult to lose weight and other conditions that may be caused by toxins and provides tailored diet and lifestyle recommendations to help you get rid of toxins and to stay healthy in a toxic environment. 

Endurance

This test is best for endurance performance athletes and can help provide the extra bit of advantage which you need against your opponents. With specialized diet plans and lifestyle choices, you are able to eke out every drop of performance from your body. This panel tests for 24 traits and 40 genes. This includes recovery and oxidative stress.

Health Enrichment

This test provides an analysis of 21 traits and 35 genes, helping your physician make recommendations on how you can live a healthier life. This is a great test for those who are new to genetic testing as it provides a little bit of everything.

Hormone Panel

This test makes use of an analysis of 7 traits and 22 genes to shed light on the causes and treatment of hormone-related conditions such as depression, loss of libido, and irregular menstrual cycles.

Weight Management

This panel provides insight into how your body processes different foods in order to make an informed decision on the best foods to eat to attain a specific weight goal. The test also detects your risk of obesity and eating behaviors using the results from the analysis of 16 traits and 22 genes. 

Additional Key Opinion Leader (KOL) Panels were specifically curated by Functional Medicine KOLs known for their renown work in their area of interest and notoriety.

Gut/Brain panel

Gut conditions can lead to brain problems, and this test has been designed to help practitioners to understand the genetic aspect of the gut to brain relationship. This panel analyses 6 conditions and 28 genes in order to give an accurate recommendation to your doctor.

Musculoskeletal Panel

This test is great for athletes, people with bad posture, and people who like to keep fit. It will help your physician choose the best diet and lifestyle decisions you will have to make in order to do more exercise.

Details of Toolbox Genomics Musculoskeletal panel
Review of Toolbox Genomics Musculoskeletal panel

Concussion Panel

This test is designed for people who play contact sports and have noticed a decline in their cognitive abilities and those who just want to check on their brains. The test checks for 5 conditions and 27 genes.

Taking a Toolbox Genomics Test

The Toolbox Genomics tests are only available to clients in the United States. A majority of the panels cannot be ordered directly by the client but only through a physician or practitioner. However, individuals can order the commercial DNA test or epigenetics test.

Once the test kit is ordered, the customer swabs the inside of the cheek using the included swab about a dozen times, breaks the swab into the included vial and then sends it back to Toolbox Genomics.

Taking a Toolbox Genomics test
Taking a Toolbox Genomics test

Results are available through the customizable Toolbox Genomics app. After receiving the sample in the lab, results for the DNA test are received in 4 weeks while the epigenetic results are available in 6-8 weeks.

Review of Toolbox Genomics Cost

The prices for most of the Toolbox Genomic tests are not available on the website as they must be purchased through a doctor’s office. The DNA test is $199 while the epigenetics test is $249. If you buy the tests together, they cost $299, a savings of $50. 

Currently, the tests are not covered by insurance companies.

Review of Toolbox Genomics Reports

Your Toolbox Genomic report arrives about four to six weeks after you send in your sample, depending on whether you ordered the DNA or epigenetic tests. These consumer reports are available either as a multipage PDF file in your email or through the customizable app. 

The DNA results are located under the results tab at the bottom of the app. Customers can then scroll through the various genetic predispositions tested for and receive their personalized results.

DNA results on metabolic rate
DNA results on metabolic rate

You are able to speak to an agent if you would like to have any part of the report explained further. 

If purchased, the epigenetics portion of the app will provide the customer’s overall biological age and a breakdown of what goes into that score.

Epigenetics results on overall biological age
Epigenetics results on overall biological age

Sample reports of the health panels available to licensed practitioners and wellness professionals are available on the company’s website. These samples include PDF versions of the 20-30 page health action plans and a practitioner detailed appendix. These reports can help potential customers decide if talking to their doctor about any of these panels is right for them.

Each report is divided into three sections: trait impact, traits, and recommendations. Most of the report is easy to understand and interpret. An expanded appendix provides more detailed results for healthcare professionals. 

Portions of the Toolbox Genomics health panel reports
Portions of the Toolbox Genomics health panel reports

Impact traits are specific to the individual tested. They provide a high-level snapshot of the clinical significance of each trait within the panel.

Sample report of Respiratory Resilience impact traits
Sample report of Respiratory Resilience impact traits

A large portion of the report is based on recommendations made on genetically influenced traits. These recommendations can include supplements (vitamins and minerals), diet, lifestyle, exercise, and further testing.

The appendix section of the report provides detailed information for health professionals. This includes the specific genes and SNPs detected in the test to prompt the specific recommendations.  

Review of Toolbox Genomics Privacy

Toolbox Genomics claims to store your personal information or DNA without any of your personal details. Your sample is also destroyed once sequencing is complete and you can request that your raw genetic data be destroyed at any point in time.

Pros and Cons

Pros

  • Detailed reports on specific health areas
  • Personalized recommendations based on the results

Cons

  • It takes a long time to get the results of your test (4-8 weeks)
  • Most of the test kits can only be ordered through a practitioner

Nebula Genomics

Nebula Genomics provides a comprehensive view of your genome made possible through the use of 30x Whole Genome Sequencing. This technique enables Nebula to analyze the full genetic sequence of your DNA which is about 6.4 billion base pairs. This is a massive difference from other genetic tests which only analyze about 0.02% of your DNA or focus on specific SNPs, such as Toolbox Genomics. 

The Nebula Genomics test kits can be ordered from your home. Although these tests are not diagnostic, they are of the highest quality and can be taken to your physician for analysis. They focus on predispositions to hundreds of traits and health conditions. Plus, you receive raw data of your entire genome. Thus, as more research becomes available you can continue to return to your data and discover more about your DNA. Nebula helps with this through DNA exploration tools and weekly updated reports based on the latest scientific discoveries. 

The results of your genomic testing are completely private and you have total control over how your data is managed. Three test kits are available for purchase. The basic kit costs $99, the deep kit costs $299, and the ultra-deep kit costs $999. All of the Nebula Genomics test kits also provide you with ancestry reports in addition to the health reports you get. 

Toolbox GenomicsNebula Genomics
Sample collectionCheek swabSaliva
DNA testing methodN/AWhole Genome Sequencing (30x coverage)
Ancestry testingNoDeep ancestry reporting with full Y chromosome and mtDNA sequencing
Raw DNA downloadNoYes (FASTQ, BAM, and VCF files)
ReportA single report provided at the end of testingWeekly genetic reports based on the latest research and data (learn more)
Toolbox Genomics vs Nebula Genomics

Did you like our Toolbox Genomics review? You can read more reviews on our blog and check out our complete guide to the best DNA test kit and other home tests.

This company offers a variety of tests for different inquiries. Other companies that offer different testing options include:

  • 24Genetics (various tests for health, ancestry, sports, skin, pharmacogenomics, WES, and WGS)
  • Dynamic DNA Labs (at home tests for health, ancestry, skin, personality, and more)
  • Genebase (genetic tests for lifestyle, health, disease, traits, behavior, and ancestry)
  • GenebyGene (diagnostics, ancestry, and special services for forensics and researchers)
  • GenePlanet (European testing company for lifestyle, ancestry, and health)
  • Genovate (relationship, health, fitness, and ancestry tests)
  • HealthCodes DNA (personalized plans for wellness, nutrition, and fitness)
  • Mapmygenome (preventative genetics, diagnostics, and Indian ancestry)
  • MiaDNA (health, wellness, traits, and fitness for adults and children)
  • myDNA (personalized fitness, diet, and medication plans)
  • PerkinElmer Genomics (WES, WGS, newborn screening, and more)